O-fosfo-L-seril-tRNKSec:L-selenocisteinil-tRNK sintaza
(Preusmjereno sa stranice O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase)
O-fosfo-L-seril-tRNKSec:L-selenocisteinil-tRNK sintaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.9.1.2 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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O-fosfo-L-seril-tRNKSec:L-selenocisteinil-tRNK sintaza (EC 2.9.1.2, MMPSepSecS, SepSecS, SLA/LP, O-fosfoseril-tRNK:selenocisteinil-tRNK sintaza, O-fosfo-L-seril-tRNK:L-selenocisteinil-tRNK sintaza) je enzim sa sistematskim imenom selenofosfat:O-fosfo-L-seril-tRNKSec selenijum transferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- O-fosfo-L-seril-tRNKSec + selenofosfat L-selenocisteinil-tRNKSec + fosfat
Ovaj enzim je piridoksal-fosfatni protein.
- ↑ Palioura, S., Sherrer, R.L., Steitz, T.A., Soll, D. and Simonovic, M. (2009). „The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation”. Science 325: 321-325. PMID 19608919.
- ↑ Araiso, Y., Palioura, S., Ishitani, R., Sherrer, R.L., O'Donoghue, P., Yuan, J., Oshikane, H., Domae, N., Defranco, J., Soll, D. and Nureki, O. (2008). „Structural insights into RNA-dependent eukaryal and archaeal selenocysteine formation”. Nucleic Acids Res. 36: 1187-1199. PMID 18158303.
- ↑ Aeby, E., Palioura, S., Pusnik, M., Marazzi, J., Lieberman, A., Ullu, E., Soll, D. and Schneider, A. (2009). „The canonical pathway for selenocysteine insertion is dispensable in Trypanosomes”. Proc. Natl. Acad. Sci. USA 106: 5088-5092. PMID 19279205.
- ↑ Yuan, J., Palioura, S., Salazar, J.C., Su, D., O'Donoghue, P., Hohn, M.J., Cardoso, A.M., Whitman, W.B. and Soll, D. (2006). „RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea”. Proc. Natl. Acad. Sci. USA 103: 18923-18927. PMID 17142313.
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