Wikipedia

High-fructose corn syrup

This is an old revision of this page, as edited by Shrampes (talk | contribs) at 02:42, 9 December 2008 (this source is not compliant with WP:V). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

High-fructose corn syrup (HFCS) - in Europe called isoglucose[1] - comprises any of a group of corn syrups that has undergone enzymatic processing to increase its fructose content, and is then mixed with pure corn syrup (100% glucose), becoming a high-fructose corn syrup. HFCS is used in various types of food, from soft drinks and yogurt to cookies, salad dressing and tomato soup.[2]

Most common types of High-fructose corn syrup are: HFCS 90 (mostly for making HFCS 55), approximately 90% fructose and 10% glucose; HFCS 55 (mostly used in soft drinks), approximately 55% fructose and 45% glucose; and HFCS 42 (used in most foods and baked goods), approximately 42% fructose and 58% glucose.[3]

The process by which HFCS is produced was first developed by Richard Off. Marshalle and Earl P. Kooi in 1927.[4] The industrial production process was refined by Dr. Y. Takasaki at Agency of Industrial Science and Technology of Ministry of International Trade and Industry of Japan in 1965-1970. HFCS was rapidly introduced to many processed foods and soft drinks in the U.S. from about 1975 to 1985.

Per relative sweetness, HFCS 55 is comparable to table sugar (sucrose), a disaccharide of fructose and glucose.[5] That makes it useful to food manufacturers as a substitute for sucrose in soft drinks and processed foods. HFCS 90 is sweeter than sucrose, HFCS 42 is less sweet than sucrose.

Use as a replacement for sugar

Since its introduction, HFCS has begun to replace sugar in various processed foods in the USA and Canada.[6][7] The main reasons for this switch are:[8]

  • HFCS is somewhat cheaper in the United States due to a combination of corn subsidies and sugar tariffs.[9] Since the mid-90s US Federal subsidies to corn growers have amounted to $40 billion.[10]
  • HFCS is easier to blend and transport because it is a liquid.[11]

Comparison to other sugars

Cane and beet sugar

Cane sugar and Beet sugar are both relatively pure sucrose. While the glucose and fructose which are the two components of HFCS are monosaccharides, sucrose is a disaccharide composed of glucose and fructose linked together with a relatively weak glycosidic bond. A molecule of sucrose (with a chemical formula of C12H22O11) can be broken down into a molecule of glucose (C6H12O6) plus a molecule of fructose (also C6H12O6 — an isomer of glucose) in a weakly acidic environment[citation needed]. Sucrose is broken down during digestion into fructose and glucose through hydrolysis by the enzyme sucrase, by which the body regulates the rate of sucrose breakdown. Without this regulation mechanism, the body has less control over the rate of sugar absorption into the bloodstream.

The fact that sucrose is composed of glucose and fructose units chemically bonded complicates the comparison between cane sugar and HFCS. Sucrose, glucose and fructose are unique, distinct molecules. Sucrose is broken down into its constituent monosaccharides—namely, fructose and glucose—in weakly acidic environments by a process called inversion.[12]. This same process occurs in the stomach and in the small intestine during the digestion of sucrose into fructose and glucose. People with sucrase deficiency cannot digest (break down) sucrose and thus exhibit sucrose intolerance.[13]

Both HFCS and sucrose have approximately 4 kcal per gram of solid if the HFCS is dried; HFCS has approximately 3 kcal per gram in its liquid form.[citation needed]

Honey

Honey is a mixture of different types of sugars, water, and small amounts of other compounds. Honey typically has a fructose/glucose ratio similar to HFCS 55, as well as containing some sucrose and other sugars. Honey, HFCS and sucrose have the same number of calories, having approximately 4 kcal per gram of solid; honey and HFCS both have about 3 kcal per gram in liquid form. Because of its similar sugar profile and its lower price HFCS has been used illegally to "stretch" honey. As a result checks for adulteration no longer test for sugar but instead test for minute quantities of proteins that can be used to differentiate between HFCS and honey [14].

