PKN3 is a protein kinase C-related molecule and thought to be an effector mediating malignant cell growth downstream of activated phosphoinositide 3-kinase (PI3K).[5] It is thought that chronic activation of the phosphoinositide 3-kinase (PI3K)/PTENsignal transduction pathway contributes to metastatic cell growth and that PKN3 may mediate that growth.1
PKN3 is required for invasive prostate cell growth as assessed by 3D cell culture assays and in an orthotopic mouse tumor model by inducible expression of short hairpin RNA (shRNA). PKN3 may represent a target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of PI3K.
^Shibata H, Oishi K, Yamagiwa A, Matsumoto M, Mukai H, Ono Y (July 2001). "PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family". Journal of Biochemistry. 130 (1): 23–31. doi:10.1093/oxfordjournals.jbchem.a002958. PMID11432776.
Shibata H, Oishi K, Yamagiwa A, Matsumoto M, Mukai H, Ono Y (July 2001). "PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family". Journal of Biochemistry. 130 (1): 23–31. doi:10.1093/oxfordjournals.jbchem.a002958. PMID11432776.
Oishi K, Mukai H, Shibata H, Takahashi M, Ona Y (August 1999). "Identification and characterization of PKNbeta, a novel isoform of protein kinase PKN: expression and arachidonic acid dependency are different from those of PKNalpha". Biochemical and Biophysical Research Communications. 261 (3): 808–14. doi:10.1006/bbrc.1999.1116. PMID10441506.
