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Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Molecular Subtypes

MedGen UID:
1665285
•Concept ID:
C4725000
•
Neoplastic Process
Synonyms: Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Genetic Subtypes; DLBCL, NOS Genetic Subtypes; DLBCL, NOS Molecular Subtypes

Definition

Molecular subtyping of diffuse large B-cell lymphomas (DLBCL) based on structural genomic abnormalities and gene expression data obtained from biopsy samples. The molecular analysis revealed four subtypes of DLBCL (MCD, BN2, N1, and EZB) which have distinct genotypic, epigenetic, and clinical characteristics. (NEJM 2018; 378: 1396-407) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiffuse Large B-Cell Lymphoma, Not Otherwise Specified Molecular Subtypes

Professional guidelines

PubMed

Navigating the Evolving Treatment Landscape of Diffuse Large B-Cell Lymphoma.
Nastoupil LJ, Bartlett NL
J Clin Oncol 2023 Feb 1;41(4):903-913. Epub 2022 Dec 12 doi: 10.1200/JCO.22.01848. PMID: 36508700
Treatment strategies for patients with diffuse large B-cell lymphoma.
Poletto S, Novo M, Paruzzo L, Frascione PMM, Vitolo U
Cancer Treat Rev 2022 Nov;110:102443. Epub 2022 Jul 31 doi: 10.1016/j.ctrv.2022.102443. PMID: 35933930
MALT lymphoma: epidemiology, clinical diagnosis and treatment.
Violeta Filip P, Cuciureanu D, Sorina Diaconu L, Maria Vladareanu A, Silvia Pop C
J Med Life 2018 Jul-Sep;11(3):187-193. doi: 10.25122/jml-2018-0035. PMID: 30364585Free PMC Article

Recent clinical studies

Etiology

Clinicopathological, cytogenetic, and molecular profiles of primary cutaneous diffuse large B-cell lymphomas.
Uccella S, Goteri G, Maiorana A, Donati V, Tibiletti MG, Magnoli F, Facchi S, Merchiori D, Morsia E, Papotti R, Bettelli S, Forti E, Galimberti S, Rupoli S, Filosa A, Dardanis D, Bomben R, Braglia L, Pozzi S, Sacchi S
Hum Pathol 2023 Jun;136:44-55. Epub 2023 Mar 28 doi: 10.1016/j.humpath.2023.03.012. PMID: 36997030
Diffuse large B-cell lymphomas, not otherwise specified, and emerging entities.
Song JY, Dirnhofer S, Piris MA, Quintanilla-Martínez L, Pileri S, Campo E
Virchows Arch 2023 Jan;482(1):179-192. Epub 2022 Dec 2 doi: 10.1007/s00428-022-03466-6. PMID: 36459219
Double expressor and double/triple hit status among primary cutaneous diffuse large B-cell lymphoma: a comparison between leg type and not otherwise specified subtypes.
Lucioni M, Pescia C, Bonometti A, Fraticelli S, Moltrasio C, Ramponi A, Riboni R, Roccio S, Ferrario G, Arcaini L, Goteri G, Berti E, Paulli M
Hum Pathol 2021 May;111:1-9. Epub 2021 Feb 3 doi: 10.1016/j.humpath.2021.01.006. PMID: 33548250
Distinct molecular profile of IRF4-rearranged large B-cell lymphoma.
Ramis-Zaldivar JE, Gonzalez-Farré B, Balagué O, Celis V, Nadeu F, Salmerón-Villalobos J, Andrés M, Martin-Guerrero I, Garrido-Pontnou M, Gaafar A, Suñol M, Bárcena C, Garcia-Bragado F, Andión M, Azorín D, Astigarraga I, Sagaseta de Ilurdoz M, Sábado C, Gallego S, Verdú-Amorós J, Fernandez-Delgado R, Perez V, Tapia G, Mozos A, Torrent M, Solano-Páez P, Rivas-Delgado A, Dlouhy I, Clot G, Enjuanes A, López-Guillermo A, Galera P, Oberley MJ, Maguire A, Ramsower C, Rimsza LM, Quintanilla-Martinez L, Jaffe ES, Campo E, Salaverria I
Blood 2020 Jan 23;135(4):274-286. doi: 10.1182/blood.2019002699. PMID: 31738823Free PMC Article
Diffuse large B-cell lymphoma.
Li S, Young KH, Medeiros LJ
Pathology 2018 Jan;50(1):74-87. Epub 2017 Nov 20 doi: 10.1016/j.pathol.2017.09.006. PMID: 29167021

