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{{Short description|Protein-coding gene in the species Homo sapiens}}
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{{PBB|geneid=2962}}
{{Infobox_gene}}
'''General transcription factor IIF, polypeptide 1, 74kDa''', also known as '''GTF2F1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2962| accessdate = }}</ref>
'''General transcription factor IIF subunit 1''' is a [[protein]] that in humans is encoded by the ''GTF2F1'' [[gene]].<ref name="pmid1734284">{{cite journal | vauthors = Finkelstein A, Kostrub CF, Li J, Chavez DP, Wang BQ, Fang SM, Greenblatt J, Burton ZF | title = A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II | journal = Nature | volume = 355 | issue = 6359 | pages = 464–7 | date = March 1992 | pmid = 1734284 | doi = 10.1038/355464a0 | bibcode = 1992Natur.355..464F | s2cid = 1241044 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2962}}</ref>


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== Interactions ==
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
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GTF2F1 has been shown to [[Protein-protein interaction|interact]] with:
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==Interactions==
{{div col|colwidth=20em}}
GTF2F1 has been shown to [[Protein-protein_interaction|interact]] with [[TAF1]],<ref name=pmid8625415>{{cite journal | quotes = yes |last=Dikstein |first=R |authorlink= |coauthors=Ruppert S, Tjian R |year=[[1996]]|month=Mar. |title=TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74 |journal=Cell |volume=84 |issue=5 |pages=781-90 |publisher= |location = UNITED STATES| issn = 0092-8674| pmid = 8625415 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid7590250>{{cite journal | quotes = yes |last=Ruppert |first=S |authorlink= |coauthors=Tjian R |year=[[1995]]|month=Nov. |title=Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation |journal=Genes Dev. |volume=9 |issue=22 |pages=2747-55 |publisher= |location = UNITED STATES| issn = 0890-9369| pmid = 7590250 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid9858607>{{cite journal | quotes = yes |last=Siegert |first=J L |authorlink= |coauthors=Robbins P D |year=[[1999]]|month=Jan. |title=Rb inhibits the intrinsic kinase activity of TATA-binding protein-associated factor TAFII250 |journal=Mol. Cell. Biol. |volume=19 |issue=1 |pages=846-54 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 9858607 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid9482861>{{cite journal | quotes = yes |last=Malik |first=S |authorlink= |coauthors=Guermah M, Roeder R G |year=[[1998]]|month=Mar. |title=A dynamic model for PC4 coactivator function in RNA polymerase II transcription |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=95 |issue=5 |pages=2192-7 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 9482861 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[HNRPU]],<ref name=pmid10490622>{{cite journal | quotes = yes |last=Kim |first=M K |authorlink= |coauthors=Nikodem V M |year=[[1999]]|month=Oct. |title=hnRNP U inhibits carboxy-terminal domain phosphorylation by TFIIH and represses RNA polymerase II elongation |journal=Mol. Cell. Biol. |volume=19 |issue=10 |pages=6833-44 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 10490622 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[GTF2H4]],<ref name=pmid9159119>{{cite journal | quotes = yes |last=Scully |first=R |authorlink= |coauthors=Anderson S F, Chao D M, Wei W, Ye L, Young R A, Livingston D M, Parvin J D |year=[[1997]]|month=May. |title=BRCA1 is a component of the RNA polymerase II holoenzyme |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=94 |issue=11 |pages=5605-10 