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Arthur M. Sackler
Born
Arthur Mitchell Sackler

(1913-08-22)August 22, 1913
New York City, U.S.
DiedMay 26, 1987(1987-05-26) (aged 73)
New York City, U.S.
EducationNew York University (MD)
Spouses
  • Else Finnich Jorgensen
  • Marietta Lutze
  • Jillian Tully
Children4, including Elizabeth
Relatives
FamilySackler

Arthur Mitchell Sackler (August 22, 1913 – May 26, 1987) was an American psychiatrist and marketer of pharmaceuticals whose fortune originated in medical advertising and trade publications. He was also an art collector.[1][2] He was one of the three patriarchs of the controversial Sackler family pharmaceutical dynasty.

Sackler amassed the largest personal Chinese art collection in the world, which he donated to the Smithsonian. He provided the funds needed to build numerous art galleries and schools of medicine. Sackler's estate was estimated at $140 million.[3]

Since his death, Sackler's reputation has been tarnished due to his company Purdue Pharma's central role in the opioid crisis. Many of the museums and galleries that Sackler donated to have distanced themselves from him and his family in the wake of the opioid crisis and the Sackler family's resulting reputational fall. On December 9, 2021, the Metropolitan Museum of Art in New York City officially removed the Sackler family name from galleries which had been named after them.[4]

Early life and education

[edit]

Born Abraham Sackler in Brooklyn to Isaac and Sophie (née Greenberg) Sackler, Jewish grocers who came to New York from Ukraine and Poland before World War I, Sackler was the eldest of three sons.[5][6][7] Sackler graduated from Erasmus Hall High School.[8] In The New Yorker, Patrick Radden Keefe called him a polymath for his varied interests.[9] He attended New York University School of Medicine and graduated with an M.D.[10] Sackler paid his tuition by working as a copywriter in 1942 at William Douglas McAdams, an ad agency specializing in medicine, a company that he would buy in 1947 and revolutionize.[9][10] He also studied sculpture at the Educational Alliance and art history classes at Cooper Union.[11]

Psychiatry

[edit]

Sackler completed his residency in psychiatry at the Creedmoor Psychiatric Center. From 1949 to 1954, he was director of research at Creedmoor Institute for Psychobiological Studies. He specialized in biological psychiatry.[11][12] Sackler collaborated on hundreds of papers based on neuroendocrinology, psychiatry, and experimental medicine.[13] He was said to be the first physician to use ultrasound as a diagnostic tool.[12] All three brothers studied in Scotland,[14] became psychiatrists, and joined the research staff at Creedmoor. They had a friend and collaborator, director Johan H. W. Van Ophuijsen, who was described by Arthur Sackler as "Freud's favorite disciple."[9]

In 1951, the three brothers and Van Ophuijsen published a summary of their work,[15] which became known as the "Sackler method."[16] Human subject research, which was stopped for the most part after World War II, did not yet have the oversight of the Nuremberg Code and later the Declaration of Helsinki and the Belmont Report.[17] The Sacklers sought to find a substitute for what could be relatively intrusive electroconvulsive therapy (ECT). They treated with histamine persons who had schizophrenia, persons who had bipolar disorder then termed manic depression, and persons with involutional psychosis, now an unrecognized illness somewhat like depression.[15] Patients were given injections of histamine of increasing strength for up to 24 days.[15] The treatment caused their blood pressure to drop; when their blood pressure recovered, they were given a stronger dose, until blood pressure reached 60/0 mm Hg.[15] Some patients received combination treatments of histamine coupled with insulin or ECT.[15]

Art collection

[edit]

Sackler and his wife Else began collecting art in the 1940s, shortly after his graduation from NYU. Initially they were attracted to contemporary artists like Marc Chagall but later also collected Renaissance majolica and Post-Impressionist and School of Paris paintings.[18] He considered himself "more of a curator than collector" who preferred acquiring collections to individual pieces. His collection was composed of tens of thousands of works including Chinese, Indian, and Middle Eastern art as well as Renaissance and pre-Columbian pieces.[1] In a speech at Stony Brook University in New York, he discussed his idea that art and science were "interlinked in the humanities".[19]

