Generalized eruptive histiocytoma (also known as "Eruptive histiocytoma,"[1] and "Generalized eruptive histiocytosis"[1]) is a rare cutaneous condition characterized by widespread, erythematous, essentially symmetrical papules, particularly involving the trunk and proximal extremities.[2]: 717
| Generalized eruptive histiocytoma | |
|---|---|
| Other names | Generalized eruptive histiocytosis |
| Specialty | Dermatology |
Signs and symptoms
editGeneralized eruptive histiocytoma is a benign, uncommon kind of histiocytosis caused by non-Langerhans cells that is characterized by symmetrically distributed, brownish or reddish grouped papules on the face, trunk, and proximal extremities. These papules often develop into flares. On the mucous membranes, the lesions are rarely visible. They often go away on their own and may regress leaving behind some hyperchromic macules.[3]
Diagnosis
editHistological analysis reveals a monomorphous, devoid of foamy and giant cells, histiocytic infiltrate in the upper and mid-dermis. Studies using histochemistry and histoenzymatic analysis reveal lysosomal enzyme positivity but no intracellular buildup of fat, mucopolysaccharides, glycogen, or iron. Histiocytic cells have cytoplasmic laminated bodies but lack Birbeck granules, according to electron microscopy studies.[4]
See also
editReferences
edit- ^ a b Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
- ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 978-0-7216-2921-6.
- ^ Cardoso, Fernanda; Serafini, Natália Battisti; Reis, Brisa Dondoni; Nuñez, Mónica Daniela Gauto; Nery, José Augusto da Costa; Lupi, Omar (2013). "Generalized eruptive histiocytoma: a rare disease in an elderly patient*". Anais Brasileiros de Dermatologia. 88 (1). FapUNIFESP (SciELO): 105–108. doi:10.1590/s0365-05962013000100015. ISSN 0365-0596. PMC 3699943. PMID 23539013.
- ^ Gupta, Sanjeev; Aggarwal, Kamal; Jain, VijayKumar; Sen, Rajeev; Gupta, Sunita (2010). "Generalized eruptive histiocytoma". Indian Dermatology Online Journal. 1 (1). Medknow: 27–29. doi:10.4103/2229-5178.73255. ISSN 2229-5178. PMC 3481406. PMID 23130189.
Further reading
edit- Wee, Seong Ho; Kim, Hee Sung; Chang, Sung-Nam; Kim, Dong-Kun; Park, Wook-Hwa (2000). "Generalized Eruptive Histiocytoma: A Pediatric Case". Pediatric Dermatology. 17 (6). Wiley: 453–455. doi:10.1046/j.1525-1470.2000.01842.x. ISSN 0736-8046. PMID 11123777. S2CID 31977709.
- Kwinter, Jennifer; DeKoven, Joel (2009). "Generalized Eruptive Histiocytoma Treated with Isotretinoin". Journal of Cutaneous Medicine and Surgery. 13 (3). SAGE Publications: 146–150. doi:10.2310/7750.2008.07091. ISSN 1203-4754. PMID 19426623. S2CID 19730757.