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Fibrosis of the skin

MedGen UID:
537541
•Concept ID:
C0263008
•
Disease or Syndrome
Synonym: Dermal fibrosis
SNOMED CT: Fibrosis of skin (74853008); Fibrosis of the skin (74853008); Fibrotic disorder of skin (74853008)

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFibrosis of the skin

Professional guidelines

PubMed

Clinical Treatment Options in Scleroderma: Recommendations and Comprehensive Review.
Zhao M, Wu J, Wu H, Sawalha AH, Lu Q
Clin Rev Allergy Immunol 2022 Apr;62(2):273-291. Epub 2021 Jan 15 doi: 10.1007/s12016-020-08831-4. PMID: 33449302
Scleroderma of the Hand: Evaluation and Treatment.
Beldner S, Rabinovich RV, Polatsch DB
J Am Acad Orthop Surg 2020 Aug 15;28(16):e686-e695. doi: 10.5435/JAAOS-D-19-00547. PMID: 32769717
Fat Grafting for the Treatment of Scleroderma.
Strong AL, Rubin JP, Kozlow JH, Cederna PS
Plast Reconstr Surg 2019 Dec;144(6):1498-1507. doi: 10.1097/PRS.0000000000006291. PMID: 31764674

Recent clinical studies

Etiology

Scleroderma epidemiology update.
Calderon LM, Pope JE
Curr Opin Rheumatol 2021 Mar 1;33(2):122-127. doi: 10.1097/BOR.0000000000000785. PMID: 33481429
Scleroderma of the Hand: Evaluation and Treatment.
Beldner S, Rabinovich RV, Polatsch DB
J Am Acad Orthop Surg 2020 Aug 15;28(16):e686-e695. doi: 10.5435/JAAOS-D-19-00547. PMID: 32769717
Systemic sclerosis.
Allanore Y, Simms R, Distler O, Trojanowska M, Pope J, Denton CP, Varga J
Nat Rev Dis Primers 2015 Apr 23;1:15002. doi: 10.1038/nrdp.2015.2. PMID: 27189141
Adjuvant lymph-node field radiotherapy versus observation only in patients with melanoma at high risk of further lymph-node field relapse after lymphadenectomy (ANZMTG 01.02/TROG 02.01): 6-year follow-up of a phase 3, randomised controlled trial.
Henderson MA, Burmeister BH, Ainslie J, Fisher R, Di Iulio J, Smithers BM, Hong A, Shannon K, Scolyer RA, Carruthers S, Coventry BJ, Babington S, Duprat J, Hoekstra HJ, Thompson JF
Lancet Oncol 2015 Sep;16(9):1049-1060. Epub 2015 Jul 20 doi: 10.1016/S1470-2045(15)00187-4. PMID: 26206146
The role of leukotrienes in the pathogenesis of systemic sclerosis.
Chwieśko-Minarowska S, Kowal K, Bielecki M, Kowal-Bielecka O
Folia Histochem Cytobiol 2012 Jul 5;50(2):180-5. doi: 10.5603/fhc.2012.0027. PMID: 22763975

Diagnosis

Role of imaging in morphea assessment: A review of the literature.
Khorasanizadeh F, Kalantari Y, Etesami I
Skin Res Technol 2023 Jul;29(7):e13410. doi: 10.1111/srt.13410. PMID: 37522502Free PMC Article
Scleroderma of the Hand: Evaluation and Treatment.
Beldner S, Rabinovich RV, Polatsch DB
J Am Acad Orthop Surg 2020 Aug 15;28(16):e686-e695. doi: 10.5435/JAAOS-D-19-00547. PMID: 32769717
Gender-related differences in systemic sclerosis.
Hughes M, Pauling JD, Armstrong-James L, Denton CP, Galdas P, Flurey C
Autoimmun Rev 2020 Apr;19(4):102494. Epub 2020 Feb 13 doi: 10.1016/j.autrev.2020.102494. PMID: 32062031
Systemic sclerosis.
Denton CP, Khanna D
Lancet 2017 Oct 7;390(10103):1685-1699. Epub 2017 Apr 13 doi: 10.1016/S0140-6736(17)30933-9. PMID: 28413064
Systemic sclerosis.
Allanore Y, Simms R, Distler O, Trojanowska M, Pope J, Denton CP, Varga J
Nat Rev Dis Primers 2015 Apr 23;1:15002. doi: 10.1038/nrdp.2015.2. PMID: 27189141