A small Chinese table in a New York furniture dealer put Chinese art into focus for Sackler who thought, "that here was an esthetic not commonly appreciated or understood." Following the Chinese Civil War, exporters cashed out their holdings and young collectors like Sackler were fortunate to be good targets. He amassed tens of thousands of objects in his life, representing wide and varied interests—Shang dynasty oracle bones, Achaemenid vessels from Iran, and South Asian temple sculpture from the tenth to fourteenth century. Some works are of exhibition quality and some are more appropriate for studies.[18][20]

He later gave money quarterly to psychiatrist Paul Singer, another enthusiastic collector of Chinese works, who did not have funds but whose taste Sackler trusted. The one string attached to the gift was that upon Singer's death, his collection would be given to a Sackler gallery. In 1997, while cataloguing the collection for acquisition, the Smithsonian museum staff determined that 160 documented objects were missing from Dr. Singer's residence at the time of his death. Most of the lost collection has not been recovered to this day.[21][20]

Marketing

[edit]
Main article: Pharmaceutical marketing

In the early 1940s he joined medical advertising agency William Douglas McAdams Inc.,[22] where he remained active until his death.[23] Sackler transformed the agency with sales techniques hitherto unknown to pharmaceutical manufacturers. A Harvard University historian wrote in 2019 that the Sacklers did not invent direct sales to physicians but they were a pioneering influence. Arthur Sackler marketed in publications targeting physicians directly which increased the pace at which doctors learned about medicines and brought them to market, but did not ever participate in sales force canvassing and detailing, a technique now under tremendous scrutiny.[24]

The Medical Advertising Hall of Fame wrote in 1998,

"No single individual did more to shape the character of medical advertising than the multi-talented Dr. Arthur Sackler. His seminal contribution was bringing the full power of advertising and promotion to pharmaceutical marketing."[24]

With Sackler's help, the pharmaceutical giant Pfizer, previously a chemical manufacturer, began its business in prescription drugs.[25] In 1950, Pfizer had 8 salesmen and expanded that force to 2000 in 1957.[24] Between 1950 and 1956, with Sackler's guidance, Pfizer competed in the new antibiotic marketplace with Terramycin.[24]

Through direct marketing to physicians during the 1960s, he popularized dozens of medicines including Betadine, Senaflax, Librium, and Valium. He became a publisher and started a weekly medical newspaper in 1960, the Medical Tribune, which eventually reached six hundred thousand physicians[26] (by some reports his audience was a million[27] physicians in 20 countries). Sackler's marketing of Valium in journals like Medical Tribune helped to make it the first drug to generate $100 million in sales, and by 1971, Librium and Valium earned $2 billion for his client, Hoffmann-La Roche.[28] As a result of his success, many other drug companies began marketing their drugs in a similar fashion.[29]

Professor Evan Gerstmann wrote in Forbes, "Of course, fraudulent marketing is very wrong indeed. But it is an absurd inversion of logic to say that because Arthur Sackler pioneered direct marketing to physicians, he is responsible for the fraudulent misuse of that technique, even if the patient doctor relationship was irreversibly perverted due to his actions."[30]

Later career

[edit]

Sackler is credited with helping to racially integrate New York City's first blood banks.[31][32]

He was editor of the Journal of Clinical and Experimental Psychobiology from 1950 to 1962.[33]

Sackler had somewhat unusual overlapping businesses and developed silent partnerships with the L. W. Frolich ad agency and MD Publications owned by his friends.[11]

In 1958, Sackler established the Laboratories for Therapeutic Research. He was director of the facility until 1983.[13] Sackler also served as chairman of the board of Medical Press, Inc. and president of Physicians News Service, Inc., as well as the Medical Radio and TV Institute, Inc.[34] He served on the board of trustees of New York Medical College where he also held a position as a research professor of psychiatry.[35]

In 1981, Sackler served as vice-chairman of the first international conference on nutrition held in Tianjin, China.[36] He joined the board of directors of Scientific American in 1985.[37] In 1985, Linus Pauling dedicated his book How to Live Longer and Feel Better to him.[38] In 1997, Arthur was posthumously inducted into the Medical Advertising Hall of Fame.[39]

