Izvorni kôd stranice RAR-alfa

{{Infokutija gen}}
'''Receptor alfa retinojske kiseline''' ('''RAR-α'''), znan i kao '''NR1B1''' (član 1 grupe B potporodice 1 jedarnih receptora) jest [[jedarni receptor]]ski [[protein]] koji je kod [[ljudi]] [[kodon|kodiran]] [[gen]]om '''RARA'''   sa [[hromosom 17|hromosoma 17]].<ref name="pmid2825036">{{cite journal | vauthors = Giguere V, Ong ES, Segui P, Evans RM | title = Identification of a receptor for the morphogen retinoic acid | journal = Nature | volume = 330 | issue = 6149 | pages = 624–9 | year = 1987 | pmid = 2825036 | doi = 10.1038/330624a0 | s2cid = 4308015 | bibcode = 1987Natur.330..624G }}</ref><ref name="pmid8244378">{{cite journal | vauthors = Anderson LA, Friedman L, Osborne-Lawrence S, Lynch E, Weissenbach J, Bowcock A, King MC | title = High-density genetic map of the BRCA1 region of chromosome 17q12-q21 | journal = Genomics | volume = 17 | issue = 3 | pages = 618–23 | date = septembar 1993 | pmid = 8244378 | doi = 10.1006/geno.1993.1381 }}</ref>

NR1B1 je gen sa proteinskim proizvodom i ima hromosomsku lokaciju 17q21.2. RARA kodira receptora jedarnog [[hormon]]a, receptor retinojske kiseline, podtip alfa i sam je [[transkripcijski faktor]]. Postoje još dva podtipa RAR-a, beta i gama.<ref>{{Cite web|title=Gene symbol report {{!}} HUGO Gene Nomenclature Committee|url=https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9864|access-date=27. 4. 2021|website=www.genenames.org}}</ref><ref name=":0">{{Cite web|title=OMIM Entry - * 180240 - RETINOIC ACID RECEPTOR, ALPHA; RARA|url=https://www.omim.org/entry/180240|access-date=27. 4. 2021|website=www.omim.org}}</ref>

==Aminokiselinska sekvenca==

Dužina [[polipeptid]]nog lanca je  462 [[aminokiseline]], a [[molekularna masa|molekulska težina]]
50.771 [[dalton (jedinica)|Da]].
{{legenda aminokiselina}}
<table  style="font-family:monospace;">
<tr style="text-align:right;"><th>10</th><th></th><th>20</th><th></th><th>30</th><th></th><th>40</th><th></th><th>50</th></tr>
<tr style="background-color: #eee;"><td>MASNSSSCPT</td><td style="background-color: #f9f9f9;"></td><td>PGGGHLNGYP</td><td style="background-color: #f9f9f9;"></td><td>VPPYAFFFPP</td><td style="background-color: #f9f9f9;"></td><td>MLGGLSPPGA</td><td style="background-color: #f9f9f9;"></td><td>LTTLQHQLPV</td></tr>
<tr style="background-color: #eee;"><td>SGYSTPSPAT</td><td style="background-color: #f9f9f9;"></td><td>IETQSSSSEE</td><td style="background-color: #f9f9f9;"></td><td>IVPSPPSPPP</td><td style="background-color: #f9f9f9;"></td><td>LPRIYKPCFV</td><td style="background-color: #f9f9f9;"></td><td>CQDKSSGYHY</td></tr>
<tr style="background-color: #eee;"><td>GVSACEGCKG</td><td style="background-color: #f9f9f9;"></td><td>FFRRSIQKNM</td><td style="background-color: #f9f9f9;"></td><td>VYTCHRDKNC</td><td style="background-color: #f9f9f9;"></td><td>IINKVTRNRC</td><td style="background-color: #f9f9f9;"></td><td>QYCRLQKCFE</td></tr>
<tr style="background-color: #eee;"><td>VGMSKESVRN</td><td style="background-color: #f9f9f9;"></td><td>DRNKKKKEVP</td><td style="background-color: #f9f9f9;"></td><td>KPECSESYTL</td><td style="background-color: #f9f9f9;"></td><td>TPEVGELIEK</td><td style="background-color: #f9f9f9;"></td><td>VRKAHQETFP</td></tr>
<tr style="background-color: #eee;"><td>ALCQLGKYTT</td><td style="background-color: #f9f9f9;"></td><td>NNSSEQRVSL</td><td style="background-color: #f9f9f9;"></td><td>DIDLWDKFSE</td><td style="background-color: #f9f9f9;"></td><td>LSTKCIIKTV</td><td style="background-color: #f9f9f9;"></td><td>EFAKQLPGFT</td></tr>
<tr style="background-color: #eee;"><td>TLTIADQITL</td><td style="background-color: #f9f9f9;"></td><td>LKAACLDILI</td><td style="background-color: #f9f9f9;"></td><td>LRICTRYTPE</td><td style="background-color: #f9f9f9;"></td><td>QDTMTFSDGL</td><td style="background-color: #f9f9f9;"></td><td>TLNRTQMHNA</td></tr>
<tr style="background-color: #eee;"><td>GFGPLTDLVF</td><td style="background-color: #f9f9f9;"></td><td>AFANQLLPLE</td><td style="background-color: #f9f9f9;"></td><td>MDDAETGLLS</td><td style="background-color: #f9f9f9;"></td><td>AICLICGDRQ</td><td style="background-color: #f9f9f9;"></td><td>DLEQPDRVDM</td></tr>
<tr style="background-color: #eee;"><td>LQEPLLEALK</td><td style="background-color: #f9f9f9;"></td><td>VYVRKRRPSR</td><td style="background-color: #f9f9f9;"></td><td>PHMFPKMLMK</td><td style="background-color: #f9f9f9;"></td><td>ITDLRSISAK</td><td style="background-color: #f9f9f9;"></td><td>GAERVITLKM</td></tr>
<tr style="background-color: #eee;"><td>EIPGSMPPLI</td><td style="background-color: #f9f9f9;"></td><td>QEMLENSEGL</td><td style="background-color: #f9f9f9;"></td><td>DTLSGQPGGG</td><td style="background-color: #f9f9f9;"></td><td>GRDGGGLAPP</td><td style="background-color: #f9f9f9;"></td><td>PGSCSPSLSP</td></tr>
<tr style="background-color: #eee;"><td>SSNRSSPATH</td><td style="background-color: #f9f9f9;"></td><td>SP</td></tr>
</table>