Diagnosis

Clinicopathological, cytogenetic, and molecular profiles of primary cutaneous diffuse large B-cell lymphomas.
Uccella S, Goteri G, Maiorana A, Donati V, Tibiletti MG, Magnoli F, Facchi S, Merchiori D, Morsia E, Papotti R, Bettelli S, Forti E, Galimberti S, Rupoli S, Filosa A, Dardanis D, Bomben R, Braglia L, Pozzi S, Sacchi S
Hum Pathol 2023 Jun;136:44-55. Epub 2023 Mar 28 doi: 10.1016/j.humpath.2023.03.012. PMID: 36997030
CD56-positive diffuse large B-cell lymphoma: comprehensive analysis of clinical, pathological, and molecular characteristics with literature review.
Gasljevic G, Boltezar L, Novakovic S, Setrajcic-Dragos V, Jezersek-Novakovic B, Kloboves-Prevodnik V
Radiol Oncol 2023 Jun 1;57(2):249-256. Epub 2023 Mar 21 doi: 10.2478/raon-2023-0016. PMID: 36942468Free PMC Article
Defining and treating high-grade B-cell lymphoma, NOS.
Olszewski AJ, Kurt H, Evens AM
Blood 2022 Sep 1;140(9):943-954. doi: 10.1182/blood.2020008374. PMID: 34525177
Distinct molecular profile of IRF4-rearranged large B-cell lymphoma.
Ramis-Zaldivar JE, Gonzalez-Farré B, Balagué O, Celis V, Nadeu F, Salmerón-Villalobos J, Andrés M, Martin-Guerrero I, Garrido-Pontnou M, Gaafar A, Suñol M, Bárcena C, Garcia-Bragado F, Andión M, Azorín D, Astigarraga I, Sagaseta de Ilurdoz M, Sábado C, Gallego S, Verdú-Amorós J, Fernandez-Delgado R, Perez V, Tapia G, Mozos A, Torrent M, Solano-Páez P, Rivas-Delgado A, Dlouhy I, Clot G, Enjuanes A, López-Guillermo A, Galera P, Oberley MJ, Maguire A, Ramsower C, Rimsza LM, Quintanilla-Martinez L, Jaffe ES, Campo E, Salaverria I
Blood 2020 Jan 23;135(4):274-286. doi: 10.1182/blood.2019002699. PMID: 31738823Free PMC Article
Diffuse large B-cell lymphoma.
Li S, Young KH, Medeiros LJ
Pathology 2018 Jan;50(1):74-87. Epub 2017 Nov 20 doi: 10.1016/j.pathol.2017.09.006. PMID: 29167021

Therapy

Diffuse large B cell lymphoma: using pathologic and molecular biomarkers to define subgroups for novel therapy.
Carbone A, Gloghini A, Kwong YL, Younes A
Ann Hematol 2014 Aug;93(8):1263-77. Epub 2014 May 29 doi: 10.1007/s00277-014-2116-y. PMID: 24870942Free PMC Article