Philanthropy

[edit]

Sackler built and contributed to many scientific institutions, throughout the 1970s and 1980s. His notable contributions included:

Sackler donated drawings and paintings by the Italian architect and engraver Giovanni Battista Piranesi to Avery Library at Columbia University in the early 1970s.[10]

He founded galleries at the Metropolitan Museum of Art where the Sackler Wing houses the Temple of Dendur, and Princeton University, the Arthur M. Sackler Museum at Harvard University in Cambridge, Massachusetts, and the Arthur M. Sackler Museum of Art and Archaeology. In 1987, the Arthur M. Sackler Gallery of the Smithsonian Institution, in Washington, D.C. was opened months after his death, with a gift of $4 million and 1,000 original artworks.[1][41][42] Sackler's collection that was donated to the Smithsonian was considered the largest personal collection of ancient Chinese art in the world according to Wen Fong of the Metropolitan Museum of Art.[12] Following his death, The Jillian and Arthur M. Sackler Wing of Galleries was opened at the Royal Academy of Arts,[43] and the Arthur M. Sackler Museum of Art and Archaeology opened at Peking University in 1993.[19]

Philanthropy backlash

[edit]

The Sackler family name, including Arthur Sackler, saw increased scrutiny in the late 2010s over the family's association with OxyContin. David Crow, writing in the Financial Times, described the family name as "tainted" (cf. Tainted donors).[44][45]

In March 2019, the National Portrait Gallery and the Tate galleries announced that they would not accept further donations from the Sackler family. This came after the American photographer Nan Goldin threatened to withdraw a planned retrospective of her work in the National Portrait Gallery if the gallery accepted a £1 million donation from a Sackler fund.[46][47] In June 2019, NYU Langone Medical Center announced they will no longer be accepting donations from any Sacklers, and have since changed the name of the Sackler Institute of Graduate Biomedical Sciences to the Vilcek Institute of Graduate Biomedical Sciences.[48]

Later in 2019, the American Museum of Natural History, and the Solomon R. Guggenheim Museum and Metropolitan Museum of Art in New York, each announced they will not accept future donations from any Sacklers that were involved in Purdue Pharma.[49]

According to The New York Times, the Louvre in Paris was the first major museum to "erase its public association" with the Sackler family name. On July 16, 2019, the museum had removed the plaque at the gallery entrance about Sacklers’ donations made to the museum. Throughout the gallery, grey tape covered signs such as Sackler Wing, including signage for the Louvre's Persian and Levantine artifacts collection, which was removed on July 8 or 9. Signage for the collection had identified it as the Sackler Wing of Oriental Antiquities since 1997.[50]

On December 9, 2021, the Metropolitan Museum of Art in New York City, along with the Sackler family, announced the removal of the Sackler family name from seven named galleries, including the wing that houses the iconic Temple of Dendur.[51]

The family's philanthropy has been characterized as "reputation laundering" from profits acquired from the selling of opiates.[52][53]

Personal life

[edit]

Sackler was married three times.[10] His first wife was Else Finnich Jorgensen from Denmark; they married in 1934, had two children, and divorced. His second wife was Marietta Lutze (1919–2019),[54] co-owner of DR. KADE Pharmazeutische Fabrik GmbH;[55] whom he married in 1949. They had two children and divorced after 25 years of marriage. His last wife until his death was Jillian Lesley Tully who directs philanthropic projects in his name through the Dame Jillian Sackler and Arthur M. Sackler Foundation for the Arts, Sciences and Humanities.[56] Sackler had four children, Carol Master and Elizabeth Sackler from his first marriage, and Arthur F. Sackler and Denise Marika from the second.[1][54][57]

He lived on Fifth Avenue in New York.[10] At nearly 70 years old, he maintained a full-time work schedule, starting work at 8:30 A.M. seven days a week, traveling to Boston and Washington, DC, to conduct scholarship, to work on science, and to collect art.[11] Sackler died of a heart ailment at Presbyterian Hospital in New York City on May 26, 1987.[10]