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 9159119 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[CTDP1]],<ref name=pmid9765293>{{cite journal | quotes = yes |last=Archambault |first=J |authorlink= |coauthors=Pan G, Dahmus G K, Cartier M, Marshall N, Zhang S, Dahmus M E, Greenblatt J |year=[[1998]]|month=Oct. |title=FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO |journal=J. Biol. Chem. |volume=273 |issue=42 |pages=27593-601 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9765293 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[TATA binding protein]],<ref name=pmid9159119/><ref name=pmid7590250/><ref name=pmid9482861/> [[POLR2A]],<ref name=pmid9159119/><ref name=pmid9710619>{{cite journal | quotes = yes |last=Cho |first=H |authorlink= |coauthors=Orphanides G, Sun X, Yang X J, Ogryzko V, Lees E, Nakatani Y, Reinberg D |year=[[1998]]|month=Sep. |title=A human RNA polymerase II complex containing factors that modify chromatin structure |journal=Mol. Cell. Biol. |volume=18 |issue=9 |pages=5355-63 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 9710619 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[MED21]],<ref name=pmid9159119/><ref name=pmid9315662>{{cite journal | quotes = yes |last=Suñé |first=C |authorlink= |coauthors=Hayashi T, Liu Y, Lane W S, Young R A, Garcia-Blanco M A |year=[[1997]]|month=Oct. |title=CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription |journal=Mol. Cell. Biol. |volume=17 |issue=10 |pages=6029-39 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 9315662 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[TAF11]],<ref name=pmid9159119/> [[Serum response factor]]<ref name=pmid7854423>{{cite journal | quotes = yes |last=Joliot |first=V |authorlink= |coauthors=Demma M, Prywes R |year=[[1995]]|month=Feb. |title=Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor |journal=[[Nature (journal)|Nature]] |volume=373 |issue=6515 |pages=632-5 |publisher= |location = ENGLAND| issn = 0028-0836| pmid = 7854423 |doi = 10.1038/373632a0 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid8106390>{{cite journal | quotes = yes |last=Zhu |first=H |authorlink= |coauthors=Joliot V, Prywes R |year=[[1994]]|month=Feb. |title=Role of transcription factor TFIIF in serum response factor-activated transcription |journal=J. Biol. Chem. |volume=269 |issue=5 |pages=3489-97 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 8106390 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[Transcription Factor II B]].<ref name=pmid9159119/><ref name=pmid8662660>{{cite journal | quotes = yes |last=Fang |first=S M |authorlink= |coauthors=Burton Z F |year=[[1996]]|month=May. |title=RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding |journal=J. Biol. Chem. |volume=271 |issue=20 |pages=11703-9 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 8662660 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>
* [[CTDP1]],<ref name = pmid9765293>{{cite journal | vauthors = Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J | title = FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO | journal = J. Biol. Chem. | volume = 273 | issue = 42 | pages = 27593–601 | date = October 1998 | pmid = 9765293 | doi = 10.1074/jbc.273.42.27593| doi-access = free }}</ref>
* [[GTF2H4]],<ref name = pmid9159119>{{cite journal | vauthors = Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD | title = BRCA1 is a component of the RNA polymerase II holoenzyme | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 11 | pages = 5605–10 | date = May 1997 | pmid = 9159119 | pmc = 20825 | doi = 10.1073/pnas.94.11.5605| bibcode = 1997PNAS...94.5605S | doi-access = free }}</ref>