Prognosis

Clinicopathological, cytogenetic, and molecular profiles of primary cutaneous diffuse large B-cell lymphomas.
Uccella S, Goteri G, Maiorana A, Donati V, Tibiletti MG, Magnoli F, Facchi S, Merchiori D, Morsia E, Papotti R, Bettelli S, Forti E, Galimberti S, Rupoli S, Filosa A, Dardanis D, Bomben R, Braglia L, Pozzi S, Sacchi S
Hum Pathol 2023 Jun;136:44-55. Epub 2023 Mar 28 doi: 10.1016/j.humpath.2023.03.012. PMID: 36997030
CD56-positive diffuse large B-cell lymphoma: comprehensive analysis of clinical, pathological, and molecular characteristics with literature review.
Gasljevic G, Boltezar L, Novakovic S, Setrajcic-Dragos V, Jezersek-Novakovic B, Kloboves-Prevodnik V
Radiol Oncol 2023 Jun 1;57(2):249-256. Epub 2023 Mar 21 doi: 10.2478/raon-2023-0016. PMID: 36942468Free PMC Article
Defining and treating high-grade B-cell lymphoma, NOS.
Olszewski AJ, Kurt H, Evens AM
Blood 2022 Sep 1;140(9):943-954. doi: 10.1182/blood.2020008374. PMID: 34525177
Distinct molecular profile of IRF4-rearranged large B-cell lymphoma.
Ramis-Zaldivar JE, Gonzalez-Farré B, Balagué O, Celis V, Nadeu F, Salmerón-Villalobos J, Andrés M, Martin-Guerrero I, Garrido-Pontnou M, Gaafar A, Suñol M, Bárcena C, Garcia-Bragado F, Andión M, Azorín D, Astigarraga I, Sagaseta de Ilurdoz M, Sábado C, Gallego S, Verdú-Amorós J, Fernandez-Delgado R, Perez V, Tapia G, Mozos A, Torrent M, Solano-Páez P, Rivas-Delgado A, Dlouhy I, Clot G, Enjuanes A, López-Guillermo A, Galera P, Oberley MJ, Maguire A, Ramsower C, Rimsza LM, Quintanilla-Martinez L, Jaffe ES, Campo E, Salaverria I
Blood 2020 Jan 23;135(4):274-286. doi: 10.1182/blood.2019002699. PMID: 31738823Free PMC Article
Diffuse large B-cell lymphoma.
Li S, Young KH, Medeiros LJ
Pathology 2018 Jan;50(1):74-87. Epub 2017 Nov 20 doi: 10.1016/j.pathol.2017.09.006. PMID: 29167021

Clinical prediction guides

Differences in mutational signature of diffuse large B-cell lymphomas according to the primary organ.
Koh HH, Yoon SE, Kim SJ, Kim WS, Cho J
Cancer Med 2023 Oct;12(19):19732-19743. Epub 2023 Sep 14 doi: 10.1002/cam4.6533. PMID: 37706649Free PMC Article
CD56-positive diffuse large B-cell lymphoma: comprehensive analysis of clinical, pathological, and molecular characteristics with literature review.
Gasljevic G, Boltezar L, Novakovic S, Setrajcic-Dragos V, Jezersek-Novakovic B, Kloboves-Prevodnik V
Radiol Oncol 2023 Jun 1;57(2):249-256. Epub 2023 Mar 21 doi: 10.2478/raon-2023-0016. PMID: 36942468Free PMC Article
Double expressor and double/triple hit status among primary cutaneous diffuse large B-cell lymphoma: a comparison between leg type and not otherwise specified subtypes.
Lucioni M, Pescia C, Bonometti A, Fraticelli S, Moltrasio C, Ramponi A, Riboni R, Roccio S, Ferrario G, Arcaini L, Goteri G, Berti E, Paulli M
Hum Pathol 2021 May;111:1-9. Epub 2021 Feb 3 doi: 10.1016/j.humpath.2021.01.006. PMID: 33548250
Diffuse large B-cell lymphoma.
Li S, Young KH, Medeiros LJ
Pathology 2018 Jan;50(1):74-87. Epub 2017 Nov 20 doi: 10.1016/j.pathol.2017.09.006. PMID: 29167021
Diffuse large B cell lymphoma: using pathologic and molecular biomarkers to define subgroups for novel therapy.
Carbone A, Gloghini A, Kwong YL, Younes A
Ann Hematol 2014 Aug;93(8):1263-77. Epub 2014 May 29 doi: 10.1007/s00277-014-2116-y. PMID: 24870942Free PMC Article

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