ACKR3: Difference between revisions
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{{PBB|geneid=57007}} |
{{PBB|geneid=57007}} |
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'''C-X-C chemokine receptor type 7''' (CXCR-7) is a [[protein]] that in humans is encoded by the ''CXCR7'' [[gene]].<ref name="pmid16107333">{{cite journal | author = Balabanian K, Lagane B, Infantino S, Chow KY, Harriague J, Moepps B, Arenzana-Seisdedos F, Thelen M, Bachelerie F | title = The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes | journal = J Biol Chem | volume = 280 | issue = 42 | pages = 35760–6 | |
'''C-X-C chemokine receptor type 7''' (CXCR-7) is a [[protein]] that in humans is encoded by the ''CXCR7'' [[gene]].<ref name="pmid16107333">{{cite journal | author = Balabanian K, Lagane B, Infantino S, Chow KY, Harriague J, Moepps B, Arenzana-Seisdedos F, Thelen M, Bachelerie F | title = The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes | journal = J Biol Chem | volume = 280 | issue = 42 | pages = 35760–6 |date=Oct 2005 | pmid = 16107333 | pmc = | doi = 10.1074/jbc.M508234200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CXCR7 chemokine (C-X-C motif) receptor 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57007| accessdate = }}</ref> |
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This gene encodes a member of the [[G protein-coupled receptor]] family. This protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP) and was considered to be an orphan receptor. It is now classified as a [[chemokine receptor]] able to bind the chemokines [[CXCL12]]/SDF-1 and [[CXCL11]]. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. Whereas some reports claim that the receptor induces signaling following ligand binding, recent findings in zebrafish suggest that CXCR7 functions primarily by sequestering the chemokine CXCL12.<ref name="entrez"/> |
This gene encodes a member of the [[G protein-coupled receptor]] family. This protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP) and was considered to be an orphan receptor. It is now classified as a [[chemokine receptor]] able to bind the chemokines [[CXCL12]]/SDF-1 and [[CXCL11]]. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. Whereas some reports claim that the receptor induces signaling following ligand binding, recent findings in zebrafish suggest that CXCR7 functions primarily by sequestering the chemokine CXCL12.<ref name="entrez"/> |
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Revision as of 18:34, 4 February 2014
Template:PBB C-X-C chemokine receptor type 7 (CXCR-7) is a protein that in humans is encoded by the CXCR7 gene.[1][2]
This gene encodes a member of the G protein-coupled receptor family. This protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP) and was considered to be an orphan receptor. It is now classified as a chemokine receptor able to bind the chemokines CXCL12/SDF-1 and CXCL11. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. Whereas some reports claim that the receptor induces signaling following ligand binding, recent findings in zebrafish suggest that CXCR7 functions primarily by sequestering the chemokine CXCL12.[2]
However, another recent study has provided evidence that ligand binding to CXCR7 activates MAP kinases through Beta-arrestins, and thus has functions beyond ligand sequestration.[3]
References
- ^ Balabanian K, Lagane B, Infantino S, Chow KY, Harriague J, Moepps B, Arenzana-Seisdedos F, Thelen M, Bachelerie F (Oct 2005). "The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes". J Biol Chem. 280 (42): 35760–6. doi:10.1074/jbc.M508234200. PMID 16107333.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ a b "Entrez Gene: CXCR7 chemokine (C-X-C motif) receptor 7".
- ^ *Rajagopal, Sudarshan.; et al. (2009). "B-arrestin-but not G protein-mediated signaling by the "decoy" receptor CXCR7". PNAS. 107 (2): 628–632. doi:10.1073/pnas.0912852107. PMC 2818968. PMID 20018651.
{{cite journal}}: Explicit use of et al. in:|author=(help)
Further reading
- Miao Z, Luker KE; et al. (2007). "CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature". PNAS. 104 (40): 15735–15740. doi:10.1073/pnas.0610444104. PMC 1994579. PMID 17898181.
{{cite journal}}: Explicit use of et al. in:|author=(help) - Wang J, Shiozawa Y, Wang J; et al. (2008). "The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer". J Biol Chem. 283 (7): 4283–4294. doi:10.1074/jbc.M707465200. PMID 18057003.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - Boldajipour B, Mahabaleshwar H, Kardash E; et al. (2008). "Control of Chemokine-Guided Cell Migration by Ligand Sequestration". Cell. 132 (3): 463–473. doi:10.1016/j.cell.2007.12.034. PMID 18267076.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link)
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