FABP6

FABP6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1O1U, 1O1V, 2MM3
Identifiers
Aliases	FABP6, I-15P, I-BABP, I-BALB, I-BAP, ILBP, ILBP3, ILLBP, fatty acid binding protein 6
External IDs	OMIM: 600422; MGI: 96565; HomoloGene: 1108; GeneCards: FABP6; OMA:FABP6 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q33.3 Start 160,187,367 bp End 160,238,735 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 B1.1|11 25.81 cM Start 43,486,876 bp End 43,492,367 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum right uterine tube bronchial epithelial cell olfactory zone of nasal mucosa nucleus accumbens caudate nucleus putamen testicle hypothalamus substantia nigra Top expressed in crypt of lieberkuhn of small intestine Paneth cell ileum intestinal villus conjunctival fornix blastocyst epithelium of small intestine Ileal epithelium esophagus cornea More reference expression data BioGPS More reference expression data
Gene ontology Molecular function bile acid binding lipid binding Cellular component cytoplasm cytosol membrane Biological process lipid metabolism triglyceride catabolic process negative regulation of cell population proliferation lipid transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2172 16204 Ensembl ENSG00000170231 ENSMUSG00000020405 UniProt P51161 P51162 RefSeq (mRNA) NM_001040442 NM_001130958 NM_001445 NM_008375 RefSeq (protein) NP_001035532 NP_001124430 NP_001436 NP_032401 Location (UCSC) Chr 5: 160.19 – 160.24 Mb Chr 11: 43.49 – 43.49 Mb PubMed search
Wikidata
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Fatty acid binding protein 6, ileal (gastrotropin), also known as FABP6, is a protein which in humans is encoded by the FABP6 gene.

Function

This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene.

Further reading

• Börchers T, Hohoff C, Buhlmann C, Spener F (1997). "Heart-type fatty acid binding protein - involvement in growth inhibition and differentiation". Prostaglandins Leukot. Essent. Fatty Acids. 57 (1): 77–84. doi:10.1016/S0952-3278(97)90496-8. PMID 9250612.
• Fujita M, Fujii H, Kanda T, et al. (1995). "Molecular cloning, expression, and characterization of a human intestinal 15-kDa protein". Eur. J. Biochem. 233 (2): 406–413. doi:10.1111/j.1432-1033.1995.406_2.x. PMID 7588781.
• Oelkers P, Dawson PA (1995). "Cloning and chromosomal localization of the human ileal lipid-binding protein". Biochim. Biophys. Acta. 1257 (2): 199–202. doi:10.1016/0005-2760(95)00098-w. PMID 7619861.
• Birkenmeier EH, Rowe LB, Crossman MW, Gordon JI (1995). "Ileal lipid-binding protein (Illbp) gene maps to mouse chromosome 11". Mamm. Genome. 5 (12): 805–806. doi:10.1007/BF00292019. PMID 7894165. S2CID 28184037.
• Watanabe K, Hoshi N, Tsuura Y, et al. (1996). "Immunohistochemical distribution of intestinal 15 kDa protein in human tissues". Arch. Histol. Cytol. 58 (3): 303–306. doi:10.1679/aohc.58.303. PMID 8527237.
• Lücke C, Zhang F, Rüterjans H, et al. (1997). "Flexibility is a likely determinant of binding specificity in the case of ileal lipid binding protein". Structure. 4 (7): 785–800. doi:10.1016/S0969-2126(96)00086-X. PMID 8805562.
• Grober J, Zaghini I, Fujii H, et al. (1999). "Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer". J. Biol. Chem. 274 (42): 29749–29754. doi:10.1074/jbc.274.42.29749. PMID 10514450.
• Seibert C, Harteneck C, Ernst OP, et al. (2000). "Activation of the rod G-protein Gt by the thrombin receptor (PAR1) expressed in Sf9 cells". Eur. J. Biochem. 266 (3): 911–916. doi:10.1046/j.1432-1327.1999.00927.x. PMID 10583385.
• Lücke C, Zhang F, Hamilton JA, et al. (2000). "Solution structure of ileal lipid binding protein in complex with glycocholate". Eur. J. Biochem. 267 (10): 2929–2938. doi:10.1046/j.1432-1327.2000.01307.x. PMID 10806391.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kurz M, Brachvogel V, Matter H, et al. (2003). "Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures". Proteins. 50 (2): 312–328. doi:10.1002/prot.10289. PMID 12486725. S2CID 20185435.
• Barley NF, Taylor V, Shaw-Smith CJ, et al. (2004). "Human ileal bile acid-binding protein promoter and the effects of CDX2". Biochim. Biophys. Acta. 1630 (2–3): 138–143. doi:10.1016/j.bbaexp.2003.09.008. PMID 14654244.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Landrier JF, Thomas C, Grober J, et al. (2005). "The gene encoding the human ileal bile acid-binding protein (I-BABP) is regulated by peroxisome proliferator-activated receptors". Biochim. Biophys. Acta. 1735 (1): 41–49. doi:10.1016/j.bbalip.2005.05.002. PMID 15936983.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Bergheim I, Harsch S, Mueller O, et al. (2006). "Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers". J. Lipid Res. 47 (1): 42–50. doi:10.1194/jlr.M500215-JLR200. PMID 16237211.
• Ohmachi T, Inoue H, Mimori K, et al. (2007). "Fatty acid binding protein 6 is overexpressed in colorectal cancer". Clin. Cancer Res. 12 (17): 5090–5095. doi:10.1158/1078-0432.CCR-05-2045. PMID 16951225.
• Fang C, Dean J, Smith JW (2007). "A novel variant of ileal bile acid binding protein is up-regulated through nuclear factor-kappaB activation in colorectal adenocarcinoma". Cancer Res. 67 (19): 9039–9046. doi:10.1158/0008-5472.CAN-06-3690. PMID 17909007.