Awards and honors

[edit]

Sackler received honorary doctorates from Clark University, Hahnemann University, Tufts University, and Mount Sinai School of Medicine. He was a member of the American Academy of Arts and Sciences and was awarded the Egyptian Order of Merit. He and his wife Jillian endowed the Arthur M. Sackler Colloquia which are held at the National Academy of Sciences.[58]

Purdue Pharma controversy

[edit]

In 1952, Sackler arranged financing for his brothers to purchase the Purdue-Frederick Company. Purdue came to sell practical over-the-counter products like the antiseptic Betadine, the laxative Senokot, and earwax remover Cerumenex.[6] The company also sold MS Contin,[59] or morphine with time-release properties, for which the patent was to expire in the late 1980s.[9] Following Arthur's death in 1987, his option on one third of that company was sold by his estate to his brothers Mortimer and Raymond,[60] who owned the separate company named Purdue Pharma and used Purdue-Frederick as a holding company.

Eight years after Arthur's death, Purdue began selling OxyContin, about 1.5 times the strength of morphine, under the direction of his brothers.[61] That company pleaded guilty in 2007 and was fined $640 million for misbranding OxyContin.[62] Critics of the Sackler family and Purdue contend that the same marketing techniques used when Arthur consulted to pharmaceutical companies selling non-opioid medications were later abused in the marketing of OxyContin by his brothers and his nephew, Richard Sackler, contributing to the opioid epidemic. According to a quote in The Guardian, “This is essentially a crime family … drug dealers in nice suits and dresses.”[63]

Criticism

[edit]

Senator Estes Kefauver's subcommittee examined the pharmaceutical industry in 1959. He felt that Arthur Sackler possessed an "integrated" empire of drug discovery and manufacture, drug marketing and advertising, and medical publications explicitly for promoting drug sales.[9] He stopped investigating Sackler in mid-1960. He sponsored the Kefauver Harris Amendment which improved FDA drug oversight in 1962.[24]

Barry Meier wrote in his book Pain Killer that Sackler, "helped pioneer some of the most controversial and troubling practices in medicine: the showering of favors on doctors, the lavish spending on consultants and experts ready to back a drugmaker’s claims, the funding of supposedly independent commercial interest groups, the creation of publications to serve as industry mouthpieces, and the outright exploitation of scientific research for marketing purposes."[64]

Psychiatrist Allen Frances told The New Yorker in 2017, “Most of the questionable practices that propelled the pharmaceutical industry into the scourge it is today can be attributed to Arthur Sackler.”[26][65] Patrick Radden Keefe, author of the 2017 The New Yorker article later expanded his work into a full-length book Empire of Pain. The book was released in 2021 and was highly critical of the Sackler family, including Arthur Sackler's efforts to hide his numerous conflicts of interest while amassing his fortune.

