Izvorni kôd stranice Koenzim B

{{Infokutija hemijski spoj
| Strukturna formula   =  [[Datoteka: Coenzyme B (CoB).svg|200px]] 
| Hemijski spoj        =  Koenzim B
| Druga imena          = [[IUPAC]]-ime: 2-[(7-merkapto-1-oksoheptil)amino]-3-fosfonooksibutanska kiselina
|OtherNames=
| Sumarna formula      =C<sub>11</sub>H<sub>22</sub>NO<sub>7</sub>PS
| CAS registarski broj = 104302-77-4
| SMILES               = O=C(N[C@@H](C(=O)O)[C@H](OP(=O)(O)O)C)CCCCCCS
| InChI                = 1/C11H22NO7PS/c1-8(19-20(16,17)18)10(11(14)15)12-9(13)6-4-2-3-5-7-21/h8,10,21H,2-7H2,1H3,(H,12,13)(H,14,15)(H2,16,17,18)/t8-,10-/m1/s1
| Kratki opis          =
| Molarna masa         = 
| Agregatno stanje     = 
| Gustoća              = 
| Tačka topljenja      = 
| Tačka ključanja      = 
| Pritisak pare        = 
| Rastvorljivost       = 
| Viscosity = 
| Dipolni moment       = 
| NFPA 704             = {{NFPA 704 |H = 0 |F = 0| R = 0}}
}}

'''Koenzim B'''  − 7-merkaptoheptanoiltreoninfosfat − je neophodan  u  [[redoks]] reakijama [[metabolizam|metabolizma]] [[metanotrof]]a.<ref>{{cite journal |author=Noll KM, Rinehart KL, Tanner RS, Wolfe RS |title=Structure of component B (7-mercaptoheptanoylthreonine phosphate) of the methylcoenzyme M methylreductase system of Methanobacterium thermoautotrophicum |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue=12 |pages=4238–42 |year=1986 |pmid=3086878 |doi=10.1073/pnas.83.12.4238 |pmc=323707}}</ref> Njegova  molekula sadrži [[tiol]], koji je glavno mjesto reakcije.

Ovaj koenzim reagira  sa 2-metiltioetansulfonatom (metil-[[koenzim M|koenzimom M]], skraćeno {{chem|CH|3|–S–CoM}}), pri čemu se u procesu  [[metanogeneza|metanogeneze]]formira [[metan]]:<ref>{{cite journal |author=Thauer RK |title=Biochemistry of methanogenesis: a tribute to Marjory Stephenson. 1998 Marjory Stephenson Prize Lecture |journal=Microbiology |volume=144 |issue=Pt 9 |pages=2377–406 |year=1998 |month=September |pmid=9782487 |url=http://mic.sgmjournals.org/cgi/pmidlookup?view=long&pmid=9782487 |doi=10.1099/00221287-144-9-2377 |access-date=12. 5. 2016 |archive-date=17. 5. 2020 |archive-url=https://web.archive.org/web/20200517185916/http://http%3a//mic.sgmjournals.org/cgi/pmidlookup%3Fview%3Dlong%26pmid%3D9782487/ |url-status=dead }}</ref>

; {{chem|link=Koenzim M|CH|3|–S–CoM}} + HS–CoB → {{chem|CH|4}} + CoB–S–S–CoM 
Ovu konverziju katalizira [[enzim]] [[Koenzime-B sulfoetiltiotransferaza|metil koenzim M reduktaza]], koja sadrži [[kofaktor F430]] kao [[prostetska grupa|prostetsku grupu]].

Srodna pretvorba  koja koristi HS-CoB i HS-CoM počiva na redukciji [[fumarna kiselina|fumarata]] do [[sukcinska kiselina|sukcinata]], koja je [[Kataliza|katalizirana]] [[fumarat reduktaza|fumarat reduktazom]]:<ref>{{cite journal |author=Heim S, Künkel A, Thauer RK, Hedderich R |title=Thiol:fumarate reductase (Tfr) from Methanobacterium thermoautotrophicum—identification of the catalytic sites for fumarate reduction and thiol oxidation |journal=Eur. J. Biochem. |volume=253 |issue=1 |pages=292–9 |year=1998 |month=April |pmid=9578488 |url=http://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0014-2956&date=1998&volume=253&issue=1&spage=292 |doi=10.1046/j.1432-1327.1998.2530292.x}}</ref>
; {{chem|CH|3|–S–CoM}} + HS–CoB <sup>–</sup>{{chem|O|2|CCH&#61;CHCO|2|-}} → <sup>–</sup>{{chem|O|2|CCH|2|–CH|2|CO|2|-}} + CoB–S–S–CoM

==Također pogledajte==
*[[Koenzim]]

== Reference ==
{{reflist|2}}

== Vanjski linkovi ==
{{Portal|Hemija}}

{{Commons|Coenzyme B}}

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