* [[HNRPU]],<ref name = pmid10490622>{{cite journal | vauthors = Kim MK, Nikodem VM | title = hnRNP U inhibits carboxy-terminal domain phosphorylation by TFIIH and represses RNA polymerase II elongation | journal = Mol. Cell. Biol. | volume = 19 | issue = 10 | pages = 6833–44 | date = October 1999 | pmid = 10490622 | pmc = 84680 | doi = 10.1128/MCB.19.10.6833}}</ref>
* [[MED21]],<ref name = pmid9159119/><ref name = pmid9315662>{{cite journal | vauthors = Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA | title = CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription | journal = Mol. Cell. Biol. | volume = 17 | issue = 10 | pages = 6029–39 | date = October 1997 | pmid = 9315662 | pmc = 232452 | doi = 10.1128/MCB.17.10.6029}}</ref>
* [[POLR2A]],<ref name = pmid9159119/><ref name = pmid9710619>{{cite journal | vauthors = Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, Lees E, Nakatani Y, Reinberg D | title = A human RNA polymerase II complex containing factors that modify chromatin structure | journal = Mol. Cell. Biol. | volume = 18 | issue = 9 | pages = 5355–63 | date = September 1998 | pmid = 9710619 | pmc = 109120 | doi = 10.1128/MCB.18.9.5355}}</ref>
* [[Serum response factor]]<ref name = pmid7854423>{{cite journal | vauthors = Joliot V, Demma M, Prywes R | title = Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor | journal = Nature | volume = 373 | issue = 6515 | pages = 632–5 | date = February 1995 | pmid = 7854423 | doi = 10.1038/373632a0 | bibcode = 1995Natur.373..632J | s2cid = 47196160 }}</ref><ref name = pmid8106390>{{cite journal | vauthors = Zhu H, Joliot V, Prywes R | title = Role of transcription factor TFIIF in serum response factor-activated transcription | journal = J. Biol. Chem. | volume = 269 | issue = 5 | pages = 3489–97 | date = February 1994 | doi = 10.1016/S0021-9258(17)41889-8 | pmid = 8106390 | doi-access = free }}</ref>
* [[TAF11]],<ref name = pmid9159119/>
* [[TAF1]],<ref name = pmid8625415>{{cite journal | vauthors = Dikstein R, Ruppert S, Tjian R | title = TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74 | journal = Cell | volume = 84 | issue = 5 | pages = 781–90 | date = March 1996 | pmid = 8625415 | doi = 10.1016/s0092-8674(00)81055-7| s2cid = 18490534 | doi-access = free }}</ref><ref name = pmid7590250>{{cite journal | vauthors = Ruppert S, Tjian R | title = Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation | journal = Genes Dev. | volume = 9 | issue = 22 | pages = 2747–55 | date = November 1995 | pmid = 7590250 | doi = 10.1101/gad.9.22.2747| doi-access = free }}</ref><ref name = pmid9858607>{{cite journal | vauthors = Siegert JL, Robbins PD | title = Rb inhibits the intrinsic kinase activity of TATA-binding protein-associated factor TAFII250 | journal = Mol. Cell. Biol. | volume = 19 | issue = 1 | pages = 846–54 | date = January 1999 | pmid = 9858607 | pmc = 83941 | doi = 10.1128/MCB.19.1.846}}</ref><ref name = pmid9482861>{{cite journal | vauthors = Malik S, Guermah M, Roeder RG | title = A dynamic model for PC4 coactivator function in RNA polymerase II transcription | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 5 | pages = 2192–7 | date = March 1998 | pmid = 9482861 | pmc = 19292 | doi = 10.1073/pnas.95.5.2192| bibcode = 1998PNAS...95.2192M | doi-access = free }}</ref>
* [[TATA binding protein]],<ref name = pmid9159119/><ref name = pmid7590250/><ref name = pmid9482861/> and
* [[Transcription Factor II B]].<ref name = pmid9159119/><ref name = pmid8662660>{{cite journal | vauthors = Fang SM, Burton ZF | title = RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding | journal = J. Biol. Chem. | volume = 271 | issue = 20 | pages = 11703–9 | date = May 1996 | pmid = 8662660 | doi = 10.1074/jbc.271.20.11703| doi-access = free }}</ref>
{{Div col end}}


