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* Dr. Curt Connors appears in [[Sam Raimi]]'s [[Spider-Man (2002 film series)|''Spider-Man'' trilogy]], portrayed by [[Dylan Baker]]. This version is a former college classmate and friend of [[Otto Octavius (film character)|Otto Octavius]]' and a [[Columbia University]] physics professor who is concerned for [[Peter Parker (Sam Raimi film series)|Peter Parker]]'s well-being and academic performance in his [[quantum mechanics]] course. While Connors does not become the Lizard in this continuity, Raimi, Baker and producer Grant Curtis expressed interest in exploring the concept in sequels.<ref>{{cite news | first = Eric|last= Goldman | title = Exclusive: Lizard Leapin' Into Spidey 4? | publisher = [[IGN]] | date = January 23, 2007 | url = http://uk.movies.ign.com/articles/757/757729p1.html | access-date = May 29, 2007| url-status = dead| archive-url = https://web.archive.org/web/20081230040122/http://uk.movies.ign.com/articles/757/757729p1.html |archive-date = December 30, 2008}}</ref><ref>{{cite news|first=Sean |last=Elliott |title=Exclusive Interview: 'Spider-Man 3' Producer Grant Curtis talks about villains for 'Spidey 4' + His own origins — Part 1 |work=iF Magazine |date=May 29, 2008 |url=http://www.ifmagazine.com/feature.asp?article=2127 |access-date=May 29, 2008 |archive-url=https://web.archive.org/web/20070927224542/http://www.ifmagazine.com/feature.asp?article=2127 |archive-date=September 27, 2007 |url-status=dead }}</ref><ref name="raimivillains">{{cite news|first=Larry |last=Carroll |title=Sam Raimi May Not Helm 'Spider-Man 4'; Wants Carnage, Vulture As Villains If He Does |website=[[MTV.com]] |date=June 26, 2008 |url=http://www.mtv.com/movies/news/articles/1563359/20070625/story.jhtml?rsspartner=rssYahooNewscrawler |archive-url=https://web.archive.org/web/20110823185144/http://www.mtv.com/news/articles/1563359/sam-raimi-might-not-direct-spidey-4.jhtml?rsspartner=rssYahooNewscrawler |archive-date=August 23, 2011 |url-status=dead }}</ref>
* [[Rhys Ifans]] portrays Dr. Curt Connors / Lizard in two Marvel films.<ref>{{cite web | author=Jeff Sneider | url=http://www.thewrap.com/movies/column-post/exclusive-sony-new-spider-man-villain-lizard-21693 | title=Exclusive: Sony's New 'Spider-Man' Villain Is ... The Lizard! | website=Thewrap.com | date=October 13, 2010 | access-date=October 14, 2010 | archive-date=February 21, 2012 | archive-url=https://web.archive.org/web/20120221205354/http://www.thewrap.com/movies/column-post/exclusive-sony-new-spider-man-villain-lizard-21693 | url-status=dead }}</ref> This version is an Oscorp biologist and former partner of [[Richard and Mary Parker|Richard Parker]], whose research focused on genetically combining animal traits with humans to improve health. Additionally, Connors is a sympathetic yet misguided individual driven by the loss of his right arm and a desire to do genuine good while his Lizard alter-ego is more feral than most incarnations, but retains Connors' intelligence, does not wear clothes, and has a less pronounced snout, giving him a more humanoid appearance.
** Connors first appears in the Sony film ''[[The Amazing Spider-Man (film)|The Amazing Spider-Man]]'' (2012). [[Peter Parker (The Amazing Spider-Man film series)|Peter Parker]] finds Richard's notes and visits Connors to continue what he and Richard started. The two successfully formulate a serum together, which Connors injects himself with after being fired from Oscorp for refusing to rush into human trials. The serum regenerates Connors' lost arm, but eventually mutates him into the Lizard, who goes on a rampage until Spider-Man intervenes. Escaping into the sewer, he reverts back to his human self, but the effects of the serum has deeply corrupted his mind,
** Ifans reprised his role in the [[Marvel Cinematic Universe]] (MCU) film ''[[Spider-Man: No Way Home]]'' (2021).{{efn|Archive footage from ''The Amazing Spider-Man'' was used to portray Connors in his human form while Ifans voiced the Lizard throughout the film.}}<ref>{{Cite magazine|last=Coggan|first=Devan|date=November 16, 2021|title=New ''Spider-Man: No Way Home'' trailer swings headfirst into the multiverse|url=https://ew.com/movies/spider-man-no-way-home-new-trailer/|url-status=live|archive-url=https://web.archive.org/web/20211117024812/https://ew.com/movies/spider-man-no-way-home-new-trailer/|archive-date=November 17, 2021|access-date=November 16, 2021|magazine=[[Entertainment Weekly]]}}</ref> Sometime after learning Peter's secret identity, an alternate version of Connors is transported to
* The ''Spider-Gwen'' incarnation of Peter Parker / Lizard makes minor appearances in ''[[Spider-Man: Into the Spider-Verse]]'' (2018) and its sequel ''[[Spider-Man: Across the Spider-Verse]]'' (2023), being voiced by [[Jack Quaid]] in the latter film.<ref>{{cite web |last1=Pritchard |first1=Tom |title=The Best Easter Eggs and References We Spotted in Spider-Man: Into the Spider-Verse |url=http://www.gizmodo.co.uk/2018/12/the-best-easter-eggs-and-references-we-spotted-in-spider-man-into-the-spider-verse/ |website=Gizmodo.com |date=October 2, 2018 |access-date=December 12, 2018}}</ref><ref name="Spider-Verse">{{Cite web |last=Jasper |first=Gavin |date=2022-12-13 |title=Guide to the Weirdest Spider-Men in the Spider-Man: Across the Spider-Verse Trailer |url=https://www.denofgeek.com/movies/guide-to-weirdest-spider-men-in-spider-man-across-the-spider-verse-trailer |access-date=2022-12-13 |website=[[Den of Geek]] |language=en-US}}</ref>
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