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==Toxicity==
{{more citations needed section|date=June 2014}}
The milky exudation from the plant is a irritant poison.<ref>{{Textbook of medical jurisprudence, forencis medicine and toxicology|author=Parikh}}</ref> ''Calotropis'' species are poisonous plants; [[calotropin]], a compound in the latex, is more toxic than [[strychnine]].<ref>{{cite journal |author1=S. Morris Kupchan |author2=John R. Knox |author3=John E. Kelsey |author4=J. A. Saenz Renauld | title = Calotropin, a Cytotoxic Principle Isolated from Asclepias curassavica L | journal = Science | date = 25 December 1964|pmid=14224519 | volume=146 | issue=3652 | pages=1685–6 | doi=10.1126/science.146.3652.1685|bibcode=1964Sci...146.1685K |s2cid=31489685 }}</ref> Calotropin is similar in structure to two cardiac glycosides which are responsible for the cytotoxicity of ''[[Apocynum cannabinum]]''. Extracts from the flowers of ''Calotropis procera'' have shown strong [[cytotoxic]] activity. The extracts are also harmful to the eyes.
Cattle often stay away from the plants because of their unpleasant taste and their content of [[cardiac glycoside]]s.
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