==See also==
== See also ==
* [[Transcription Factor II F]]
* [[Transcription factor II F]]


==References==
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
* {{cite journal | vauthors = Kato H, Sumimoto H, Pognonec P, Chen CH, Rosen CA, Roeder RG | title = HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors | journal = Genes Dev. | volume = 6 | issue = 4 | pages = 655–66 | year = 1992 | pmid = 1559613 | doi = 10.1101/gad.6.4.655 | doi-access = free }}
{{PBB_Further_reading
* {{cite journal | vauthors = Aso T, Vasavada HA, Kawaguchi T, Germino FJ, Ganguly S, Kitajima S, Weissman SM, Yasukochi Y | title = Characterization of cDNA for the large subunit of the transcription initiation factor TFIIF | journal = Nature | volume = 355 | issue = 6359 | pages = 461–4 | year = 1992 | pmid = 1734283 | doi = 10.1038/355461a0 | bibcode = 1992Natur.355..461A | s2cid = 4312708 }}
| citations =
*{{cite journal | author=Kato H, Sumimoto H, Pognonec P, ''et al.'' |title=HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors. |journal=Genes Dev. |volume=6 |issue= 4 |pages= 655–66 |year= 1992 |pmid= 1559613 |doi=10.1101/gad.6.4.655 }}
* {{cite journal | vauthors = Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O | title = Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence | journal = Nature | volume = 377 | issue = 6547 Suppl | pages = 3–174 | year = 1995 | pmid = 7566098 }}
*{{cite journal | author=Aso T, Vasavada HA, Kawaguchi T, ''et al.'' |title=Characterization of cDNA for the large subunit of the transcription initiation factor TFIIF. |journal=Nature |volume=355 |issue= 6359 |pages= 461–4 |year= 1992 |pmid= 1734283 |doi= 10.1038/355461a0 }}
* {{cite journal | vauthors = Ruppert S, Tjian R | title = Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation | journal = Genes Dev. | volume = 9 | issue = 22 | pages = 2747–55 | year = 1995 | pmid = 7590250 | doi = 10.1101/gad.9.22.2747 | doi-access = free }}
*{{cite journal | author=Finkelstein A, Kostrub CF, Li J, ''et al.'' |title=A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II. |journal=Nature |volume=355 |issue= 6359 |pages= 464–7 |year= 1992 |pmid= 1734284 |doi= 10.1038/355464a0 }}
* {{cite journal | vauthors = Hisatake K, Ohta T, Takada R, Guermah M, Horikoshi M, Nakatani Y, Roeder RG | title = Evolutionary conservation of human TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 92 | issue = 18 | pages = 8195–9 | year = 1995 | pmid = 7667268 | pmc = 41123 | doi = 10.1073/pnas.92.18.8195 | bibcode = 1995PNAS...92.8195H | doi-access = free }}
*{{cite journal | author=Adams MD, Kerlavage AR, Fleischmann RD, ''et al.'' |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3–174 |year= 1995 |pmid= 7566098 |doi=10.1038/377003b0 }}
* {{cite journal | vauthors = Joliot V, Demma M, Prywes R | title = Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor | journal = Nature | volume = 373 | issue = 6515 | pages = 632–5 | year = 1995 | pmid = 7854423 | doi = 10.1038/373632a0 | bibcode = 1995Natur.373..632J | s2cid = 47196160 }}
*{{cite journal | author=Ruppert S, Tjian R |title=Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation. |journal=Genes Dev. |volume=9 |issue= 22 |pages= 2747–55 |year= 1995 |pmid= 7590250 |doi=10.1101/gad.9.22.2747 }}
* {{cite journal | vauthors = Zhu H, Joliot V, Prywes R | title = Role of transcription factor TFIIF in serum response factor-activated transcription | journal = J. Biol. Chem. | volume = 269 | issue = 5 | pages = 3489–97 | year = 1994 | doi = 10.1016/S0021-9258(17)41889-8 | pmid = 8106390 | doi-access = free }}
*{{cite journal | author=Hisatake K, Ohta T, Takada R, ''et al.'' |title=Evolutionary conservation of human TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 18 |pages= 8195–9 |year= 1995 |pmid= 7667268 |doi=10.1073/pnas.92.18.8195 }}
