CLTB

CLTB
Identifiers
Aliases	CLTB, LCB, clathrin light chain B
External IDs	OMIM: 118970; MGI: 1921575; HomoloGene: 37532; GeneCards: CLTB; OMA:CLTB - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	176,416,539 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	54,759,157 bp
RNA expression pattern
	Top expressed in
	skin of leg; ; skin of abdomen; ; gingival epithelium; ; apex of heart; ; mucosa of transverse colon; ; gastrocnemius muscle; ; right auricle; ; left ventricle; ; right frontal lobe; ; muscle of thigh;
	Top expressed in
	neural layer of retina; ; lip; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; muscle of thigh; ; esophagus; ; primary visual cortex; ; anterior horn of spinal cord; ; skin of external ear;
	More reference expression data
	n/a
Gene ontology
Molecular function	clathrin heavy chain binding; peptide binding; protein binding; structural molecule activity;
Cellular component	ciliary membrane; clathrin-coated pit; clathrin coat of trans-Golgi network vesicle; membrane; cytoplasmic vesicle membrane; cytoplasmic vesicle; clathrin coat of coated pit; intracellular membrane-bounded organelle; trans-Golgi network; clathrin vesicle coat; clathrin coat; plasma membrane; cytosol; synaptic vesicle membrane; clathrin-coated endocytic vesicle; presynaptic endocytic zone membrane; postsynaptic endocytic zone cytoplasmic component;
Biological process	clathrin-dependent endocytosis; vesicle-mediated transport; intracellular protein transport; membrane organization; clathrin coat assembly;
	Sources:Amigo / QuickGO
Orthologs
	1212
	74325
	ENSG00000175416
	ENSMUSG00000047547
	P09497
	Q6IRU5
	NM_001834; NM_007097; NM_001364126; NM_001364127
	NM_028870; NM_001347512
	NP_001825; NP_009028; NP_001351055; NP_001351056; NP_001825.1
	NP_001334441; NP_083146
	Wikidata
View/Edit Human	View/Edit Mouse

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Clathrin, light chain B is a protein in humans that is encoded by the CLTB gene.^[5]

Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and coated vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175416 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047547 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Clathrin, light chain B". Retrieved 2013-06-05.

References

Further reading