NLRC3

NLRC3
Identifikatori
Aliasi	NLRC3
Vanjski ID-jevi	OMIM: 615648 MGI: 2444070 HomoloGene: 18720 GeneCards: NLRC3
Lokacija gena (čovjek)
Hrom.	Hromosom 16 (čovjek)
Kraj	3,577,403 bp
Lokacija gena (miš)
Hrom.	Hromosom 16 (miš)
Kraj	3,794,496 bp
Ontologija gena
Molekularna funkcija	• nucleotide binding; • ATP binding; • GO:0001948, GO:0016582 vezivanje za proteine; • phosphatidylinositol 3-kinase regulatory subunit binding; • molekularna funkcija;
Ćelijska komponenta	• citoplazma; • centar organizacije mikrotubula; • citosol; • perinuklearno područje citoplazme;
Biološki proces	• negative regulation of interleukin-6 production; • negative regulation of tumor necrosis factor production; • I-kappaB kinase/NF-kappaB signaling; • negative regulation of NF-kappaB transcription factor activity; • T cell activation; • negative regulation of I-kappaB kinase/NF-kappaB signaling; • negative regulation of phosphatidylinositol 3-kinase signaling; • negative regulation of interferon-alpha production; • negative regulation of interferon-beta production; • negative regulation of innate immune response; • negative regulation of fibroblast proliferation; • negative regulation of epithelial cell proliferation; • negative regulation of inflammatory response; • negative regulation of cytokine production involved in inflammatory response; • negative regulation of NLRP3 inflammasome complex assembly; • negative regulation of NIK/NF-kappaB signaling; • GO:0007243 intracellular signal transduction;
	Izvori:Amigo / QuickGO
Ortolozi
	197358
	268857
	ENSG00000167984
	ENSMUSG00000049871
	Q7RTR2
	Q5DU56
	NM_178844
	NM_001081280; NM_175547
	NP_849172
	NP_001074749; NP_780756
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

NLRC3, skraćeno od NOD-liki receptor porodice CARD domena sa proteinom 3, je unurarćelijski protein koji ima ulogu u imunskom sistemu. To jest protein koji je kod ljudi kodiran genom sa p kraka hromosoma 16.^[5] Ranije je bio poznat kao nukleotidnovezujući domen oligomerizacije, ponavljanje bogato leucinom i CARD domen koji sadrži 3 (NOD3) i CLR16.2. NLRC3 inhibira aktivnost T-ćelija.^[6] NLRC3 takođe inhibira mTOR signalni put kako bi blokirao ćelijsku proliferaciju.^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1 065 aminokiselina, a molekulska težina 114.658 Da^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MRKQEVRTGR	EAGQGHGTGS	PAEQVKALMD	LLAGKGSQGS	QAPQALDRTP
DAPLGPCSND	SRIQRHRKAL	LSKVGGGPEL	GGPWHRLASL	LLVEGLTDLQ
LREHDFTQVE	ATRGGGHPAR	TVALDRLFLP	LSRVSVPPRV	SITIGVAGMG
KTTLVRHFVR	LWAHGQVGKD	FSLVLPLTFR	DLNTHEKLCA	DRLICSVFPH
VGEPSLAVAV	PARALLILDG	LDECRTPLDF	SNTVACTDPK	KEIPVDHLIT
NIIRGNLFPE	VSIWITSRPS	ASGQIPGGLV	DRMTEIRGFN	EEEIKVCLEQ
MFPEDQALLG	WMLSQVQADR	ALYLMCTVPA	FCRLTGMALG	HLWRSRTGPQ
DAELWPPRTL	CELYSWYFRM	ALSGEGQEKG	KASPRIEQVA	HGGRKMVGTL
GRLAFHGLLK	KKYVFYEQDM	KAFGVDLALL	QGAPCSCFLQ	REETLASSVA
YCFTHLSLQE	FVAAAYYYGA	SRRAIFDLFT	ESGVSWPRLG	FLTHFRSAAQ
RAMQAEDGRL	DVFLRFLSGL	LSPRVNALLA	GSLLAQGEHQ	AYRTQVAELL
QGCLRPDAAV	CARAINVLHC	LHELQHTELA	RSVEEAMESG	ALARLTGPAH
RAALAYLLQV	SDACAQEANL	SLSLSQGVLQ	SLLPQLLYCR	KLRLDTNQFQ
DPVMELLGSV	LSGKDCRIQK	ISLAENQISN	KGAKALARSL	LVNRSLTSLD
LRGNSIGPQG	AKALADALKI	NRTLTSLSLQ	GNTVRDDGAR	SMAEALASNR
TLSMLHLQKN	SIGPMGAQRM	ADALKQNRSL	KELMFSSNSI	GDGGAKALAE
ALKVNQGLES	LDLQSNSISD	AGVAALMGAL	CTNQTLLSLS	LRENSISPEG
AQAIAHALCA	NSTLKNLDLT	ANLLHDQGAR	AIAVAVRENR	TLTSLHLQWN
FIQAGAAQAL	GQALQLNRSL	TSLDLQENAI	GDDGACAVAR	ALKVNTALTA
LYLQVASIGA	SGAQVLGEAL	AVNRTLEILD	LRGNAIGVAG	AKALANALKV
NSSLRRLNLQ	ENSLGMDGAI	CIATALSGNH	RLQHINLQGN	HIGDSGARMI
SEAIKTNAPT	CTVEM

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167984 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049871 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ting JP, Lovering RC, Alnemri ES, et al. (mart 2008). "The NLR gene family: a standard nomenclature". Immunity. 28 (3): 285–7. doi:10.1016/j.immuni.2008.02.005. PMC 2630772. PMID 18341998.
^ ^a ^b Conti BJ, Davis BK, Zhang J, O'connor W, Williams KL, Ting JP (maj 2005). "CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function". J. Biol. Chem. 280 (18): 18375–85. doi:10.1074/jbc.M413169200. PMID 15705585.
^ Karki, Rajendra; Man, Si Ming; Malireddi, R. K. Subbarao; Kesavardhana, Sannula; Zhu, Qifan; Burton, Amanda R.; Sharma, Bhesh Raj; Qi, Xiaopeng; Pelletier, Stephane; Vogel, Peter; Rosenstiel, Philip (decembar 2016). "NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer". Nature. 540 (7634): 583–587. doi:10.1038/nature20597. ISSN 1476-4687. PMC 5468516. PMID 27951586.

Vanjski linkovi

Šablon:NOD receptori

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167984 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049871 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid18341998-5] Ting JP, Lovering RC, Alnemri ES, et al. (mart 2008). "The NLR gene family: a standard nomenclature". Immunity. 28 (3): 285–7. doi:10.1016/j.immuni.2008.02.005. PMC 2630772. PMID 18341998.

[pmid15705585-6] Conti BJ, Davis BK, Zhang J, O'connor W, Williams KL, Ting JP (maj 2005). "CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function". J. Biol. Chem. 280 (18): 18375–85. doi:10.1074/jbc.M413169200. PMID 15705585.

[7] Karki, Rajendra; Man, Si Ming; Malireddi, R. K. Subbarao; Kesavardhana, Sannula; Zhu, Qifan; Burton, Amanda R.; Sharma, Bhesh Raj; Qi, Xiaopeng; Pelletier, Stephane; Vogel, Peter; Rosenstiel, Philip (decembar 2016). "NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer". Nature. 540 (7634): 583–587. doi:10.1038/nature20597. ISSN 1476-4687. PMC 5468516. PMID 27951586.

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