Production

High-fructose corn syrup is produced by milling corn to produce corn starch, then processing that corn starch to yield corn syrup which is almost entirely glucose, and then adding enzymes which change the glucose into fructose. The resulting syrup (after enzyme conversion) contains approximately 90% fructose and is HFCS 90. To make the other common forms of HFCS (HFCS 55 and HFCS 42) the HFCS 90 is mixed with 100% glucose corn syrup in the appropriate ratios to form the desired HFCS. The enzyme process which changes the 100% glucose corn syrup into HFCS 90 is as follows:

  1. Cornstarch is treated with alpha-amylase to produce shorter chains of sugars called oligosaccharides.
  2. Glucoamylase breaks the sugar chains down even further to yield the simple sugar glucose.
  3. Xylose isomerase (aka glucose isomerase) converts glucose to a mixture of about 42% fructose and 50–52% glucose with some other sugars mixed in.

While inexpensive alpha-amylase and glucoamylase are added directly to the slurry and used only once, the more costly glucose-isomerase is packed into columns and the sugar mixture is then passed over it, allowing it to be used repeatedly until it loses its activity. This 42–43% fructose glucose mixture is then subjected to a liquid chromatography step where the fructose is enriched to approximately 90%. The 90% fructose is then back-blended with 42% fructose to achieve a 55% fructose final product. Most manufacturers use carbon absorption for impurity removal. Numerous filtration, ion-exchange and evaporation steps are also part of the overall process.

Measuring concentration of HFCS

The units of measurement for sugars including HFCS are degrees Brix (symbol °Bx). Brix is a measurement of the mass ratio of dissolved sugars to water in a liquid. A 25 °Bx solution has 25 grams of sugar per 100 grams of liquid (25% w/w). Or, to put it another way, there are 25 grams of sugar and 75 grams of water in the 100 grams of solution. The Brix measurement was introduced by Antoine Brix.

When an infrared Brix sensor is used, it measures the vibrational frequency of the high-fructose corn syrup molecules, giving a Brix degrees measurement. This will not be the same measurement as Brix degrees using a density or refractive index measurement because it will specifically measure dissolved sugar concentration instead of all dissolved solids. When a refractometer is used, it is correct to report the result as "refractometric dried substance" (RDS). One might speak of a liquid as being 20 °Bx RDS. This is a measure of percent by weight of total dried solids and, although not technically the same as Brix degrees determined through an infrared method, renders an accurate measurement of sucrose content since the majority of dried solids are in fact sucrose. The advent of in-line infrared Brix measurement sensors have made measuring the amount of dissolved HFCS in products economical using a direct measurement. It also gives the possibility of a direct volume/volume measurement.

Recently an isotopic method for quantifying sweeteners derived from corn and sugar cane was developed by Jahren et al. which permits measurement of corn syrup and cane sugar derived sweeteners in humans thus allowing dietary assessment of the intake of these substances relative to total intake.[15]

Sweetener consumption patterns

In the United States

 
US sweetener consumption, 1966-2004. It is apparent from this graph that overall sweetener consumption, and in particular glucose-fructose mixtures, has increased since the introduction of HFCS. Thus, the amount of fructose consumed in the United States has increased since the early 1980s. This would be true whether the added sweetener was HFCS, table sugar, or any other glucose-fructose mixture. However, because HFCS has slightly more fructose than does table sugar, the proportion of fructose as a component of overall sweetener intake in the United States has also increased, which would not be true if the increase in overall intake was table sugar.

A system of tariffs and sugar quotas imposed in 1977 significantly increased the cost of importing sugar, and producers sought a cheaper alternative. High-fructose corn syrup, derived from corn, is more economical because the American and Canadian prices of sugar are twice the global price of sugar[16] and the price of #2 corn is artificially low due to both government subsidies and dumping on the market as farmers produce more corn annually.[17][18] HFCS became an attractive substitute, and is preferred over cane sugar among the vast majority of American food and beverage manufacturers. For instance, soft drink makers like Coca-Cola and Pepsi use sugar in other nations, but switched to HFCS in the U.S. in 1984.[19] Large corporations, such as Archer Daniels Midland, lobby for the continuation of these subsidies.[20]

Other countries, including Mexico, typically use sugar in soft drinks. Some Americans seek out Mexican Coke in ethnic groceries, because they feel it tastes better or is healthier than Coke made with HFCS, and because they believe it will have less effect on obesity. [5]

The average American consumed approximately 28.4 kg of HFCS in 2005, versus 26.7 kg of sucrose sugar.[21] In countries where HFCS is not used or rarely used, sucrose consumption per person may be higher than in the USA; Sucrose consumption per person from various locations is shown below (2002):[22]

  • USA: 32.4 kg
  • EU: 40.1 kg
  • Brazil: 59.7 kg
  • Australia: 56.2 kg

Of course, in terms of total sugars consumed, the figures from countries where HFCS is not used should be compared to the sum of the sucrose and HFCS figures from countries where HFCS consumption is significant.