== Funkcija ==

[[Retinoid]]nu signalizaciju transduciraju članovi dvije porodice jedarnih receptora, receptor retinojske kiseline ([[RAR]]) i retinoidnui X-receptor ([[RXR]]), koji formiraju RXR/RAR heterodimere. U nedostatku [[ligand]]a, [[DNK]] vezani [[RXR]]/RARA potiskuje transkripciju, regrutacijom korepresora [[NCOR1]], SMRT ([[NCOR2]]), i [[histon-deacetilaza|histon-deacetilaze]]. Kada se ligand veže za kompleks, inducira konformacijsku promjenu koja omogućava regrutovanje koaktivatora, histon-acetiltransferaza i osnovnog transkripcijskog mehanizma.<ref name="entrez">{{cite web | title = Entrez Gene: retinoic acid receptor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5914}}</ref>

Receptor retinoične kiseline alfa, protein, stupa u interakciju sa [[retinojska kiselina|retinojskom kiselinom]], derivatom [[vitamin A|vitamina A]], koji ima važnu ulogu u [[ćelijski rast|rastu ćelija]], [[ćelijska diferencijacija|diferencijaciji]] i formiranju [[organ]]a u razvoju embriona.<ref name=":0" /><ref name=":1">{{cite journal | vauthors = Kam RK, Deng Y, Chen Y, Zhao H | title = Retinoic acid synthesis and functions in early embryonic development | journal = Cell & Bioscience | volume = 2 | issue = 1 | pages = 11 | date = mart 2012 | pmid = 22439772 | pmc = 3325842 | doi = 10.1186/2045-3701-2-11 }}</ref>

Kada se retinoična kiselina veže za RAR, oni pokreću [[Transkripcija (biologija)|transkripciju]] i omogućavaju ekspresiju njihovog gena.<ref name=":1" />

