(Q56241031)

English

ABL1 P-Loop Mutation

genetic variant

P-Loop Mutation

In more languages

default for all languages

No label defined

No description defined

Statements

biological variant of

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/2375

negative therapeutic predictor for

determination method or standard

CIViC evidence level B

CIViC 3-star trust rating

medical condition treated

chronic myeloid leukemia

statement disputed by

Safety and efficacy of bosutinib (SKI-606) in chronic phase Philadelphia chromosome-positive chronic myeloid leukemia patients with resistance or intolerance to imatinib

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/6336

Safety and efficacy of bosutinib (SKI-606) in chronic phase Philadelphia chromosome-positive chronic myeloid leukemia patients with resistance or intolerance to imatinib

determination method or standard

CIViC evidence level B

CIViC 2-star trust rating

medical condition treated

chronic myeloid leukemia

statement disputed by

Bosutinib is active in chronic phase chronic myeloid leukemia after imatinib and dasatinib and/or nilotinib therapy failure

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/6997

Bosutinib is active in chronic phase chronic myeloid leukemia after imatinib and dasatinib and/or nilotinib therapy failure

determination method or standard

CIViC evidence level C

CIViC 2-star trust rating

medical condition treated

chronic myeloid leukemia

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/evidence/8094

Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis

Identifiers

CIViC variant ID

1 reference

23 May 2022

https://civic.genome.wustl.edu/links/variants/2375

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