Rose bengal: Difference between revisions
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A form of Rose Bengal is also being studied as a treatment for certain cancers. The company, Provectus Pharmaceuticals, renamed the drug PV-10 and is currently undergoing clinical trials for melanoma. |
A form of Rose Bengal is also being studied as a treatment for certain cancers. The company, Provectus Pharmaceuticals, renamed the drug PV-10 and is currently undergoing clinical trials for melanoma. |
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== Chemical |
== Chemical applications == |
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Rose Bengal is also used in synthetic chemistry to generate [[singlet oxygen]] from [[triplet oxygen]]. The singlet oxygen can then undergo a variety of useful reactions, particularly [2 + 2] [[Cycloaddition|cycloadditions]] with [[Alkene|alkenes]] and similar systems. |
Rose Bengal is also used in synthetic chemistry to generate [[singlet oxygen]] from [[triplet oxygen]]. The singlet oxygen can then undergo a variety of useful reactions, particularly [2 + 2] [[Cycloaddition|cycloadditions]] with [[Alkene|alkenes]] and similar systems. |
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== Biological |
== Biological applications == |
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Rose Bengal is also used in [[animal models of ischemic stroke]] (photothrombotic stroke models) in biomedical research. A bolus of the compound is injected into the venous system. Then the region of interest, e. g. the cerebral cortex, is exposed and illuminated by LASER light of 561 nm. A thrombus is formed in the illuminated blood vessels, causing a stroke in the dependent brain tissue. |
Rose Bengal is also used in [[animal models of ischemic stroke]] (photothrombotic stroke models) in biomedical research. A bolus of the compound is injected into the venous system. Then the region of interest, e. g. the cerebral cortex, is exposed and illuminated by LASER light of 561 nm. A thrombus is formed in the illuminated blood vessels, causing a stroke in the dependent brain tissue. |
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Revision as of 00:10, 25 May 2008
Rose Bengal (4,5,6,7-tetrachloro-2',4',5',7'-tetraiodofluorescein) is a stain. Its sodium salt is commonly used in eye drops to stain damaged conjunctival and corneal cells and thereby identify damage to the eye.
Absportion and extinction data can be found at: omlc.ogi.edu/spectra/PhotochemCAD/html/rosebengal.html [1]
The stain is also used in the preparation of Foraminifera for microscopic analysis, allowing the distinction between forms that were alive or dead at the time of collection.
A form of Rose Bengal is also being studied as a treatment for certain cancers. The company, Provectus Pharmaceuticals, renamed the drug PV-10 and is currently undergoing clinical trials for melanoma.
Chemical applications
Rose Bengal is also used in synthetic chemistry to generate singlet oxygen from triplet oxygen. The singlet oxygen can then undergo a variety of useful reactions, particularly [2 + 2] cycloadditions with alkenes and similar systems.
Biological applications
Rose Bengal is also used in animal models of ischemic stroke (photothrombotic stroke models) in biomedical research. A bolus of the compound is injected into the venous system. Then the region of interest, e. g. the cerebral cortex, is exposed and illuminated by LASER light of 561 nm. A thrombus is formed in the illuminated blood vessels, causing a stroke in the dependent brain tissue.
External links
- Rose+Bengal at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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