== Klinički značaj ==

RA signalizacija je u [[korelacija]]ma sa nekoliko signalnih puteva u ranom [[embriogeneza|embrionskom razvoju]]. Prvo, učestvuje u formiranju [[embrion ska osovina|embrionske osovine]], koja uspostavlja simetriju u potomstvu. RA također utiče na nervnu diferencijaciju. regulacijom ekspresije proneurvnog indukcionog faktora meurogenina 2 ([[Neurogenin-2|neurog2]]). RA utiče na kardiogenezu, jer ima posebnu ulogu u formiranju [[srčana pretkomora|srčane pretkomore]]. RA također ima ulogu u razvoju [[pankreas]]a, [[bubreg]]a, [[pluća]] i ekstremiteta.<ref name=":1"/>

[[translokacija (genetika)|Translokacije]] koje uvijek uključuju preuređivanje gena RARA su kardinalna karakteristika [[APL|akutne promijelocitne leukemije]] (APL; MIM 612376). Najčešća translokacija je t(15,17)(q21;q22), koja spaja gen RARA sa genom [[PML]].<ref name="pmid17468032">{{cite journal | vauthors = Vitoux D, Nasr R, de The H | title = Acute promyelocytic leukemia: new issues on pathogenesis and treatment response | journal = The International Journal of Biochemistry & Cell Biology | volume = 39 | issue = 6 | pages = 1063–70 | year = 2007 | pmid = 17468032 | doi = 10.1016/j.biocel.2007.01.028 }}</ref>

