- At 40 years old, he's the oldest person to start hosting NBC's "Late Night".
- He commuted to Saturday Night Live (1975) by subway from his apartment in the West Village.
- After a very short engagement, announced in the summer of 2013, Seth married his longtime girlfriend, lawyer Alexi Ashe Meyers, on Martha's Vineyard, Massachusetts, on the Sunday of Labor Day weekend, September 1, 2013.
- Older brother of Josh Meyers, a cast member of Mad TV (1995).
- In 2006, he was promoted to Weekend Update co-anchor on Saturday Night Live (1975) with Amy Poehler.
- Eventually, the road took him to Amsterdam, where he was the writer and co-star of a two-person comedy show called "Pick-ups and Hiccups" that he and Jill Benjamin staged five nights a week in a 200-seat theatre. With Amsterdam as his home base, he did versions of the show in London and Edinburgh--even Singapore--but it was during a brief run at the Chicago Improv Festival that he caught the eye of a Saturday Night Live (1975) casting director. He was invited to New York for a try-out, then a follow-up, and then he was hired.
- He sees three distinct Windows of Rejection, which refers to the fact that ideas on SNL have three different opportunities to get rejected before being aired.
- In August 2003, he was promoted to full cast member status of Saturday Night Live (1975) along with Jeff Richards and Will Forte.
- His father, Larry Meyers (Lawrence "Larry" Meyers Jr.), works with GE Trade Finance. His mother, Hilary Meyers (née Hilary Claire Olson), is a legendary teacher of French at McKelvie Middle School in Bedford, New Hampshire; she is known almost universally throughout the town as Madame Meyers.
- After graduating from Manchester West High School in Manchester, New Hampshire, he earned a degree from Northwestern University, then he took his act on the road. He worked with the traveling troupe of a group called Boom Chicago.
- An avid fan of the Boston Red Sox, he donated his Celebrity Poker Showdown winnings to the Jimmy Fund, which is a Boston-area charity that specializes in children's cancer treatment. It has been associated with the Red Sox for over 50 years.
- Seth's paternal grandfather, Lawrence Lashe Meyers, was the son of Lithuanian Jewish parents, while Seth's paternal grandmother, Barbara Marcheck, was from a family of Bohemian (Czech) and Croatian descent. Seth's mother is of English, German and Swedish descent. Seth discovered on Finding Your Roots with Henry Louis Gates, Jr. (2012) that his great-grandfather, who was from Brazavas, Kalvarija, Lithuania, had changed his surname from Trakianski to Meyers, after his own father, Mejer Trakianski.
- Ashe Olsen Meyers, son with wife Alexi Ashe Meyers, was born on March 27, 2016. He came two weeks early. Ashe is his wife's and Olsen his mother's maiden name.
- One of Time magazine's 100 Most Influential People in the World. (April 2014)
- Though he's from New England, his favorite football team is the Pittsburgh Steelers, not the New England Patriots. His father is from Pennsylvania.
- Is a Democrat.
- Did the introduction for WMUR's Friday Night Football broadcast on September 24, 2004.
- Son of Larry Meyers and Hilary Meyers.
- Son-in-law of Tom Ashe and Joanne Ashe.
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