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'''SLU-PP-332''' is a compound which is a potent but non-selective [[estrogen -related receptor]] (ERR) [[agonist]], acting most strongly at [[Estrogen-related receptor alpha|ERRα]] with an EC<sub>50</sub> of 98 nM. It was found to counteract [[metabolic syndrome]] in mice, suggesting a possible role for compounds from this class as [[Anti-obesity medication|medications for the treatment of obesity]].<ref>{{cite patent | url = https://patents.google.com/patent/US8680150B2/en?oq=US8680150 | inventor = Zhi L, Hudson AR, Van Oeveren CA, Roach SL, Pickens JC, Shen Y, Cuervo C, Valdez LJ, Basinger J, Grant VH | title = Small molecule hematopoietic growth factor mimetic compounds that activate hematopoietic growth factor receptors. | country = US | number = 8680150 | gdate = 25 March 2014 | assign1 = Ligand Pharmaceuticals Inc. }}</ref><ref name="pmid36988910">{{cite journal | vauthors = Billon C, Sitaula S, Banerjee S, Welch R, Elgendy B, Hegazy L, Oh TG, Kazantzis M, Chatterjee A, Chrivia J, Hayes ME, Xu W, Hamilton A, Huss JM, Zhang L, Walker JK, Downes M, Evans RM, Burris TP | display-authors = 6 | title = Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity | journal = ACS Chemical Biology | volume = 18 | issue = 4 | pages = 756–771 | date = April 2023 | pmid = 36988910 | doi = 10.1021/acschembio.2c00720 | s2cid = 257803892 }}</ref><ref name="pmid37739806">{{cite journal | vauthors = Billon C, Schoepke E, Avdagic A, Chatterjee A, Butler AA, Elgendy B, Walker JK, Burris TP | display-authors = 6 | title = A Synthetic ERR Agonist Alleviates Metabolic Syndrome | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 388| issue = 2| date = September 2023 | pages = 232–240 | pmid = 37739806 | doi = 10.1124/jpet.123.001733 | s2cid = 262147173 | doi-access = free }}</ref><ref name="pmid37717940">{{cite journal | vauthors = Wang XX, Myakala K, Libby AE, Krawczyk E, Panov J, Jones BA, Bhasin K, Shults N, Qi Y, Krausz KW, Zerfas PM, Takahashi S, Daneshpajouhnejad P, Titievsky A, Taranenko E, Billon C, Chatterjee A, Walker JK, Albanese C, Kopp JB, Rosenberg AZ, Gonzalez FJ, Guha U, Brodsky L, Burris TP, Levi M | display-authors = 6 | title = Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney | journal = The American Journal of Pathology | volume = 193| issue = 12| date = September 2023 | pages = 1969–1987 | pmid = 37717940 | doi = 10.1016/j.ajpath.2023.07.008 | pmc = 10734281 | pmc-embargo-date = December 1, 2024 | s2cid = 262046570 }}</ref><ref>{{cite web |title=Exercise-mimicking drug sheds weight, boosts muscle activity in mice |url=https://news.ufl.edu/2023/09/exercise-mimicking-drug/ |access-date=2023-10-05 |website=news.ufl.edu |language=en}}</ref>
==References==
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