== Interakcije ==

Pokazalo se da receptor alfa retinojske kiseline [[interakcija protein-protein|reaguje]] sa:
{{div col|colwidth=15em}}
* [[BAG1]],<ref name="pmid9642262">{{cite journal | vauthors = Liu R, Takayama S, Zheng Y, Froesch B, Chen GQ, Zhang X, Reed JC, Zhang XK | display-authors = 6 | title = Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells | journal = The Journal of Biological Chemistry | volume = 273 | issue = 27 | pages = 16985–92 | date = juli 1998 | pmid = 9642262 | doi = 10.1074/jbc.273.27.16985 | doi-access = free }}</ref> 
* [[CLOCK]],<ref name="pmid11439184">{{cite journal | vauthors = McNamara P, Seo SB, Rudic RD, Sehgal A, Chakravarti D, FitzGerald GA | title = Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock | journal = Cell | volume = 105 | issue = 7 | pages = 877–89 | date = juni 2001 | pmid = 11439184 | doi = 10.1016/S0092-8674(01)00401-9 | s2cid = 6251321 | doi-access = free }}</ref>
* [[CCND3]],<ref name="pmid12482873">{{cite journal | vauthors = Despouy G, Bastie JN, Deshaies S, Balitrand N, Mazharian A, Rochette-Egly C, Chomienne C, Delva L | display-authors = 6 | title = Cyclin D3 is a cofactor of retinoic acid receptors, modulating their activity in the presence of cellular retinoic acid-binding protein II | journal = The Journal of Biological Chemistry | volume = 278 | issue = 8 | pages = 6355–62 | date = februar 2003 | pmid = 12482873 | doi = 10.1074/jbc.M210697200 | doi-access = free }}</ref>
* [[NCOA6]],<ref name="pmid11158331">{{cite journal | vauthors = Lee SK, Jung SY, Kim YS, Na SY, Lee YC, Lee JW | title = Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2 | journal = Molecular Endocrinology | volume = 15 | issue = 2 | pages = 241–54 | date = februar 2001 | pmid = 11158331 | doi = 10.1210/me.15.2.241 | doi-access = free }}</ref><ref name="pmid10567404">{{cite journal | vauthors = Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW | display-authors = 6 | title = A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo | journal = The Journal of Biological Chemistry | volume = 274 | issue = 48 | pages = 34283–93 | date = novembar 1999 | pmid = 10567404 | doi = 10.1074/jbc.274.48.34283 | doi-access = free }}</ref><ref name="pmid10823961">{{cite journal | vauthors = Ko L, Cardona GR, Chin WW | title = Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 11 | pages = 6212–7 | date = maj 2000 | pmid = 10823961 | pmc = 18584 | doi = 10.1073/pnas.97.11.6212 | bibcode = 2000PNAS...97.6212K | doi-access = free }}</ref> 
* [[NCOR1]],<ref name="pmid10336495">{{cite journal | vauthors = Dowell P, Ishmael JE, Avram D, Peterson VJ, Nevrivy DJ, Leid M | title = Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein | journal = The Journal of Biological Chemistry | volume = 274 | issue = 22 | pages = 15901–7 | date = maj 1999 | pmid = 10336495 | doi = 10.1074/jbc.274.22.15901 | doi-access = free }}</ref><ref name="pmid9531570">{{cite journal | vauthors = Guidez F, Ivins S, Zhu J, Söderström M, Waxman S, Zelent A | title = Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia | journal = Blood | volume = 91 | issue = 8 | pages = 2634–42 | date = april 1998 | pmid = 9531570 | doi = 10.1182/blood.V91.8.2634.2634_2634_2642 | doi-access = free }}</ref>
* [[NCOR2]],<ref name="pmid11929748">{{cite journal | vauthors = Dong S, Tweardy DJ | title = Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways | journal = Blood | volume = 99 | issue = 8 | pages = 2637–46 | date = april 2002 | pmid = 11929748 | doi = 10.1182/blood.V99.8.2637 }}</ref><ref name="pmid9256429">{{cite journal | vauthors = Hong SH, David G, Wong CW, Dejean A, Privalsky ML | title = SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 17 | pages = 9028–33 | date = august 1997 | pmid = 9256429 | pmc = 23013 | doi = 10.1073/pnas.94.17.9028 | bibcode = 1997PNAS...94.9028H | doi-access = free }}</ref>
* [[NPAS2]],<ref name=pmid11439184/>
