(Q419319)

imported from Wikimedia project

inferred from InChIKey

has use

medication

0 references

chemical structure

Bortezomib.svg
512 × 357; 6 KB

1 reference

German Wikipedia

mass

384.197 dalton

1 reference

179324-69-7 (English)

N-[(1R)-1-Borono-3-methylbutyl]-Nalpha-(pyrazine-2-carbonyl)-D-phenylalaninamide

19 October 2016

stereoisomer of

2 references

inferred from InChIKey

N-[(1S)-1-Borono-3-methylbutyl]-Nalpha-(pyrazine-2-carbonyl)-L-phenylalaninamide

inferred from InChI

1 reference

inferred from InChIKey

chemical formula

C₁₉H₂₅BN₄O₄

1 reference

179324-69-7 (English)

19 November 2016

canonical SMILES

B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O

1 reference

179324-69-7 (English)

19 November 2016

isomeric SMILES

B([C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O

1 reference

179324-69-7 (English)

European Medicines Agency product number

19 November 2016

active ingredient in

Bortezomib Accord

1 reference

EMEA/H/C/003984

reference URL

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/003984/human_med_001882.jsp

European Medicines Agency product number

22 March 2017

Bortezomib Hospira

1 reference

EMEA/H/C/004207

reference URL

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/004207/human_med_001995.jsp

European Medicines Agency product number

22 March 2017

Bortezomib Sun

1 reference

EMEA/H/C/004076

reference URL

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/004076/human_med_001996.jsp

22 March 2017

1 reference

14 February 2018

World Health Organisation international non-proprietary name

bortezomib (English)

1 reference

bortezomib (English)

medical condition treated

19 October 2016

1 reference

13 December 2016

1 reference

2 October 2018

plasmacytoma

1 reference

2 October 2018

mantle cell lymphoma

1 reference

Waldenström macroglobulinemia

2 October 2018

1 reference

precursor T-cell lymphoblastic leukemia

2 October 2018

1 reference

2 October 2018

acute myeloid leukemia

1 reference

2 October 2018

non-Hodgkin lymphoma

1 reference

2 October 2018

plasma cell leukemia

1 reference

2 October 2018

B-cell lymphoma

1 reference

diffuse large B-cell lymphoma

2 October 2018

1 reference

significant drug interaction

2 October 2018

fosphenytoin

side effect

peripheral neuropathy

1 reference

sourcing circumstances

hypothetically

A reference set of clinically relevant adverse drug-drug interactions

phenytoin

side effect

peripheral neuropathy

1 reference

sourcing circumstances

hypothetically

A reference set of clinically relevant adverse drug-drug interactions

physically interacts with

Proteasome 20S subunit beta 5

subject has role

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

6391

Australian pregnancy category C

17 August 2016

pregnancy category

1 reference

imported from Wikimedia project

English Wikipedia

US pregnancy category D

1 reference

imported from Wikimedia project

English Wikipedia

LiverTox likelihood score

LiverTox toxicity likelihood category C

1 reference

8 April 2021

https://www.ncbi.nlm.nih.gov/books/n/livertox/Bortezomib

30 September 2017

1 reference

https://www.pfizer.com/products/product-list

subject has role

antineoplastic

1 reference

InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1

Medical Subject Headings

15 March 2018

Bortezomib

0 references

Identifiers

InChI

1 reference

179324-69-7 (English)

19 November 2016

InChIKey

2 references

179324-69-7 (English)

19 November 2016

ChEBI release 2020-09-01

CAS Registry Number

179324-69-7

2 references

Global Substance Registration System

UNII

69G8BD63PP

bortezomib (English)

19 November 2016

https://commonchemistry.cas.org/detail?cas_rn=179324-69-7

9 April 2021

1 reference

Bortezomib (English)

19 November 2016

2 references

179324-69-7 (English)

matched by identifier from

19 November 2016

InChIKey

Reaxys registry number

8723817

1 reference

bortezomib (English)

19 October 2016

mapping relation type

2 references

BORTEZOMIB (English)

matched by identifier from

19 November 2016

International Chemical Identifier

InChI

InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1

1 reference

splash10-016r-1397000000-e168634cfe7e1453d742

BORTEZOMIB (English)

19 November 2016

1 reference

0 references

HSDB ID

7666

1 reference

Hazardous Substances Data Bank

28 October 2019

BORTEZOMIB (English)

10 May 2021

2 references

Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard

matched by identifier from

InChIKey

DSSTOX compound identifier

0 references

0 references

0 references

0 references

ECHA Substance Infocard ID

100.125.601

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.125.601

27 December 2018

N,N',N''-((2S,2'S,2''S)-(((1R,1'R,1''R)-(1,3,5,2,4,6-trioxatriborinane-2,4,6-triyl)tris(3-methylbutane-1,1-diyl))tris(azanediyl))tris(1-oxo-3-phenylpropane-2,1-diyl))tris(pyrazine-2-carboxamide) (English)

quotation

CAS no.: 179324-69-7 (English)

1 reference