International markets

In the European Union (EU), HFCS, known as isoglucose, has been subject to production quotas since 1977.[citation needed] Production of isoglucose in the EU has been limited to 507,000 metric tons, equivalent to about 2%-3% of sugar production. Therefore, wide scale replacement of sugar has not occurred in the EU. In Japan, HFCS consumption accounts for one quarter of total sweetener consumption.[23]

Health effects

There are indications that soda and sweet drinks provide a greater proportion of daily calories than any other food in the American diet.

Overconsumption of sugars has been linked to adverse health effects, such as obesity, and most of these effects are similar for HFCS and sucrose. There is a correlation between the rise of obesity in the U.S. and the use of HFCS for sweetening beverages and foods.Cite error: A <ref> tag is missing the closing </ref> (see the help page).

The controversy largely comes down to whether this is coincidence or a causal relationship. Some critics of HFCS do not claim that it is any worse than similar quantities of sucrose would be, but rather focus on its prominent role in the overconsumption of sugar; for example, encouraging overconsumption through its low cost. Others, like the Corn Refiners Association, claim that high fructose corn syrup "has the same natural sweeteners as table sugar" and is natural.[24]

The possible difference in health effects between sucrose and HFCS could come from the difference in chemical make up between them. HFCS 55 (the type most commonly used in soft drinks) is made up of 55% fructose and 45% glucose. By contrast, sucrose is made up of 50% fructose and 50% glucose, when broken down by adding a water molecule.[25]

Furthermore, the fructose and glucose in HFCS 55 are in the form of separate molecules; by contrast, the fructose and glucose that are contained in sucrose are joined together to form a single molecule (called a disaccharide). This chemical difference may be less significant in many beverages that are sweetened with sucrose. This is because many beverages are strongly acidic, and the acid in the beverage will cause the sucrose to separate into its component parts of glucose and fructose. The amount of sucrose converted will depend on the temperature the beverage is kept at and the amount of time it is kept at this temperature.[citation needed]

There are a number of relevant studies published in peer reviewed journals suggesting a link between high fructose diets and adverse health effects. For example, studies on the effect of fructose, as reviewed by Elliot et al.,[26] implicate increased consumption of fructose (due primarily to the increased consumption of sugars but also partly due to the slightly higher fructose content of HFCS as compared to sucrose) in obesity and insulin resistance. Chi-Tang Ho et al. found that soft drinks sweetened with HFCS are up to 10 times richer in harmful carbonyl compounds, such as methylglyoxal, than a diet soft drink control.[27] Carbonyl compounds are elevated in people with diabetes and are blamed for causing diabetic complications such as foot ulcers and eye and nerve damage;[28][29]

Furthermore, a study in mice suggests that fructose increases obesity.[30] Large quantities of fructose stimulate the liver to produce triglycerides, promotes glycation of proteins and induces insulin resistance.[31] According to one study, the average American consumes nearly 70 pounds of HFCS per annum, marking HFCS as a major contributor to the rising rates of obesity in the last generation. [32]

A 2007 study also raised concerns of possible liver damage as a result of HFCS in combination with a high fat diet and a sedentary lifestyle.[33]

In contrast to the above studies other papers (some of which were funded by corn refiners or the American Beverage Institute[citation needed]) suggest HFCS has no ill health effects. A review supported by Tate & Lyle, a large corn refiner which makes a significant profit from the sale of corn-based products, concluded "that HFCS does not appear to contribute to overweight and obesity any differently than do other energy sources."[34]