* [[NRIP1]],<ref name="pmid14581481">{{cite journal | vauthors = Hu X, Chen Y, Farooqui M, Thomas MC, Chiang CM, Wei LN | title = Suppressive effect of receptor-interacting protein 140 on coregulator binding to retinoic acid receptor complexes, histone-modifying enzyme activity, and gene activation | journal = The Journal of Biological Chemistry | volume = 279 | issue = 1 | pages = 319–25 | date = januar 2004 | pmid = 14581481 | doi = 10.1074/jbc.M307621200 | doi-access = free }}</ref><ref name="pmid12549917">{{cite journal | vauthors = Farooqui M, Franco PJ, Thompson J, Kagechika H, Chandraratna RA, Banaszak L, Wei LN | title = Effects of retinoid ligands on RIP140: molecular interaction with retinoid receptors and biological activity | journal = Biochemistry | volume = 42 | issue = 4 | pages = 971–9 | date = februar 2003 | pmid = 12549917 | doi = 10.1021/bi020497k }}</ref><ref name="pmid8887632">{{cite journal | vauthors = L'Horset F, Dauvois S, Heery DM, Cavaillès V, Parker MG | title = RIP-140 interacts with multiple nuclear receptors by means of two distinct sites | journal = Molecular and Cellular Biology | volume = 16 | issue = 11 | pages = 6029–36 | date = novembar 1996 | pmid = 8887632 | pmc = 231605 | doi = 10.1128/MCB.16.11.6029 }}</ref>
* [[NR0B2]],<ref name="pmid8650544">{{cite journal | vauthors = Seol W, Choi HS, Moore DD | title = An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors | journal = Science | volume = 272 | issue = 5266 | pages = 1336–9 | date = maj 1996 | pmid = 8650544 | doi = 10.1126/science.272.5266.1336 | s2cid = 32853062 | bibcode = 1996Sci...272.1336S }}</ref><ref name="pmid9773978">{{cite journal | vauthors = Seol W, Hanstein B, Brown M, Moore DD | title = Inhibition of estrogen receptor action by the orphan receptor SHP (short heterodimer partner) | journal = Molecular Endocrinology | volume = 12 | issue = 10 | pages = 1551–7 | date = oktobar 1998 | pmid = 9773978 | doi = 10.1210/me.12.10.1551 | doi-access = free }}</ref>
* [[NR4A2]],<ref name="pmid7705655">{{cite journal | vauthors = Perlmann T, Jansson L | title = A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1 | journal = Genes & Development | volume = 9 | issue = 7 | pages = 769–82 | date = april 1995 | pmid = 7705655 | doi = 10.1101/gad.9.7.769 | doi-access = free }}</ref>
* [[PML]]<ref name="pmid10610177">{{cite journal | vauthors = Zhong S, Delva L, Rachez C, Cenciarelli C, Gandini D, Zhang H, Kalantry S, Freedman LP, Pandolfi PP | display-authors = 6 | title = A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins | journal = Nature Genetics | volume = 23 | issue = 3 | pages = 287–95 | date = novembar 1999 | pmid = 10610177 | doi = 10.1038/15463 | s2cid = 23613492 }}</ref> 
* [[RXRA]].<ref name="pmid12052862">{{cite journal | vauthors = Benkoussa M, Brand C, Delmotte MH, Formstecher P, Lefebvre P | title = Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter | journal = Molecular and Cellular Biology | volume = 22 | issue = 13 | pages = 4522–34 | date = juli 2002 | pmid = 12052862 | pmc = 133906 | doi = 10.1128/MCB.22.13.4522-4534.2002 }}</ref><ref name="pmid1314167">{{cite journal | vauthors = Bugge TH, Pohl J, Lonnoy O, Stunnenberg HG | title = RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors | journal = The EMBO Journal | volume = 11 | issue = 4 | pages = 1409–18 | date = april 1992 | pmid = 1314167 | pmc = 556590 | doi = 10.1002/j.1460-2075.1992.tb05186.x }}</ref>
* [[Src (gen)|Src]],<ref name="pmid10454579">{{cite journal | vauthors = Kim HJ, Yi JY, Sung HS, Moore DD, Jhun BH, Lee YC, Lee JW | title = Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation | journal = Molecular and Cellular Biology | volume = 19 | issue = 9 | pages = 6323–32 | date = septembar 1999 | pmid = 10454579 | pmc = 84603 | doi = 10.1128/mcb.19.9.6323 }}</ref><ref name="pmid12612084">{{cite journal | vauthors = He B, Wilson EM | title = Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs | journal = Molecular and Cellular Biology | volume = 23 | issue = 6 | pages = 2135–50 | date = mart 2003 | pmid = 12612084 | pmc = 149467 | doi = 10.1128/MCB.23.6.2135-2150.2003 }}</ref>
* [[TADA3L]],<ref name="pmid12235159">{{cite journal | vauthors = Zeng M, Kumar A, Meng G, Gao Q, Dimri G, Wazer D, Band H, Band V | display-authors = 6 | title = Human papilloma virus 16 E6 oncoprotein inhibits retinoic X receptor-mediated transactivation by targeting human ADA3 coactivator | journal = The Journal of Biological Chemistry | volume = 277 | issue = 47 | pages = 45611–8 | date = novembar 2002 | pmid = 12235159 | doi = 10.1074/jbc.M208447200 | doi-access = free }}</ref> i
* [[ZBTB16]].<ref name="pmid14521715">{{cite journal | vauthors = Martin PJ, Delmotte MH, Formstecher P, Lefebvre P | title = PLZF is a negative regulator of retinoic acid receptor transcriptional activity | journal = Nuclear Receptor | volume = 1 | issue = 1 | pages = 6 | date = septembar 2003 | pmid = 14521715 | pmc = 212040 | doi = 10.1186/1478-1336-1-6 }}</ref>
{{Div col end}}

