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After his return to civilian life as a research technologist, Connors became obsessed with uncovering the secrets of reptilian limb regeneration. Working from his home in the [[Florida]] [[Everglades]] with the help of war buddy [[Man-Thing|Ted Sallis]], he finally developed an experimental serum taken from [[Reptile|reptilian]] [[DNA]].<ref name="Web of Spider-Man vol. 2, #6" /> The serum successfully regrew the missing limb of a rabbit, so then Connors chose to test the serum on himself. He ingested the formula and he did indeed grow a new arm.
However, the formula had an unfortunate [[side effect]]: Connors was subsequently transformed into a [[reptilian humanoid]] monster.<ref>{{cite book |last=Rovin |first=Jeff |title=[[The Encyclopedia of Super-Villains]] |date=1987 |publisher=Facts on File |isbn=0-8160-1356-X |location=New York |
===Life in New York===
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* [[Alternative versions of Spider-Man#Earth-65|Peter Parker]] became Lizard.<ref>{{cite web|url=http://www.comicbookresources.com/?page=article&id=53261|title=Lowe, Hine & Latour Take Readers to the "Edge of Spider-Verse"|date=June 6, 2014|website=Comicbookresources.com|access-date=October 23, 2018}}</ref>
* [[Harry Osborn#Spider-Gwen|Harry Osborn]] later became Lizard to avenge Peter Parker.<ref>''Spider-Gwen'' Vol. 2 #22. Marvel Comics.</ref>
* It is later revealed that Curt Connors was a teacher at Gwen's high school and was studying Lizard genetics, possibly being involved in Peter's transformation into the Lizard and the recent sightings of multiple Lizard-people wreaking havoc in the city.<ref>''Spider-Gwen'' Vol. 2 #1. Marvel Comics.</ref> The organization S.I.L.K. was responsible for abducting Lizard as Earth-65's Cindy Moon used him as a test subject for his own formula causing him to be turned into the next Lizard.<ref>''Spider-Gwen'' Vol. 2 #4. Marvel Comics.</ref>
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* The Lizard appears as a playable character in ''[[Marvel: Future Fight]]''.{{citation needed|date=July 2017}}
* Curt Connors / Lizard appears as a playable character in ''[[Lego Marvel Super Heroes 2]]''.<ref>{{cite web|title=Characters|url=http://m.ign.com/wikis/lego-marvel-super-heroes-2/Characters|website=IGN Database|date=May 19, 2017 |access-date=January 28, 2018}}</ref>
* Curt Connors appears in [[Insomniac Games]]' ''[[Spider-Man (Insomniac Games series)|Spider-Man]]'' series.<ref name="gamerant.com">{{cite web | url=https://gamerant.com/spider-man-miles-morales-post-credits-ending-peter-parker-venom-sequel/ | title=Spider-Man: Miles Morales Post Credits Scene Explained, and How it Sets up Spider-Man 2 | date=November 26, 2020 }}</ref> This version is an Oscorp scientist working for [[Norman Osborn]] and personal physician to his terminally-ill son [[Harry Osborn]] who previously fought Spider-Man as the Lizard until the web-slinger cured him years prior.
** Connors first appears in the mid-credits scene of ''[[Spider-Man: Miles Morales]]'', voiced by an uncredited voice actor. Connors monitors Harry until Norman orders him to release the latter despite the potential danger, which Connors reluctantly complies with.<ref
** Connors / Lizard appears as a boss in ''[[Spider-Man 2 (2023 video game)|Spider-Man 2]]'' (2023), voiced by Mark Whitten.<ref>{{cite web |last1=Whitten |first1=Mark |title=Bursting out of my skin with excitement to share that I play Dr. Curt Connors (aka #TheLizard) in #SpiderMan2PS5! Big thx to the stellar @insomniacgames team and my reps @deanpanarotalent. Loved working with y'all, and this amazing cast!! Can't wait to dive in October 20th! |url=https://www.instagram.com/p/CyRDtJVJLUW/?igshid=MzRlODBiNWFlZA%3D%3D |website=Instagram |access-date=12 October 2023}}</ref><ref>{{cite web | url=https://thedirect.com/article/spider-man-2-ps5-lizard-kraven-photos | title=Spider-Man 2 PS5: First Look at Lizard & Kraven Revealed (Photos) | date=May 24, 2023 }}</ref> In a flashback, Connors lost his arm while accompanying Oscorp in procuring a meteorite containing the [[Venom (character)|Venom]] symbiote years prior, which Norman would later use on Harry. Additionally, Connors' family left him after he first became the Lizard. In the present, Connors continues to monitor Harry for adverse side effects until Kraven the Hunter kidnaps and forces Connors to turn back into the Lizard so he can hunt him. After bonding with the symbiote, Spider-Man works to find and cure Connors to save Harry. Upon being cured, Connors attempts to convince Spider-Man to remove and destroy the symbiote due to its negative influence before working with him to thwart a symbiote invasion.
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