In addition, some of the above-referenced studies have addressed fructose specifically, not sweeteners such as HFCS or sucrose which contain fructose in combination with other sugars. Thus, although they indicate that high fructose intake should be avoided, they don't necessarily indicate that HFCS is worse than sucrose intake, except insofar as HFCS contains 10% more fructose. Studies which have compared HFCS to sucrose (as opposed to pure fructose) find that they have essentially identical physiological effects. For instance, Melanson et al. (2006), studied the effects of HFCS and sucrose sweetened drinks on blood glucose, insulin, leptin, and ghrelin levels. They found no significant differences in any of these parameters.[35] Accounts are conflicting however, as another source claims that HFCS actually does affect leptin, causing the body to not know how to stop eating, or when to start digesting food.[36]

A typical soda contains 23 grams of fructose. [37]. An average 100g apple contains 5.9 grams of fructose.[citation needed] Therefore, a consumer would need to eat over 3 and a half apples to ingest the fructose contained in one can of soda since fructose concentration is higher in the soda compared to the fruit. Because of this, the levels of fructose in the typical American diet, which consists of many HFCS foods, are on average higher given the high concentration of fructose in HFCS foods and the prevalence of HFCS foods in the American diet. Therefore the studies which show the ill effects of fructose do apply to HFCS when you take into account these considerations. Of course chemically there is no difference between fructose from a fruit or fructose from HFCS, but HFCS being consumed heavily in a diet means American consumers are ingesting more fructose compared to a diet which substitutes HFCS with fruit.

Perrigue et al. (2006) compared the effects of isocaloric servings of colas sweetened with HFCS 45, HFCS 55, sucrose, and aspartame on satiety and subsequent energy intake[citation needed]. They found that all of the drinks with caloric sweeteners produced similar satiety responses, and had the same effects on subsequent energy intake. Taken together with Melanson et al. (2006), this study suggests that there is little or no evidence for the hypothesis that HFCS is different from sucrose in its effects on appetite or on metabolic processes involved in fat storage.

It should be noted that both the Perrigue et al. study and the Melanson et al. study were funded by "the American Beverage Institute and the Corn Refiners Association."[38][39] suggesting a possible conflict of interest in regards to the study of HFCS.

One much-publicized 2004 study found an association between obesity and high HFCS consumption, especially from soft drinks.[40] However, this study provided only correlative data. One of the study coauthors, Dr. Barry M. Popkin, is quoted in the New York Times as saying, "I don't think there should be a perception that high-fructose corn syrup has caused obesity until we know more."[41] In the same article, Walter Willett, chair of the nutrition department of the Harvard School of Public Health, is quoted as saying, "There's no substantial evidence to support the idea that high-fructose corn syrup is somehow responsible for obesity .... If there was no high-fructose corn syrup, I don't think we would see a change in anything important." Willett also recommends drinking water over soft drinks containing sugars or high-fructose corn syrup.[42]

A study published recently suggests that the consumption of high fructose corn syrups may be linked to leptin resistance in the body. High fructose corn syrups are inexpensive, extremely sweet and extend the shelf life of processed foods, making this a very popular food additive since the early 1980s. Overconsumption of the syrup can lead to weight gain through its suppression of feelings of fullness leading a person to consume more calories than required. [43][44]

Labeling as "natural"

In May 2006, the Center for Science in the Public Interest (CSPI) threatened to file a lawsuit against Cadbury Schweppes for labeling 7 Up as "All Natural"[45] or "100% Natural",[46] despite containing high-fructose corn syrup. While the U.S. FDA has no definition of "natural", CSPI claims that HFCS is not a “natural” ingredient due to the high level of processing and the use of at least one genetically modified (GMO) enzyme required to produce it.[47] On January 12, 2007, Cadbury Schweppes agreed to stop calling 7 Up "All Natural".[48] They now label it "100% Natural Flavors".[49]

Snapple (another Cadbury-Schweppes brand) is well-known for being labeled "all-natural", but most varieties contain HFCS. Newman's Own Lemonade [50] and [51] Limeade are labeled as "all-natural" but also contain HFCS. Bread produced by Nature's Own Bread is labeled as having "no artificial preservatives, colors, or flavors", though some varieties contain HFCS.[52] Still, as the U.S. FDA has no general definition of "natural", a company may refer to its product as "all natural", regardless of the ingredients, in most cases. However, FDA does prohibit beverages that contain less than 100% juice from using phrases like 100% natural and 100% pure. 21 CFR 101.35(l) This might apply to 7UP based on vignettes of lemon, lime, or other fruit which could be construed as purporting to contain juice.