See also

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References

[edit]
  1. ^ a b c d Glueck, Grace (May 27, 1987). "Dr. Arthur Sackler Dies at 73; Philanthropist and Art Patron". The New York Times. Retrieved May 11, 2014.
  2. ^ Smith, J.Y. (May 27, 1987). "Arthur Sackler dies at 73". The Washington Post. Retrieved December 31, 2017.
  3. ^ "In the Matter of The Estate of Arthur M. Sackler, Deceased". Leagle. Retrieved May 17, 2019.
  4. ^ "The Metropolitan Museum of Art and Sackler Families Announce Removal of the Family Name in Dedicated Galleries". The Metropolitan Museum of Art.
  5. ^ Shapiro, Edward S. (May 1, 1995). A Time for Healing: American Jewry Since World War II. Johns Hopkins University Press. p. 120. ISBN 9780801851247.
  6. ^ a b Langer, Emily (July 21, 2017). "Raymond Sackler, philanthropist and maker of OxyContin, dies at 97". The Washington Post. Retrieved May 11, 2019.
  7. ^ Walters, Joanna (February 13, 2018). "Meet the Sacklers: the family feuding over blame for the opioid crisis". The Guardian. Retrieved May 11, 2019.
  8. ^ "Famous Alumni". Erasmus Hall Alumni Association. Archived from the original on September 22, 2018. Retrieved May 13, 2019.
  9. ^ a b c d e Patrick Radden Keefe (October 23, 2017). "The Family That Built an Empire of Pain". The New Yorker. Condé Nast. Retrieved May 11, 2019.
  10. ^ a b c d e f "Arthur Sackler Dies at 73". The Washington Post. May 27, 1987.
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  12. ^ a b c Tuck, Lon (September 21, 1986). "Convictions of the Collector". The Washington Post.
  13. ^ a b c The Role of Science in Solving the Earth Emerging Water Problems. National Academies Press. September 15, 2005.
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  15. ^ a b c d e Sackler, Mortimer D., MD; Sackler, Raymond R., MD; Sackler, Arthur M., MD; Van Ophuijsen, J. H. W., MD (January 1951). "The Technique of Histamine Biochemo-therapy and Suggestions for its Use in Psychiatry". The Journal of Nervous and Mental Disease. 113 (1): 40–51. doi:10.1097/00005053-195101000-00003. PMID 14814544. S2CID 35613071.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  16. ^ Lucy, John D. (1954). "Histamine Tolerance in Schizophrenia". Archives of Neurology and Psychiatry. 71 (5): 629–639. doi:10.1001/archneurpsyc.1954.02320410091010. PMID 13157694.
  17. ^ Rice, Todd W. (October 2008). "The Historical, Ethical, and Legal Background of Human-Subjects Research". Respiratory Care. 53 (10): 1325–1329. PMID 18811995.
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  19. ^ a b "Arthur M. Sackler, M.D." National Academy of Sciences.
  20. ^ a b "Missing Art Objects from the Dr. Paul Singer Collection of Chinese Art". Freer Gallery of Art & Arthur M. Sackler Gallery. Retrieved July 19, 2020.
  21. ^ Cotter, Holland (September 15, 1999). "CRITIC'S NOTEBOOK: A Gift Shines Light Upon Ancient China; 5,000-Piece Art Collection Tells Some Unusual Tales". The New York Times. Retrieved May 12, 2019.
  22. ^ "MAHF Inductees Arthur M. Sackler". Medical Advertising Hall of Fame. October 18, 2013.
  23. ^ "Arthur M. Sackler". Medical Advertising Hall of Fame. October 18, 2013. Retrieved May 10, 2019.
  24. ^ a b c d e Podolsky, Scott H., MD; Herzberg, David, Ph.D.; Greene, Jeremy A., Ph.D. MD (2019). "Preying on Prescribers (and Their Patients) — Pharmaceutical Marketing, Iatrogenic Epidemics, and the Sackler Legacy". N Engl J Med. 380 (19): 1785–1787. doi:10.1056/NEJMp1902811. PMID 30969504. S2CID 106409881.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  25. ^ Morrell, Alex (July 1, 2015). "The OxyContin Clan: The $14 Billion Newcomer to Forbes 2015 List of Richest U.S. Families". Forbes. Retrieved May 11, 2019.
  26. ^ a b Keefe, Patrick Radden (October 23, 2017). "The Family That Built an Empire of Pain". The New Yorker. ISSN 0028-792X. Retrieved February 2, 2019.
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  30. ^ Gerstmann, Evan (May 10, 2019). "Harvard, Arthur Sackler And The Perils Of Indiscriminate Shaming". Forbes. Retrieved May 13, 2019.
  31. ^ "Art and activism: The compass points of Elizabeth Sackler's storied career". Women in the World. January 8, 2016. Archived from the original on May 27, 2020. Retrieved March 18, 2018.