* {{cite journal | vauthors = Yonaha M, Aso T, Kobayashi Y, Vasavada H, Yasukochi Y, Weissman SM, Kitajima S | title = Domain structure of a human general transcription initiation factor, TFIIF | journal = Nucleic Acids Res. | volume = 21 | issue = 2 | pages = 273–9 | year = 1993 | pmid = 8441635 | pmc = 309103 | doi = 10.1093/nar/21.2.273 }}
*{{cite journal | author=Joliot V, Demma M, Prywes R |title=Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor. |journal=Nature |volume=373 |issue= 6515 |pages= 632–5 |year= 1995 |pmid= 7854423 |doi= 10.1038/373632a0 }}
* {{cite journal | vauthors = Aso T, Tsai P, Kawaguchi T, Menninger JC, Kitajima S, Yasukochi Y, Ward DC, Weissman SM | title = Assignment of the human GTF2F1 gene to chromosome 19p13.3 | journal = Genomics | volume = 16 | issue = 1 | pages = 252–3 | year = 1993 | pmid = 8486367 | doi = 10.1006/geno.1993.1168 | doi-access = free }}
*{{cite journal | author=Zhu H, Joliot V, Prywes R |title=Role of transcription factor TFIIF in serum response factor-activated transcription. |journal=J. Biol. Chem. |volume=269 |issue= 5 |pages= 3489–97 |year= 1994 |pmid= 8106390 |doi= }}
* {{cite journal | vauthors = Dikstein R, Ruppert S, Tjian R | title = TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74 | journal = Cell | volume = 84 | issue = 5 | pages = 781–90 | year = 1996 | pmid = 8625415 | doi = 10.1016/S0092-8674(00)81055-7 | s2cid = 18490534 | doi-access = free }}
*{{cite journal | author=Yonaha M, Aso T, Kobayashi Y, ''et al.'' |title=Domain structure of a human general transcription initiation factor, TFIIF. |journal=Nucleic Acids Res. |volume=21 |issue= 2 |pages= 273–9 |year= 1993 |pmid= 8441635 |doi=10.1093/nar/21.2.273 }}
* {{cite journal | vauthors = Fang SM, Burton ZF | title = RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding | journal = J. Biol. Chem. | volume = 271 | issue = 20 | pages = 11703–9 | year = 1996 | pmid = 8662660 | doi = 10.1074/jbc.271.20.11703 | doi-access = free }}
*{{cite journal | author=Aso T, Tsai P, Kawaguchi T, ''et al.'' |title=Assignment of the human GTF2F1 gene to chromosome 19p13.3. |journal=Genomics |volume=16 |issue= 1 |pages= 252–3 |year= 1993 |pmid= 8486367 |doi= 10.1006/geno.1993.1168 }}
* {{cite journal | vauthors = McEwan IJ, Dahlman-Wright K, Ford J, Wright AP | title = Functional interaction of the c-Myc transactivation domain with the TATA binding protein: evidence for an induced fit model of transactivation domain folding | journal = Biochemistry | volume = 35 | issue = 29 | pages = 9584–93 | year = 1996 | pmid = 8755740 | doi = 10.1021/bi960793v }}
*{{cite journal | author=Dikstein R, Ruppert S, Tjian R |title=TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74. |journal=Cell |volume=84 |issue= 5 |pages= 781–90 |year= 1996 |pmid= 8625415 |doi=10.1016/S0092-8674(00)81055-7 }}
* {{cite journal | vauthors = Zhou Q, Sharp PA | title = Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat | journal = Science | volume = 274 | issue = 5287 | pages = 605–10 | year = 1996 | pmid = 8849451 | doi = 10.1126/science.274.5287.605 | bibcode = 1996Sci...274..605Z | s2cid = 13266489 }}
*{{cite journal | author=Fang SM, Burton ZF |title=RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding. |journal=J. Biol. Chem. |volume=271 |issue= 20 |pages= 11703–9 |year= 1996 |pmid= 8662660 |doi=10.1074/jbc.271.20.11703 }}
* {{cite journal | vauthors = Parada CA, Roeder RG | title = Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain | journal = Nature | volume = 384 | issue = 6607 | pages = 375–8 | year = 1996 | pmid = 8934526 | doi = 10.1038/384375a0 | bibcode = 1996Natur.384..375P | s2cid = 4278432 }}
