TRNK pseudouridinska13 sintaza
(Preusmjereno sa stranice TRNA-uridine13 uracil mutase)
TRNK pseudouridinska13 sintaza (EC 5.4.99.27, TruD, YgbO, tRNK PSI13 sintaza, RNK:PSI-sintaza Pus7p, Pus7p, RNK:pseudouridin-sintaza Pus7p, Pus7 protein) je enzim sa sistematskim imenom tRNK-uridin13 uracil mutaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| TRNK pseudouridinska13 sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 5.4.99.27 | ||||||||
| CAS broj | 430429-15-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- tRNK uridin13 tRNK pseudouridin13
Pseudouridinska sintaza TruD iz Escherichia coli specifično deluje na uridin13 u tRNK.
Reference
uredi- ↑ Ericsson, U.B., Nordlund, P. and Hallberg, B.M. (2004). „X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold”. FEBS Lett. 565: 59-64. PMID 15135053.
- ↑ Chan, C.M. and Huang, R.H. (2009). „Enzymatic characterization and mutational studies of TruD—the fifth family of pseudouridine synthases”. Arch. Biochem. Biophys. 489: 15-19. PMID 19664587.
- ↑ Kaya, Y. and Ofengand, J. (2003). „A novel unanticipated type of pseudouridine synthase with homologs in bacteria, archaea, and eukarya”. RNA 9: 711-721. PMID 12756329.
- ↑ Behm-Ansmant, I., Urban, A., Ma, X., Yu, Y.T., Motorin, Y. and Branlant, C. (2003). „The Saccharomyces cerevisiae U2 snRNA:pseudouridine-synthase Pus7p is a novel multisite-multisubstrate RNA:Ψ-synthase also acting on tRNAs”. RNA 9: 1371-1382. PMID 14561887.
- ↑ Urban, A., Behm-Ansmant, I., Branlant, C. and Motorin, Y. (2009). „RNA sequence and two-dimensional structure features required for efficient substrate modification by the Saccharomyces cerevisiae RNA:Ψ-synthase Pus7p”. J. Biol. Chem. 284: 5845-5858. PMID 19114708.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.