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  34. ^ The Competitive Status of the U.S. Pharmaceutical Industry: The Influences of Technology in Determining International Industrial Competitive Advantage. National Academies. January 1, 1983.
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  37. ^ "For Sale: Scientific American". The New York Times. March 29, 1986.
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  39. ^ "Medical Advertising Hall of Fame Inductees". Medical Advertising Hall of Fame. October 18, 2013. Retrieved December 29, 2017.
  40. ^ "Tel Aviv University and the Sackler Family Agreed to Remove the Name Sackler from the Faculty of Medicine". Tel Aviv University. June 22, 2023. Retrieved July 12, 2023.
  41. ^ Karl E. Meyer, Shareen Blair Brysac (March 10, 2015). The China Collectors: America's Century-Long Hunt for Asian Art Treasures. Macmillan.
  42. ^ Glueck, Grace (October 18, 1985). "Sackler Art Museum to Open at Harvard". The New York Times.
  43. ^ "Arthur M. Sackler Foundation Donates Works of Art". Mount Holyoke College Art Museum. June 10, 2015.
  44. ^ David Crow (September 8, 2018). "What next for the Sacklers? A pharma dynasty under siege". Financial Times. Archived from the original on December 11, 2022. Retrieved February 24, 2019.
  45. ^ David Armstrong (February 21, 2019). "Sackler Embraced Plan to Conceal OxyContin's Strength From Doctors, Sealed Testimony Shows". ProPublica. Retrieved February 27, 2019.
  46. ^ "Tate art galleries will no longer accept donations from the Sackler family". Guardian. March 22, 2019. Retrieved March 22, 2019.
  47. ^ Walters, Joanna. "Nan Goldin threatens London gallery boycott over £1m gift from Sackler fund". The Guardian. Retrieved March 23, 2019.
  48. ^ Youn, Soo. "NYU Langone no longer accepting donations from the Sacklers, the family that owns OxyContin maker Purdue Pharma". ABC News. Retrieved December 19, 2019.
  49. ^ Harris, Elizabeth A. (May 15, 2019). "The Met Will Turn Down Sackler Money Amid Fury Over the Opioid Crisis". The New York Times. Retrieved May 17, 2019.
  50. ^ Marshall, Alex (July 17, 2019). "Louvre Removes Sackler Family Name From Its Walls". The New York Times. ISSN 0362-4331. Retrieved July 17, 2019.
  51. ^ "The Metropolitan Museum of Art and Sackler Families Announce Removal of the Family Name in Dedicated Galleries". The Metropolitan Museum of Art.
  52. ^ "New Yorker Sackler Article". newyorker.com. October 23, 2017. Retrieved October 17, 2018.
  53. ^ Frances, Allen (February 16, 2018). "Sackler Blood Money disgraces museums". The Guardian. theguardian.com. Retrieved October 17, 2018.
  54. ^ a b "Obituary Marietta Lutze Sackler". legacy.com. Retrieved May 13, 2019.
  55. ^ "Marietta Lutze Sackler, Former Co-Owner at DR. KADE Pharmazeutische Fabrik GmbH - Relationship Science". relationshipscience.com. Retrieved May 13, 2019.
  56. ^ "Smithsonian's Sackler Gallery celebrates 25th anniversary". The Washington Post. December 2, 2012.
  57. ^ "Denise, Marika". Legacy.com. Retrieved November 17, 2021.
  58. ^ "Arthur M. Sackler Colloquia". National Academy of Sciences. Retrieved May 12, 2019.
  59. ^ "MS CONTIN" (PDF). US FDA. Retrieved May 13, 2019.
  60. ^ "Our Incomplete List of Cultural Institutions and Initiatives Funded by the Sackler Family". Hyperallergic. January 11, 2018. Retrieved March 19, 2018.
  61. ^ "Elizabeth A. Sackler Supports Nan Goldin in Her Campaign Against OxyContin". Hyperallergic. January 22, 2018. Retrieved January 23, 2018.
  62. ^ Meier, Barry (May 10, 2007). "In Guilty Plea, OxyContin Maker to Pay $600 Million". The New York Times. Retrieved May 13, 2019.
  63. ^ Walters, Joanna (November 19, 2018). "Sackler family members face mass litigation and criminal investigations over opioids crisis". The Guardian.
  64. ^ Meier, Barry (2018). Pain Killer: An Empire of Deceit and the Origin of America's Opioid Epidemic. p. 52. ISBN 978-0525511090
  65. ^ "The Secretive Family Making Billions From the Opioid Crisis". Esquire. October 16, 2017. Retrieved October 22, 2017.
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