Despite the lawsuit from CSPI, the FDA released this letter to the Corn Refiners Association saying HFCS can be labeled as natural.[citation needed]

Television ads

In September 2008, the Corn Refiners Association[53] launched a series of United States television advertisements that claim that HFCS "is made from corn", "doesn't have artificial ingredients", "has the same calories as sugar or honey", "is nutritionally the same as sugar", and "is fine in moderation". The ads feature actors portraying roles in upbeat domestic situations with sugary foods, with one actor disparaging a food's HFCS content but being unable to explain why, and another actor rebuking the comments with these claims. Finally, the ads each advertise the URL http://www.sweetsurprise.com/ with more information provided by the Corn Refiners Association.[6][7] As HFCS is a controversial topic, parodies and criticisms of the ads have appeared on YouTube.[8][9][10]

Taste

Some beverage manufacturers, such as Jones Soda, Eldorado Organic Vitamin Charged Spring Water, Goose Island Brewery, Steaz, Abita Root Beer and Dublin Dr Pepper, use sugar rather than high fructose corn syrup in their products. These companies maintain in their advertising that there is a noticeable difference in taste between the two sweeteners.

References

  1. ^ Oxford Dictionary of Biochemistry and Molecular Biology, Oxford University Press, 2006 (page 311)
  2. ^ New York Times "A Sweetener With a Bad Rap", 2 June 2006
  3. ^ University of Maryland press release UM. Study - Not Enough Evidence to Indict High Fructose Corn Syrup in Obesity Accessed 2007-11-15
  4. ^ Marshall; et al. (1957). "Enzymatic Conversion of d-Glucose to d-Fructose". Science. 125 (3249): 648. doi:10.1126/science.125.3249.648. PMID 13421660. {{cite journal}}: Explicit use of et al. in: |author= (help)
  5. ^ High Fructose Corn Syrup is Not Sweeter Than Sugar?
  6. ^ (Bray, 2004 & U.S. Department of Agriculture, Economic Research Service, Sugar and Sweetener Yearbook series, Tables 50–52)
  7. ^ Statistics Canada, 2007
  8. ^ (White JS. 1992. Fructose syrup: production, properties and applications, in FW Schenck & RE Hebeda, eds, Starch Hydrolysis Products – Worldwide Technology, Production, and Applications. VCH Publishers, Inc. 177-200)
  9. ^ Pollan, M., The (Agri)Cultural Contradictions Of Obesity, NY Times Magazine, 12 Oct. 2003.
  10. ^ Encyclopedia of Junk Food and Fast Food, Andrew F. Smith, Greenwood Publishing Group, 2006 (page 258)
  11. ^ (Hanover LM, White JS. 1993. Manufacturing, composition, and applications of fructose. Am J Clin Nutr 58(suppl 5):724S-732S.)
  12. ^ Sugar Confectionery Manufacture, E. B. Jackson, Springer, 1995, ISBN 0834212978 (page 109 and 115)
  13. ^ Intestinal sucrase deficiency presenting as sucrose intolerance in adult life, Br Med J. 1965 November 20; 2(5472): 1223–1225.
  14. ^ From where I Sit: Essays on Bees, Beekeeping, and Science, Mark L. Winston, Cornell University Press, 1998, ISBN 0801484782 (page 109)
  15. ^ [1]
  16. ^ Grist ADM, high-fructose corn syrup, and ethanol
  17. ^ Institute for Agriculture and Trade Policy
  18. ^ Corn Production/Value
  19. ^ The Great Sugar Shaft
  20. ^ James Bovard. "Archer Daniels Midland: A Case Study in Corporate Welfare". cato.org. Retrieved 2007-07-12.
  21. ^ "U.S. per capita food availability – Sugar and sweeteners (individual)". Economic Research Service. 2007-02-15. Retrieved 2007-09-14. {{cite web}}: Check date values in: |date= (help)
  22. ^ WHO Oral Health Country/Area Profile Programme
  23. ^ Template:Ja icon http://sugar.lin.go.jp/japan/data/j_html/j_1_01.htm
  24. ^ High fructose corn syrup: just another sugar? CBC News, November 19, 2008
  25. ^ High fructose corn syrup: just another sugar? CBC News, November 19, 2008
