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PRPS1 L191F
genetic variant
L191F
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Statements
biological variant of
PRPS1
1 reference
stated in
CIViC database
retrieved
28 March 2022
reference URL
https://civic.genome.wustl.edu/links/variants/2919
positive therapeutic predictor for
cytarabine
determination method or standard
CIViC evidence level D
rating
CIViC 2-star trust rating
medical condition treated
B-cell childhood acute lymphoblastic leukemia
1 reference
curator
CIViC database
retrieved
28 March 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/7911
stated in
Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL.
Identifiers
CIViC variant ID
2919
1 reference
stated in
CIViC database
retrieved
28 March 2022
reference URL
https://civic.genome.wustl.edu/links/variants/2919
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