== Genetic Studies ==
Knock-out mice studies showed that a deletion in one of the copies of the RARA gene did not create any observable defect, while deletion of both copies shoes symptoms similar to that of Vitamin A deficiency. This proved that all 3 subtypes of RARs work redundantly.

== See also ==
* [[Retinoic acid receptor]]
*[[Retinoid X receptor|Retinoic X Receptor]]
* [[Acute promyelocytic leukemia]]

== Reference ==
{{Reflist}}

== Dopunska literatura ==
{{refbegin |33em}}
* {{cite journal | vauthors = Petkovich M, Brand NJ, Krust A, Chambon P | title = A human retinoic acid receptor which belongs to the family of nuclear receptors | journal = Nature | volume = 330 | issue = 6147 | pages = 444–50 | year = 1988 | pmid = 2825025 | doi = 10.1038/330444a0 | s2cid = 4271628 }}
* {{cite journal | vauthors = Sirulnik A, Melnick A, Zelent A, Licht JD | title = Molecular pathogenesis of acute promyelocytic leukaemia and APL variants | journal = Best Practice & Research. Clinical Haematology | volume = 16 | issue = 3 | pages = 387–408 | date = septembar 2003 | pmid = 12935958 | doi = 10.1016/S1521-6926(03)00062-8 }}
* {{cite journal | vauthors = Kliewer SA, Umesono K, Mangelsdorf DJ, Evans RM | title = Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling | journal = Nature | volume = 355 | issue = 6359 | pages = 446–9 | date = januar 1992 | pmid = 1310351 | pmc = 6159885 | doi = 10.1038/355446a0 | bibcode = 1992Natur.355..446K }}
* {{cite journal | vauthors = Kastner P, Perez A, Lutz Y, Rochette-Egly C, Gaub MP, Durand B, Lanotte M, Berger R, Chambon P | display-authors = 6 | title = Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins | journal = The EMBO Journal | volume = 11 | issue = 2 | pages = 629–42 | date = februar 1992 | pmid = 1311253 | pmc = 556495 | doi = 10.1002/j.1460-2075.1992.tb05095.x }}
* {{cite journal | vauthors = Baniahmad A, Köhne AC, Renkawitz R | title = A transferable silencing domain is present in the thyroid hormone receptor, in the v-erbA oncogene product and in the retinoic acid receptor | journal = The EMBO Journal | volume = 11 | issue = 3 | pages = 1015–23 | date = mart 1992 | pmid = 1347744 | pmc = 556542 | doi = 10.1002/j.1460-2075.1992.tb05140.x }}
* {{cite journal | vauthors = de Thé H, Lavau C, Marchio A, Chomienne C, Degos L, Dejean A | title = The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR | journal = Cell | volume = 66 | issue = 4 | pages = 675–84 | date = august 1991 | pmid = 1652369 | doi = 10.1016/0092-8674(91)90113-D | s2cid = 40272758 }}
* {{cite journal | vauthors = de Thé H, Chomienne C, Lanotte M, Degos L, Dejean A | title = The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus | journal = Nature | volume = 347 | issue = 6293 | pages = 558–61 | date = oktobar 1990 | pmid = 2170850 | doi = 10.1038/347558a0 | s2cid = 4314933 | bibcode = 1990Natur.347..558D }}
* {{cite journal | vauthors = Brand NJ, Petkovich M, Chambon P | title = Characterization of a functional promoter for the human retinoic acid receptor-alpha (hRAR-alpha) | journal = Nucleic Acids Research | volume = 18 | issue = 23 | pages = 6799–806 | date = decembar 1990 | pmid = 2175878 | pmc = 332734 | doi = 10.1093/nar/18.23.6799 }}
* {{cite journal | vauthors = Borrow J, Goddard AD, Sheer D, Solomon E | title = Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17 | journal = Science | volume = 249 | issue = 4976 | pages = 1577–80 | date = septembar 1990 | pmid = 2218500 | doi = 10.1126/science.2218500 | bibcode = 1990Sci...249.1577B }}
* {{cite journal | vauthors = Arveiler B, Petkovich M, Mandel JL, Chambon P | title = A PstI RFLP for the human retinoic acid receptor in 17q21 | journal = Nucleic Acids Research | volume = 16 | issue = 13 | pages = 6252 | date = juli 1988 | pmid = 2899875 | pmc = 336887 | doi = 10.1093/nar/16.13.6252 }}
* {{cite journal | vauthors = Chen JD, Evans RM | title = A transcriptional co-repressor that interacts with nuclear hormone receptors | journal = [[Nature]] | volume = 377 | issue = 6548 | pages = 454–7 | date = oktobar 1995 | pmid = 7566127 | doi = 10.1038/377454a0 | s2cid = 4361329 | bibcode = 1995Natur.377..454C }}
* {{cite journal | vauthors = Fisher GJ, Talwar HS, Xiao JH, Datta SC, Reddy AP, Gaub MP, Rochette-Egly C, Chambon P, Voorhees JJ | display-authors = 6 | title = Immunological identification and functional quantitation of retinoic acid and retinoid X receptor proteins in human skin | journal = The Journal of Biological Chemistry | volume = 269 | issue = 32 | pages = 20629–35 | date = august 1994 | doi = 10.1016/S0021-9258(17)32039-2 | pmid = 8051161 | doi-access = free }}
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{{refend}}

==Vanjski linkovi==
{{PDB Gallery|geneid=5914}}
{{Transkripcijski faktori|g2}}
{{Modulatori retinoidnog receptora}}
{{NLM content}}

{{DEFAULTSORT:Retinoic Acid Receptor Alpha}}
[[Kategorija:Geni na hromosomu 17]]
[[Kategorija:Unutarčelijski receptori]]
[[Kategorija:Transkripcijski faktori]]
[[Kategorija:Ljudski proteini]]
[[Kategorija:Proteomika]]