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| ''[[Citrobacter]]'' infection || bgcolor="#488ED3"|Normal<ref name="''Citrobacter'' infection">{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBTX/citrobacter-challenge/ |title=''Citrobacter'' infection data for Dscc1 |publisher=Wellcome Trust Sanger Institute}}</ref>
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| colspan=2; style="text-align: center;" | All tests and analysis from<ref name="mgp_reference">{{cite journal |
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[[Model organism]]s have been used in the study of DSCC1 function. A conditional [[knockout mouse]] line, called ''Dscc1<sup>tm1a(KOMP)Wtsi</sup>''<ref name="allele_ref">{{cite web |url=http://www.knockoutmouse.org/martsearch/search?query=Dscc1 |title=International Knockout Mouse Consortium}}</ref><ref name="mgi_allele_ref">{{cite web |url=http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4362627 |title=Mouse Genome Informatics}}</ref> was generated at the [[Wellcome Trust Sanger Institute]] as part of the [[International Knockout Mouse Consortium]] program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.<ref name="pmid21677750">{{Cite pmid|21677750}}</ref><ref name="mouse_library">{{cite journal | doi = 10.1038/474262a | title = Mouse library set to be knockout | year = 2011 | author = Dolgin E | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | pmid = 21677718 }}</ref><ref name="mouse_for_all_reasons">{{cite journal | doi = 10.1016/j.cell.2006.12.018 | title = A Mouse for All Reasons | year = 2007 | journal = Cell | volume = 128 | pages = 9–13 | pmid = 17218247 |author=Collins FS, Rossant J, Wurst W| issue = 1 }}</ref>
Male and female animals underwent a standardized [[phenotypic screen]] to determine the effects of deletion.<ref name="mgp_reference" /><ref name="pmid21722353">{{cite journal| author=van der Weyden L, White JK, Adams DJ, Logan DW| title=The mouse genetics toolkit: revealing function and mechanism. | journal=Genome Biol | year= 2011 | volume= 12 | issue= 6 | pages= 224 | pmid=21722353 | doi=10.1186/gb-2011-12-6-224 | pmc=3218837}} </ref> Twenty four tests were carried out on [[mutant]] mice and four significant abnormalities were observed.<ref name="mgp_reference" /> Few [[homozygous]] mutant embryos were identified during gestation, and some displayed [[oedema]], therefore less than expected survived until [[weaning]]. Those that did survive had increased chromosomal instability in a [[micronucleus test]] and numerous skeletal abnormalities by [[radiography]].<ref name="mgp_reference" />
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