(Q38132274)

29 August 2017

title

Targeting VDAC-bound hexokinase II: a promising approach for concomitant anti-cancer therapy (English)

1 reference

29 August 2017

George S Krasnov

1

1 reference

29 August 2017

Alexey A Dmitriev

2

1 reference

29 August 2017

Valentina A Lakunina

3

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29 August 2017

Alexander A Kirpiy

4

1 reference

29 August 2017

Anna V Kudryavtseva

5

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29 August 2017

language of work or name

English

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publication date

28 August 2013

1 reference

Expert Opinion on Therapeutic Targets

29 August 2017

published in

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29 August 2017

volume

17

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29 August 2017

issue

10

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29 August 2017

page(s)

1221-1233

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Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function

29 August 2017

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Voltage-dependent anion channels (VDAC) in the plasma membrane play a critical role in apoptosis in differentiated hippocampal neurons but not in neural stem cells.

21 January 2018

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21 January 2018

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21 January 2018

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Warburg revisited: regulation of mitochondrial metabolism by voltage-dependent anion channels in cancer cells

21 January 2018

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21 January 2018

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In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death

21 January 2018

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The voltage-dependent anion channel: an essential player in apoptosis

21 January 2018

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Current concepts in apoptosis: the physiological suicide program revisited.

21 January 2018

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Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

21 January 2018

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Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

21 January 2018

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VDAC1: from structure to cancer therapy

21 January 2018

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Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Affixing N-terminal α-helix to the wall of the voltage-dependent anion channel does not prevent its voltage gating

21 January 2018

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Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

21 January 2018

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21 January 2018

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The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore

21 January 2018

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Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death

21 January 2018

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NMR structural investigation of the mitochondrial outer membrane protein VDAC and its interaction with antiapoptotic Bcl-xL.

21 January 2018

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21 January 2018

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Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak

21 January 2018

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On the role of VDAC in apoptosis: fact and fiction

21 January 2018

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Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt.

21 January 2018

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Mitochondrial hexokinases: guardians of the mitochondria

21 January 2018

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21 January 2018

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21 January 2018

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Deregulation of glycolysis in cancer: glyceraldehyde-3-phosphate dehydrogenase as a therapeutic target

21 January 2018

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21 January 2018

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GAPDH, a novel regulator of the pro-apoptotic mitochondrial membrane permeabilization

21 January 2018

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S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding

21 January 2018

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GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation

21 January 2018

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ASPicDB: a database of annotated transcript and protein variants generated by alternative splicing

21 January 2018

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AS-ALPS: a database for analyzing the effects of alternative splicing on protein structure, interaction and network in human and mouse.

21 January 2018

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Dysregulation of glucose transport, glycolysis, TCA cycle and glutaminolysis by oncogenes and tumor suppressors in cancer cells

21 January 2018

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Roles of p53, MYC and HIF-1 in regulating glycolysis - the seventh hallmark of cancer

21 January 2018

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Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

21 January 2018

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Regulation of cancer cell metabolism

21 January 2018

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Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking

21 January 2018

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MYC-induced cancer cell energy metabolism and therapeutic opportunities

21 January 2018

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The interplay between MYC and HIF in cancer.

21 January 2018

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Choosing between glycolysis and oxidative phosphorylation: A tumor's dilemma?

21 January 2018

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Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53

21 January 2018

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Glucose catabolism in cancer cells: regulation of the Type II hexokinase promoter by glucose and cyclic AMP.

21 January 2018

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AMP-activated protein kinase phosphorylates transcription factors of the CREB family

21 January 2018

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Androgen stimulates glycolysis for de novo lipid synthesis by increasing the activities of hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 in prostate cancer cells.

21 January 2018

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Hexokinase-I protection against apoptotic cell death is mediated via interaction with the voltage-dependent anion channel-1: mapping the site of binding.

21 January 2018

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The regulation of apoptosis by the downstream regulatory element antagonist modulator/potassium channel interacting protein 3 (DREAM/KChIP3) through interactions with hexokinase I.

21 January 2018

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Regulation and cytoprotective role of hexokinase III

21 January 2018

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Hexokinase III, cyclin A and galectin-3 are overexpressed in malignant follicular thyroid nodules

21 January 2018

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Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

21 January 2018

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MicroRNA-143 down-regulates Hexokinase 2 in colon cancer cells

21 January 2018

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A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells

21 January 2018

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miR-143 regulates hexokinase 2 expression in cancer cells

21 January 2018

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Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe.

21 January 2018

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STATs in cancer inflammation and immunity: a leading role for STAT3

21 January 2018

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SOCS1: a potent and multifaceted regulator of cytokines and cell-mediated inflammation.

21 January 2018

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MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene

21 January 2018

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Hexokinase type II: a novel tumor-specific promoter for gene-targeted therapy differentially expressed and regulated in human cancer cells

21 January 2018

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Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis

21 January 2018

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Hexokinase II and VEGF expression in liver tumors: correlation with hypoxia-inducible factor 1 alpha and its significance.

21 January 2018

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Expressions of hypoxia-inducible factor-1α and hexokinase-II in gastric adenocarcinoma: the impact on prognosis and correlation to clinicopathologic features.

