Beta-farnezenska sintaza
(Preusmjereno sa stranice TPS10)
Beta-farnezenska sintaza (EC 4.2.3.47, farnesene sintaza, terpen sintaza 10, terpen sintaza 10-B73, TPS10) je enzim sa sistematskim imenom (2E,6E)-farnezil-difosfat difosfat-lijaza (formira (E)-beta-farnezen).[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Beta-farnezenska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.3.47 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (2E,6E)-farnezil difosfat (E)-beta-farnezen + difosfat
Reference
uredi- ↑ Zhao, B., Lei, L., Vassylyev, D.G., Lin, X., Cane, D.E., Kelly, S.L., Yuan, H., Lamb, D.C. and Waterman, M.R. (2009). „Crystal structure of albaflavenone monooxygenase containing a moonlighting terpene synthase active site”. J. Biol. Chem. 284: 36711-36719. PMID 19858213.
- ↑ Picaud, S., Brodelius, M. and Brodelius, P.E. (2005). „Expression, purification and characterization of recombinant (E)-β-farnesene synthase from Artemisia annua”. Phytochemistry 66: 961-967. PMID 15896363.
- ↑ Kollner, T.G., Gershenzon, J. and Degenhardt, J. (2009). „Molecular and biochemical evolution of maize terpene synthase 10, an enzyme of indirect defense”. Phytochemistry 70: 1139-1145. PMID 19646721.
- ↑ Schnee, C., Kollner, T.G., Held, M., Turlings, T.C., Gershenzon, J. and Degenhardt, J. (2006). „The products of a single maize sesquiterpene synthase form a volatile defense signal that attracts natural enemies of maize herbivores”. Proc. Natl. Acad. Sci. USA 103: 1129-1134. PMID 16418295.
- ↑ Maruyama, T., Ito, M. and Honda, G. (2001). „Molecular cloning, functional expression and characterization of (E)-β farnesene synthase from Citrus junos”. Biol. Pharm. Bull. 24: 1171-1175. PMID 11642326.
- ↑ Crock, J., Wildung, M. and Croteau, R. (1997). „Isolation and bacterial expression of a sesquiterpene synthase cDNA clone from peppermint (Mentha × piperita, L.) that produces the aphid alarm pheromone (E)-β-farnesene”. Proc. Natl. Acad. Sci. USA 94: 12833-12838. PMID 9371761.
- ↑ Schnee, C., Kollner, T.G., Gershenzon, J. and Degenhardt, J. (2002). „The maize gene terpene synthase 1 encodes a sesquiterpene synthase catalyzing the formation of (E)-β-farnesene, (E)-nerolidol, and (E,E)-farnesol after herbivore damage”. Plant Physiol. 130: 2049-2060. PMID 12481088.
- ↑ Huber, D.P.W., Philippe, R.N., Godard, K.-A., Sturrock, R.N. and Bohlmann, J. (2005). „Characterization of four terpene synthase cDNAs from methyl jasmonate-induced Douglas-fir, Pseudotsuga menziesii”. Phytochemistry 66: 1427-1439. PMID 15921711.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.