  26. ^ Elliott, Sharon S (2004). "Fructose, weight gain, and the insulin resistance syndrome1". Am J Clin Nutr. 79 (4): 537–43. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)
  27. ^ Soda Warning? New Study Supports Link Between Diabetes, High-fructose Corn Syrup
  28. ^ "Diabetes fears over corn syrup in soda". New Scientist. 04 September 2007. Retrieved 2007-11-17. {{cite web}}: Check date values in: |date= (help)
  29. ^ Theresa Waldron Sugary Sodas High in Diabetes-Linked Compound
  30. ^ Jurgens, Hella (2005). "Consuming Fructose-sweetened Beverages Increases Body Adiposity in Mice" (abstract). Obesity Res. 13: 1146–1156. doi:10.1038/oby.2005.136. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  31. ^ Faeh D, Minehira K, Schwarz JM, Periasamy R, Park S, Tappy L (2005). "Effect of fructose overfeeding and fish oil administration on hepatic de novo lipogenesis and insulin sensitivity in healthy men". DIABETES. 54 (7): 1907–1913. doi:10.2337/diabetes.54.7.1907. PMID 15983189. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  32. ^ Mariniello, J. Martin (2007-11-28). "Weight Loss — Revealing The Hidden Secrets". Obesity Factors In Current Society. Retrieved 2007-11-28.
  33. ^ “Supersize Me” Mice Research Offers Grim Warning for America’s Fast Food Consumers
  34. ^ Forshee; et al. (2007). "A critical examination of the evidence relating high fructose corn syrup and weight gain" (PDF). Critical Reviews in Food Science and Nutrition. 47 (6): 561–582. doi:10.1080/10408390600846457. PMID 17653981. {{cite journal}}: Explicit use of et al. in: |author= (help)
  35. ^ Melanson K et al. Eating Rate and Satiation. Obesity Society (NAASO) 2006 Annual Meeting. October 20-24, 2006, Hynes Convention Center, Boston, Massachusett
  36. ^ The Bitter with the Sweet: the story behind the corn industry's cloying ad blitz
  37. ^ [2]
  38. ^ online abstracts2006 internet forfait haut at eb2006-online.com
  39. ^ Similarities Between HFCS and Sucrose Revealed
  40. ^ Bray, George A. (2004). "Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity". American Journal of Clinical Nutrition. 79 (4): 537–543. PMID 15051594. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)
  41. ^ Warner, Melanie (July 2, 2006). "A Sweetener With a Bad Rap". The New York Times. Retrieved 2007-11-17. {{cite web}}: Check date values in: |date= (help)
  42. ^ Coca-Cola & The American Beverage Ass. to sell the Brooklyn Bridge
  43. ^ American Physiological Society (2008, October 19). Fructose Sets Table For Weight Gain Without Warning. ScienceDaily. Retrieved November 28, 2008
  44. ^ Shapiro et al. Fructose-Induced Leptin Resistance Exacerbates Weight Gain in Response to Subsequent High Fat Feeding. AJP Regulatory Integrative and Comparative Physiology, October, 2008; DOI: 10.1152/ajpregu.00195.2008. Retrieved November 28, 2008
  45. ^ William Campbell Douglass II (2006-06-27). "The new, "all-natural" 7Up soft drink". Retrieved 2007-09-24. {{cite news}}: Check date values in: |date= (help)[unreliable source?]
  46. ^ Howard, Theresa (2006-04-20). "Food, beverage marketers seek healthier images". USAToday. Retrieved 2007-09-24. {{cite news}}: Check date values in: |date= (help)
  47. ^ "CSPI to Sue Cadbury Schweppes over "All Natural" 7UP". Center for Science in the Public Interest. Retrieved 2007-11-17.
  48. ^ Gardner, Steve (January 14, 2007). "CSPI's Litigation Project Forces Change By Two Major Food Companies". Consumer Law and Policy Blog. Retrieved 2007-11-17. {{cite web}}: Check date values in: |date= (help)
  49. ^ "7UP, Now 100% Natural Flavors". Dr Pepper/Seven Up. 2007. Retrieved 2007-09-24.
  50. ^ [3]
  51. ^ [4]
  52. ^ Nature’s Own Honey Wheat
  53. ^ Corn Refiners Association homepage
Retrieved from "https://en.wikipedia.org/w/index.php?title=High-fructose_corn_syrup&oldid=256755038"