*{{cite journal | author=McEwan IJ, Dahlman-Wright K, Ford J, Wright AP |title=Functional interaction of the c-Myc transactivation domain with the TATA binding protein: evidence for an induced fit model of transactivation domain folding. |journal=Biochemistry |volume=35 |issue= 29 |pages= 9584–93 |year= 1996 |pmid= 8755740 |doi= 10.1021/bi960793v }}
* {{cite journal | vauthors = Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM | title = The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme | journal = Mol. Cell. Biol. | volume = 17 | issue = 4 | pages = 1817–23 | year = 1997 | pmid = 9121429 | pmc = 232028 | doi = 10.1128/mcb.17.4.1817}}
*{{cite journal | author=Zhou Q, Sharp PA |title=Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat. |journal=Science |volume=274 |issue= 5287 |pages= 605–10 |year= 1996 |pmid= 8849451 |doi=10.1126/science.274.5287.605 }}
* {{cite journal | vauthors = Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD | title = BRCA1 is a component of the RNA polymerase II holoenzyme | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 11 | pages = 5605–10 | year = 1997 | pmid = 9159119 | pmc = 20825 | doi = 10.1073/pnas.94.11.5605 | bibcode = 1997PNAS...94.5605S | doi-access = free }}
*{{cite journal | author=Parada CA, Roeder RG |title=Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain. |journal=Nature |volume=384 |issue= 6607 |pages= 375–8 |year= 1996 |pmid= 8934526 |doi= 10.1038/384375a0 }}
* {{cite journal | vauthors = McEwan IJ, Gustafsson J | title = Interaction of the human androgen receptor transactivation function with the general transcription factor TFIIF | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 16 | pages = 8485–90 | year = 1997 | pmid = 9238003 | pmc = 22967 | doi = 10.1073/pnas.94.16.8485 | bibcode = 1997PNAS...94.8485M | doi-access = free }}
*{{cite journal | author=Cujec TP, Cho H, Maldonado E, ''et al.'' |title=The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme. |journal=Mol. Cell. Biol. |volume=17 |issue= 4 |pages= 1817–23 |year= 1997 |pmid= 9121429 |doi= }}
* {{cite journal | vauthors = Newberry EP, Latifi T, Battaile JT, Towler DA | title = Structure-function analysis of Msx2-mediated transcriptional suppression | journal = Biochemistry | volume = 36 | issue = 34 | pages = 10451–62 | year = 1997 | pmid = 9265625 | doi = 10.1021/bi971008x }}
*{{cite journal | author=Scully R, Anderson SF, Chao DM, ''et al.'' |title=BRCA1 is a component of the RNA polymerase II holoenzyme. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 11 |pages= 5605–10 |year= 1997 |pmid= 9159119 |doi=10.1073/pnas.94.11.5605 }}
* {{cite journal | vauthors = O'Brien T, Tjian R | title = Functional analysis of the human TAFII250 N-terminal kinase domain | journal = Mol. Cell | volume = 1 | issue = 6 | pages = 905–11 | year = 1998 | pmid = 9660973 | doi = 10.1016/S1097-2765(00)80089-1 | doi-access = free }}
*{{cite journal | author=McEwan IJ, Gustafsson J |title=Interaction of the human androgen receptor transactivation function with the general transcription factor TFIIF. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 16 |pages= 8485–90 |year= 1997 |pmid= 9238003 |doi=10.1073/pnas.94.16.8485 }}
*{{cite journal | author=Newberry EP, Latifi T, Battaile JT, Towler DA |title=Structure-function analysis of Msx2-mediated transcriptional suppression. |journal=Biochemistry |volume=36 |issue= 34 |pages= 10451–62 |year= 1997 |pmid= 9265625 |doi= 10.1021/bi971008x }}
*{{cite journal | author=O'Brien T, Tjian R |title=Functional analysis of the human TAFII250 N-terminal kinase domain. |journal=Mol. Cell |volume=1 |issue= 6 |pages= 905–11 |year= 1998 |pmid= 9660973 |doi=10.1016/S1097-2765(00)80089-1 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|GTF2F1+protein,+human}}
* {{MeshName|GTF2F1+protein,+human}}
* {{FactorBook|GTF2F1}}


