Gluten-related disorders: Difference between revisions

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== Research ==
Research has attempted to discern, by [[double-blind placebo-controlled trial]]s, between a "fad component" to the recent popularity of the [[gluten-free diet]] and an actual sensitivity to gluten or other components of wheat.<ref name=FasanoSapone2015 /><ref name="CatassiBai2013" /><ref>{{cite journal |vauthors=Di Sabatino A, Volta U, Salvatore C, Biancheri P, Caio G, De Giorgio R, Di Stefano M, Corazza GR |title=Small Amounts of Gluten in Subjects with Suspected Nonceliac Gluten Sensitivity: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial |journal=Clinical Gastroenterology and Hepatology |volume=13 |issue=9 |pages=1604–12 |year=2015 |doi=10.1016/j.cgh.2015.01.029 |pmid=25701700|hdl=11392/2375087 |url=https://www.cghjournal.org/article/S1542-3565(15)00153-6/fulltext }}</ref>
 
In a 2013 [[blind experiment#Double-blind trials|double-blind]], [[placebo-controlled study|placebo-controlled]] challenge (DBPC) by Biesiekierski ''et al.'' in a few people with [[irritable bowel syndrome]], the authors found no difference between gluten or placebo groups and the concept of NCGS as a syndrome was questioned. Nevertheless, this study had design errors and an incorrect selection of participants, and probably the reintroduction of both gluten and [[whey]] protein had a [[nocebo]] effect similar in all people, and this could have masked the true effect of gluten/wheat reintroduction.<ref name=ElliBranchi /><ref name="AzizHadjivassiliou2015" />