21 January 2018

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Generating evidence for clinical benefit of PET/CT in diagnosing cancer patients

21 January 2018

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Diagnostic Imaging of Colorectal Liver Metastases with CT, MR Imaging, FDG PET, and/or FDG PET/CT: A Meta-Analysis of Prospective Studies Including Patients Who Have Not Previously Undergone Treatment

21 January 2018

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18FDG PET for grading malignancy in thymic epithelial tumors: Significant differences in 18FDG uptake and expression of glucose transporter-1 and hexokinase II between low and high-risk tumors: Preliminary study

21 January 2018

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The inhibition of hexokinase by disulphides

21 January 2018

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2-Deoxyglucose treatment complements the cisplatin- or BH3-only mimetic-induced suppression of neuroblastoma cell growth

21 January 2018

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2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo

21 January 2018

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The glycolytic inhibitor 2-deoxy-D-glucose enhances the efficacy of etoposide in ehrlich ascites tumor-bearing mice

21 January 2018

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Phase II study of lonidamine and diazepam in the treatment of recurrent glioblastoma multiforme

21 January 2018

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Paclitaxel, cisplatin and lonidamine in advanced ovarian cancer. A phase II study

21 January 2018

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bcl-2 inhibits mitochondrial metabolism and lonidamine-induced apoptosis in adriamycin-resistant MCF7 cells

21 January 2018

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Mitochondrial targeting drug lonidamine triggered apoptosis in doxorubicin-resistant HepG2 cells.

21 January 2018

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Increased apoptotic efficacy of lonidamine plus arsenic trioxide combination in human leukemia cells. Reactive oxygen species generation and defensive protein kinase (MEK/ERK, Akt/mTOR) modulation.

21 January 2018

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Therapeutic efficacy and safety of paclitaxel/lonidamine loaded EGFR-targeted nanoparticles for the treatment of multi-drug resistant cancer

21 January 2018

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Targeting aerobic glycolysis: 3-bromopyruvate as a promising anticancer drug

21 January 2018

1 reference

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Over-expression of GAPDH in human colorectal carcinoma as a preferred target of 3-bromopyruvate propyl ester

21 January 2018

1 reference

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3-bromopyruvate: a new targeted antiglycolytic agent and a promise for cancer therapy

21 January 2018

1 reference

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Enhancement of hexokinase II inhibitor-induced apoptosis in hepatocellular carcinoma cells via augmenting ER stress and anti-angiogenesis by protein disulfide isomerase inhibition

21 January 2018

1 reference

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Inhibition of hypoxia-inducible carbonic anhydrase-IX enhances hexokinase II inhibitor-induced hepatocellular carcinoma cell apoptosis

21 January 2018

1 reference

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Disruption of the hexokinase-VDAC complex for tumor therapy

21 January 2018

1 reference

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Role of mitochondria-associated hexokinase II in cancer cell death induced by 3-bromopyruvate

21 January 2018

1 reference

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Local toxicity of hepatic arterial infusion of hexokinase II inhibitor, 3-bromopyruvate: In vivo investigation in normal rabbit model.

21 January 2018

1 reference

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Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.833607

Methyl jasmonate binds to and detaches mitochondria-bound hexokinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.833607

The anti-cancer activities of jasmonates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.833607

Methyljasmonate displays in vitro and in vivo activity against multiple myeloma cells

21 January 2018

1 reference

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Methyl jasmonate: a plant stress hormone as an anti-cancer drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.833607

Effects of natural and novel synthetic jasmonates in experimental metastatic melanoma

21 January 2018

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Gene expression profiles in differentiating leukemia cells induced by methyl jasmonate are similar to those of cytokinins and methyl jasmonate analogs induce the differentiation of human leukemia cells in primary culture

21 January 2018

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PI3K/Akt pathway activation attenuates the cytotoxic effect of methyl jasmonate toward sarcoma cells

21 January 2018

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Casiopeína IIgly-induced oxidative stress and mitochondrial dysfunction in human lung cancer A549 and H157 cells

21 January 2018

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Casiopeina II-gly and bromo-pyruvate inhibition of tumor hexokinase, glycolysis, and oxidative phosphorylation.

21 January 2018

1 reference

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Oroxylin A sensitizes non-small cell lung cancer cells to anoikis via glucose-deprivation-like mechanisms: c-Src and hexokinase II.

21 January 2018

1 reference

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Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma

21 January 2018

1 reference

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Response to trastuzumab by HER2 expressing breast tumour xenografts is accompanied by decreased Hexokinase II, glut1 and [18F]-FDG incorporation and changes in 31P-NMR-detectable phosphomonoesters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.833607

Combined RNA interference of hexokinase II and (131)I-sodium iodide symporter gene therapy for anaplastic thyroid carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.833607

Low expression of sodium iodide symporter identifies aggressive thyroid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.833607

Human sodium-iodide symporter (hNIS) gene expression is inhibited by a trans-active transcriptional repressor, NIS-repressor, containing PARP-1 in thyroid cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.833607

Combined radionuclide-chemotherapy and in vivo imaging of hepatocellular carcinoma cells after transfection of a triple-gene construct, NIS, HSV1-sr39tk, and EGFP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.833607

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.833607

LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.833607

Activating oxidative phosphorylation by a pyruvate dehydrogenase kinase inhibitor overcomes sorafenib resistance of hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.833607

Inhibition of Liver Hexokinase by Dehydroascorbic Acid and Alloxan

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.833607

10.1517/14728222.2013.833607

21 January 2018

Identifiers

DOI

1 reference

29 August 2017

1 reference