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[[Category:Hydrolases acting on nonpeptide C-N bonds]]
[[Category:EC 3.5.1]]
[[Category:Genes mutated in mice]]
[[Category:Genes mutated in mice]]

Revision as of 08:22, 16 December 2014

Template:PBB Histone deacetylase 1 is an enzyme that in humans is encoded by the HDAC1 gene.[1]

Template:PBB Summary

Model organisms

Model organisms have been used in the study of HDAC1 function. A conditional knockout mouse line, called Hdac1tm1a(EUCOMM)Wtsi[6][7] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[8][9][10] Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[4][11] Twenty five tests were carried out and two phenotypes were reported. A reduced number of homozygous mutant embryos were identified during gestation, and none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice, and no significant abnormalities were observed in these animals.[4]

See also

Interactions

HDAC1 has been shown to interact with RAD9A,[12] DNMT3L,[13][14] MTA1,[15][16] FKBP3,[17] CDC20,[18] CDH1,[18] Host cell factor C1,[19] BUB3,[18] Nuclear receptor co-repressor 2,[20][21] IKZF1,[22][23] Prohibitin,[24][25] EVI1,[26][27] DDX5,[28] DNMT3A,[29] Mothers against decapentaplegic homolog 2,[30] Histone deacetylase 2,[15][20][31][32][33][34][35][36][37][38][39][40][41] MIER1,[42] SIN3A,[15][37][38][39][43][44][45][46][47][48][49][50][51][52] Death-associated protein 6,[53] Androgen receptor,[54] HMG20B,[31] HUS1,[12] IFRD1,[55] MLL,[56] ING1,[52][57] MyoD,[58][59] GATA1,[60] SPEN,[61] Mad1,[18] Promyelocytic leukemia protein,[62][63] CHD3,[38][52] Homeobox protein TGIF1,[64][65] Retinoblastoma-like protein 2,[66][67] Retinoblastoma-like protein 1,[66][68] CHD4,[15][38][46] RCOR1,[31][48] RBBP7,[15][37][40][69] RFC1,[70] Retinoblastoma protein,[25][58][66][68][71][72][73] RBBP4,[15][37][39][40][43][46][48][49][69][74][75] EED,[41] PHF21A,[31][76] SIN3B,[22][37] RELA,[36][77][78] NFKB1,[78] BUB1B,[18] Mdm2,[79] SATB1,[50] HSPA4,[34] SUV39H1,[80] BUB1,[18] Methyl-CpG-binding domain protein 2,[37][69][81] Zinc finger and BTB domain-containing protein 16,[82][83][84] DDX17,[28] BCL6,[83][85] SUDS3,[44][86] SAP30,[37][52][87][88][89][90] Sp1 transcription factor,[49][91][92][93] MTA2,[15][37][48][50] PCNA,[94] CBFA2T3,[95][96] TOP2B,[97][98] MBD3,[37][99][100] CTBP1,[64][101][102] TOP2A,[97][98] EZH2,[41]BTG2,[103] and COUP-TFII.[104]

References

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