TRO (gen)

Trofinin je protein kojim je kod ljudi kodiran genom TRO.

TRO (gen)
Identifikatori
Aliasi	TRO
Vanjski ID-jevi	OMIM: 300132 MGI: 1928994 HomoloGene: 75113 GeneCards: TRO
Lokacija gena (čovjek) Hrom. Hromosom X Bend Xp11.21 Početak 54,920,462 bp Kraj 54,931,431 bp
Lokacija gena (miš) Hrom. Hromosom X (miš) Bend X|X F3 Početak 149,428,300 bp Kraj 149,440,579 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine Ćelijska komponenta • ćelijska membrana • integral component of plasma membrane • intrinsic component of plasma membrane Biološki proces • Ćelijska adhezija • embryo implantation • homophilic cell adhesion via plasma membrane adhesion molecules Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	7216	56191
Ensembl	ENSG00000067445	ENSMUSG00000025272
UniProt	Q12816 Q9BX88	n/a
RefSeq (mRNK)	NM_001039705 NM_001271183 NM_001271184 NM_016157 NM_177556 NM_177557	NM_001002272 NM_001290770 NM_001290771 NM_001290772 NM_019548 NM_207679
RefSeq (bjelančevina)	NP_001034794 NP_001258112 NP_001258113 NP_057241 NP_808224 NP_808225 NP_808225.1	n/a
Lokacija (UCSC)	Chr X: 54.92 – 54.93 Mb	Chr X: 149.43 – 149.44 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Ovaj gen kodira membranski protein koji posreduje apikalnu adheziju ćelija između trofoblastnih ćelija i lumenskih epitel nih ćelija endometrija i upleten je u početno vezanje tokom proces implantacije embriona. Povezan je sa porodicom gena MAGED sa sličnošću sekvenci i lokacijom hromosoma. Za njega je pronađeno je više varijanti alternativno prerađenih transkripta; međutim, priroda nekih varijanti u punoj dužini nije definirana.

Dopunska litratura

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• Fukuda MN, Sato T, Nakayama J, et al. (1995). "Trophinin and tastin, a novel cell adhesion molecule complex with potential involvement in embryo implantation". Genes Dev. 9 (10): 1199–210. doi:10.1101/gad.9.10.1199. PMID 7758945.
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• Suzuki N, Zara J, Sato T, et al. (1998). "A cytoplasmic protein, bystin, interacts with trophinin, tastin, and cytokeratin and may be involved in trophinin-mediated cell adhesion between trophoblast and endometrial epithelial cells". Proc. Natl. Acad. Sci. U.S.A. 95 (9): 5027–32. doi:10.1073/pnas.95.9.5027. PMC 20207. PMID 9560222.
• Suzuki N, Nakayama J, Shih IM, et al. (1999). "Expression of trophinin, tastin, and bystin by trophoblast and endometrial cells in human placenta". Biol. Reprod. 60 (3): 621–7. doi:10.1095/biolreprod60.3.621. PMID 10026108.
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• Wang HY, Xing FQ, Chen SL (2002). "Expression of trophinin in the cycling endometrium and its association with infertility". Di Yi Jun Yi Da Xue Xue Bao. 22 (6): 539–41. PMID 12297480.
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• Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res. 288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID 12878157.
• Nakayama J, Aoki D, Suga T, et al. (2004). "Implantation-dependent expression of trophinin by maternal fallopian tube epithelia during tubal pregnancies: possible role of human chorionic gonadotrophin on ectopic pregnancy". Am. J. Pathol. 163 (6): 2211–9. doi:10.1016/S0002-9440(10)63579-1. PMC 1892375. PMID 14633596.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bertrand M, Huijbers I, Chomez P, De Backer O (2005). "Comparative expression analysis of the MAGED genes during embryogenesis and brain development". Dev. Dyn. 230 (2): 325–34. doi:10.1002/dvdy.20026. PMID 15162511.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Aoyama J, Nakayama Y, Sugiyama D, et al. (2006). "Apical cell adhesion molecule, trophinin, localizes to the nuclear envelope". FEBS Lett. 579 (28): 6326–32. doi:10.1016/j.febslet.2005.10.012. PMID 16288751.