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* [[Rhys Ifans]] portrays Dr. Curt Connors / Lizard in two Marvel films.<ref>{{cite web | author=Jeff Sneider | url=http://www.thewrap.com/movies/column-post/exclusive-sony-new-spider-man-villain-lizard-21693 | title=Exclusive: Sony's New 'Spider-Man' Villain Is ... The Lizard! | website=Thewrap.com | date=October 13, 2010 | access-date=October 14, 2010}}</ref> This version is an Oscorp biologist and former partner of [[Richard and Mary Parker|Richard Parker]], whose research focused on genetically combining animal traits with humans to improve health. Additionally, Connors is a sympathetic yet misguided individual driven by the loss of his right arm and a desire to do genuine good while his Lizard alter-ego is more feral than most incarnations, but retains Connors' intelligence, does not wear clothes, and has a less pronounced snout, giving him a more humanoid appearance.
** Connors first appears in the Sony film ''[[The Amazing Spider-Man (film)|The Amazing Spider-Man]]'' (2012). [[Peter Parker (The Amazing Spider-Man film series)|Peter Parker]] finds Richard's notes and visits Connors to continue what he and Richard started. The two successfully formulate a serum together, which Connors injects himself with after being fired from Oscorp for refusing to rush into human trials. The serum regenerates Connors' lost arm, but eventually mutates him into the Lizard, who goes on a rampage until Spider-Man intervenes. Escaping into the sewer, he reverts, develops an obsession with his abilities, builds a makeshift off-site lab, and experiments on himself further due to the chemicals affecting his mind. The Lizard discovers Spider-Man's secret identity, develops a mind of his own, and asserts himself as the dominant personality while seeking to mutate all of New York into lizards like himself. However, Spider-Man foils his plan with Captain [[George Stacy]]'s help and cures him. With the Lizard's personality gone and his sanity restored, Connors saves Peter from plummeting off of Oscorp Tower and surrenders to the authorities. In the film's [[post-credits scene|mid-credits scene]], Connors is remanded to Beloit Psychiatric Hospital, where he speaks with the [[Gentleman (character)|Gentleman]] regarding the Parkers' knowledge of him.
** Ifans reprised his role in the [[Marvel Cinematic Universe]] (MCU) film ''[[Spider-Man: No Way Home]]'' (2021).{{efn|Archive footage from ''The Amazing Spider-Man'' was used to portray Connors in his human form while Ifans voiced the Lizard throughout the film.}}<ref>{{Cite magazine|last=Coggan|first=Devan|date=November 16, 2021|title=New ''Spider-Man: No Way Home'' trailer swings headfirst into the multiverse|url=https://ew.com/movies/spider-man-no-way-home-new-trailer/|url-status=live|archive-url=https://web.archive.org/web/20211117024812/https://ew.com/movies/spider-man-no-way-home-new-trailer/|archive-date=November 17, 2021|access-date=November 16, 2021|magazine=[[Entertainment Weekly]]}}</ref> Sometime after learning Peter's secret identity, Connors is transported to another universe, where he is found and imprisoned by [[Stephen Strange (Marvel Cinematic Universe)|Doctor Strange]] alongside other alternate universe-displaced supervillains and encounters its version of [[Peter Parker (Marvel Cinematic Universe)|Peter Parker]], who offers to cure them
* The ''Spider-Gwen'' incarnation of Peter Parker / Lizard makes cameo appearances in ''[[Spider-Man: Into the Spider-Verse]]'' and ''[[Spider-Man: Across the Spider-Verse]]''
===Video games===
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