Izvorni kod stranice Endonukleaza specifična za strukturu prepusta 1

{{PBB|geneid=2237}}
'''Flap endonukleaza 1''' je [[enzim]] koji je kod ljudi kodiran ''FEN1'' [[gen]]om.<ref name="pmid7774922">{{cite journal | author = Hiraoka LR, Harrington JJ, Gerhard DS, Lieber MR, Hsieh CL | title = Sequence of human FEN-1, a structure-specific endonuclease, and chromosomal localization of the gene (FEN1) in mouse and human | journal = Genomics | volume = 25 | issue = 1 | pages = 220–5 |date=Jul 1995 | pmid = 7774922 | pmc =  | doi =10.1016/0888-7543(95)80129-A  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FEN1 flap structure-specific endonuclease 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2237| accessdate = }}</ref>

Protein kodiran ovim genom uklanja 5' prepuste tokom DNK popravke i obrađuje 5' krajeve [[Okazakijev fragment|Okazakijevih fragmenta]] pri sintezi zaostajućeg lanca DNK. Direktna fizička interakcija između tog proteina i AP endonukleaze 1 tokom popravke isecanjem dugog segmenta baza omogućava koordinirani pristup proteina supstratu, čime se supstrat dodaje od jednog enzima do drugog. Ovaj protein je član XPG/RAD2 familije endonukleaza i jedan je od deset proteina koji su esencijalni za bezćelijsku replikaciju DNK. Sekundarna struktura DNK može da inhibira flap obradu na pojedinim trinukleotidnim ponavljanjima u maniru zavisnom od dužine koji skrivaju 5' kraj prepusta, koji je neophodan za vezivanje i presecanje proteinom kodiranim ovim genom. Stoga sekundarna struktura može da onemogući protektivnu funkciju ovog proteina, što dovodi do trinukleotidnih ekspanzija specifičnih za mesto.<ref name="entrez" />

== Interakcije ==
Endonukleaza 1 specifična za flap strukturu formia [[Protein-protein interakcija|interakcije]] sa [[Ciklin-zavisna kinaza 2]],<ref name=pmid12853968>{{cite journal |last=Henneke |first=Ghislaine |authorlink= |author2=Koundrioukoff Stéphane |author3=Hübscher Ulrich  |date=Jul 2003 |title=Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulation |journal=Oncogene |volume=22 |issue=28 |pages=4301–13 |publisher= |location = England| issn = 0950-9232| pmid = 12853968 |doi = 10.1038/sj.onc.1206606 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[EP300]],<ref name=pmid11430825>{{cite journal |doi=10.1016/S1097-2765(01)00272-6 |last=Hasan |first=S |authorlink= |author2=Stucki M |author3=Hassa P O |author4=Imhof R |author5=Gehrig P |author6=Hunziker P |author7=Hübscher U |author8=Hottiger M O  |date=Jun 2001 |title=Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300 |journal=Mol. Cell |volume=7 |issue=6 |pages=1221–31 |publisher= |location = United States| issn = 1097-2765| pmid = 11430825 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[ATP-zavisna helikaza Vernerovog sindroma]],<ref name=pmid14688284>{{cite journal |last=Sharma |first=Sudha |authorlink= |author2=Sommers Joshua A |author3=Wu Leonard |author4=Bohr Vilhelm A |author5=Hickson Ian D |author6=Brosh Robert M  |date=Mar 2004 |title=Stimulation of flap endonuclease-1 by the Bloom's syndrome protein |journal=J. Biol. Chem. |volume=279 |issue=11 |pages=9847–56 |publisher= |location = United States| issn = 0021-9258| pmid = 14688284 |doi = 10.1074/jbc.M309898200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11598021>{{cite journal |last=Brosh |first=R M |authorlink= |author2=von Kobbe C |author3=Sommers J A |author4=Karmakar P |author5=Opresko P L |author6=Piotrowski J |author7=Dianova I |author8=Dianov G L |author9=Bohr V A  |displayauthors=9 |date=Oct 2001 |title=Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity |journal=EMBO J. |volume=20 |issue=20 |pages=5791–801 |publisher= |location = England| issn = 0261-4189| pmid = 11598021 |doi = 10.1093/emboj/20.20.5791 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=125684 }}</ref> [[Heterogeni nuklearni ribonukleoprotein A1]],<ref name=pmid14690413>{{cite journal |last=Chai |first=Qing |authorlink= |author2=Zheng Li |author3=Zhou Mian |author4=Turchi John J |author5=Shen Binghui  |date=Dec 2003 |title=Interaction and stimulation of human FEN-1 nuclease activities by heterogeneous nuclear ribonucleoprotein A1 in alpha-segment processing during Okazaki fragment maturation |journal=Biochemistry |volume=42 |issue=51 |pages=15045–52 |publisher= |location = United States| issn = 0006-2960| pmid = 14690413 |doi = 10.1021/bi035364t | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Ciklin A2]],<ref name=pmid12853968/> [[PCNA]],<ref name=pmid12853968/><ref name=pmid11430825/><ref name=pmid9545252>{{cite journal |last=Jónsson |first=Z O |authorlink= |author2=Hindges R |author3=Hübscher U  |date=Apr 1998 |title=Regulation of DNA replication and repair proteins through interaction with the front side of proliferating cell nuclear antigen |journal=EMBO J. |volume=17 |issue=8 |pages=2412–25 |publisher= |location = ENGLAND| issn = 0261-4189| pmid = 9545252 |doi = 10.1093/emboj/17.8.2412 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1170584 }}</ref><ref name=pmid9305916>{{cite journal |doi=10.1074/jbc.272.39.24522 |last=Gary |first=R |authorlink= |author2=Ludwig D L |author3=Cornelius H L |author4=MacInnes M A |author5=Park M S  |date=Sep 1997 |title=The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21 |journal=J. Biol. Chem. |volume=272 |issue=39 |pages=24522–9 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9305916 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid8876181>{{cite journal |doi=10.1073/pnas.93.21.11597 |last=Chen |first=U |authorlink= |author2=Chen S |author3=Saha P |author4=Dutta A  |date=Oct 1996 |title=p21Cip1/Waf1 disrupts the recruitment of human Fen1 by proliferating-cell nuclear antigen into the DNA replication complex |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=93 |issue=21 |pages=11597–602 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 8876181 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=38103 }}</ref><ref name=pmid11601988>{{cite journal |doi=10.1021/bi011117i |last=Dianova |first=I I |authorlink= |author2=Bohr V A |author3=Dianov G L  |date=Oct 2001 |title=Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair |journal=Biochemistry |volume=40 |issue=42 |pages=12639–44 |publisher= |location = United States| issn = 0006-2960| pmid = 11601988 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11313979>{{cite journal |last=Yu |first=P |authorlink= |author2=Huang B |author3=Shen M |author4=Lau C |author5=Chan E |author6=Michel J |author7=Xiong Y |author8=Payan D G |author9=Luo Y  |displayauthors=9 |date=Jan 2001 |title=p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues |journal=Oncogene |volume=20 |issue=4 |pages=484–9 |publisher= |location = England| issn = 0950-9232| pmid = 11313979 |doi = 10.1038/sj.onc.1204113 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Protein blum sindroma]]<ref name=pmid14688284/> i [[APEX1]].<ref name=pmid11601988/>

== Reference ==
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== Literatura ==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
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