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{{PDB Gallery|geneid=2962}}
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{{Transcription factors|g2}}
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{{NLM content}}


{{gene-19-stub}}
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{{NLM content}}
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{{Transcription factors|g2}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]

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Latest revision as of 14:40, 29 January 2023

GTF2F1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGTF2F1, general transcription factor IIF, polypeptide 1, 74kDa, BTF4, RAP74, TF2F1, TFIIF, general transcription factor IIF subunit 1
External IDsOMIM: 189968; MGI: 1923848; HomoloGene: 1585; GeneCards: GTF2F1; OMA:GTF2F1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

2962

98053

Ensembl

ENSG00000125651

ENSMUSG00000002658

UniProt

P35269

Q3THK3

RefSeq (mRNA)

NM_002096

NM_133801

RefSeq (protein)

NP_002087

NP_598562

Location (UCSC)Chr 19: 6.38 – 6.39 MbChr 17: 57.31 – 57.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

General transcription factor IIF subunit 1 is a protein that in humans is encoded by the GTF2F1 gene.[5][6]

Interactions

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GTF2F1 has been shown to interact with:

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125651 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002658 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Finkelstein A, Kostrub CF, Li J, Chavez DP, Wang BQ, Fang SM, Greenblatt J, Burton ZF (March 1992). "A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II". Nature. 355 (6359): 464–7. Bibcode:1992Natur.355..464F. doi:10.1038/355464a0. PMID 1734284. S2CID 1241044.
  6. ^ "Entrez Gene: GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa".
  7. ^ Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J (October 1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO". J. Biol. Chem. 273 (42): 27593–601. doi:10.1074/jbc.273.42.27593. PMID 9765293.
  8. ^ a b c d e f Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. Bibcode:1997PNAS...94.5605S. doi:10.1073/pnas.94.11.5605. PMC 20825. PMID 9159119.
  9. ^ Kim MK, Nikodem VM (October 1999). "hnRNP U inhibits carboxy-terminal domain phosphorylation by TFIIH and represses RNA polymerase II elongation". Mol. Cell. Biol. 19 (10): 6833–44. doi:10.1128/MCB.19.10.6833. PMC 84680. PMID 10490622.
  10. ^ Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA (October 1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Mol. Cell. Biol. 17 (10): 6029–39. doi:10.1128/MCB.17.10.6029. PMC 232452. PMID 9315662.
  11. ^ Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, Lees E, Nakatani Y, Reinberg D (September 1998). "A human RNA polymerase II complex containing factors that modify chromatin structure". Mol. Cell. Biol. 18 (9): 5355–63. doi:10.1128/MCB.18.9.5355. PMC 109120. PMID 9710619.
  12. ^ Joliot V, Demma M, Prywes R (February 1995). "Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor". Nature. 373 (6515): 632–5. Bibcode:1995Natur.373..632J. doi:10.1038/373632a0. PMID 7854423. S2CID 47196160.
  13. ^ Zhu H, Joliot V, Prywes R (February 1994). "Role of transcription factor TFIIF in serum response factor-activated transcription". J. Biol. Chem. 269 (5): 3489–97. doi:10.1016/S0021-9258(17)41889-8. PMID 8106390.
  14. ^ Dikstein R, Ruppert S, Tjian R (March 1996). "TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74". Cell. 84 (5): 781–90. doi:10.1016/s0092-8674(00)81055-7. PMID 8625415. S2CID 18490534.
  15. ^ a b Ruppert S, Tjian R (November 1995). "Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation". Genes Dev. 9 (22): 2747–55. doi:10.1101/gad.9.22.2747. PMID 7590250.
  16. ^ Siegert JL, Robbins PD (January 1999). "Rb inhibits the intrinsic kinase activity of TATA-binding protein-associated factor TAFII250". Mol. Cell. Biol. 19 (1): 846–54. doi:10.1128/MCB.19.1.846. PMC 83941. PMID 9858607.
  17. ^ a b Malik S, Guermah M, Roeder RG (March 1998). "A dynamic model for PC4 coactivator function in RNA polymerase II transcription". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2192–7. Bibcode:1998PNAS...95.2192M. doi:10.1073/pnas.95.5.2192. PMC 19292. PMID 9482861.
  18. ^ Fang SM, Burton ZF (May 1996). "RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding". J. Biol. Chem. 271 (20): 11703–9. doi:10.1074/jbc.271.20.11703. PMID 8662660.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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