Therapy

Tofacitinib blocks IFN-regulated biomarker genes in skin fibroblasts and keratinocytes in a systemic sclerosis trial.
Khanna D, Padilla C, Tsoi LC, Nagaraja V, Khanna PP, Tabib T, Kahlenberg JM, Young A, Huang S, Gudjonsson JE, Fox DA, Lafyatis R
JCI Insight 2022 Sep 8;7(17) doi: 10.1172/jci.insight.159566. PMID: 35943798Free PMC Article
Clinical Treatment Options in Scleroderma: Recommendations and Comprehensive Review.
Zhao M, Wu J, Wu H, Sawalha AH, Lu Q
Clin Rev Allergy Immunol 2022 Apr;62(2):273-291. Epub 2021 Jan 15 doi: 10.1007/s12016-020-08831-4. PMID: 33449302
Scleroderma epidemiology update.
Calderon LM, Pope JE
Curr Opin Rheumatol 2021 Mar 1;33(2):122-127. doi: 10.1097/BOR.0000000000000785. PMID: 33481429
Experimental Mouse Model of Bleomycin-Induced Skin Fibrosis.
Błyszczuk P, Kozlova A, Guo Z, Kania G, Distler O
Curr Protoc Immunol 2019 Sep;126(1):e88. doi: 10.1002/cpim.88. PMID: 31483105
Systemic sclerosis.
Asano Y
J Dermatol 2018 Feb;45(2):128-138. Epub 2017 Dec 10 doi: 10.1111/1346-8138.14153. PMID: 29226387

Prognosis

Scleroderma epidemiology update.
Calderon LM, Pope JE
Curr Opin Rheumatol 2021 Mar 1;33(2):122-127. doi: 10.1097/BOR.0000000000000785. PMID: 33481429
Fat Grafting for the Treatment of Scleroderma.
Strong AL, Rubin JP, Kozlow JH, Cederna PS
Plast Reconstr Surg 2019 Dec;144(6):1498-1507. doi: 10.1097/PRS.0000000000006291. PMID: 31764674
Genetic implications in the pathogenesis of systemic sclerosis.
Rezaei R, Aslani S, Dashti N, Jamshidi A, Gharibdoost F, Mahmoudi M
Int J Rheum Dis 2018 Aug;21(8):1478-1486. doi: 10.1111/1756-185X.13344. PMID: 30146749
Systemic sclerosis.
Allanore Y, Simms R, Distler O, Trojanowska M, Pope J, Denton CP, Varga J
Nat Rev Dis Primers 2015 Apr 23;1:15002. doi: 10.1038/nrdp.2015.2. PMID: 27189141
Adjuvant lymph-node field radiotherapy versus observation only in patients with melanoma at high risk of further lymph-node field relapse after lymphadenectomy (ANZMTG 01.02/TROG 02.01): 6-year follow-up of a phase 3, randomised controlled trial.
Henderson MA, Burmeister BH, Ainslie J, Fisher R, Di Iulio J, Smithers BM, Hong A, Shannon K, Scolyer RA, Carruthers S, Coventry BJ, Babington S, Duprat J, Hoekstra HJ, Thompson JF
Lancet Oncol 2015 Sep;16(9):1049-1060. Epub 2015 Jul 20 doi: 10.1016/S1470-2045(15)00187-4. PMID: 26206146

Clinical prediction guides

CXCL9 Links Skin Inflammation and Fibrosis through CXCR3-Dependent Upregulation of Col1a1 in Fibroblasts.
Richmond JM, Patel D, Watanabe T, Chen HW, Martyanov V, Werner G, Garg M, Haddadi NS, Refat MA, Mahmoud BH, Wong LD, Dresser K, Deng A, Zhu JL, McAlpine W, Hosler GA, Feghali-Bostwick CA, Whitfield ML, Harris JE, Torok KS, Jacobe HT
J Invest Dermatol 2023 Jul;143(7):1138-1146.e12. Epub 2023 Jan 25 doi: 10.1016/j.jid.2022.11.025. PMID: 36708947
Tofacitinib blocks IFN-regulated biomarker genes in skin fibroblasts and keratinocytes in a systemic sclerosis trial.
Khanna D, Padilla C, Tsoi LC, Nagaraja V, Khanna PP, Tabib T, Kahlenberg JM, Young A, Huang S, Gudjonsson JE, Fox DA, Lafyatis R
JCI Insight 2022 Sep 8;7(17) doi: 10.1172/jci.insight.159566. PMID: 35943798Free PMC Article
Role of Alarmins in the Pathogenesis of Systemic Sclerosis.
Giovannetti A, Straface E, Rosato E, Casciaro M, Pioggia G, Gangemi S
Int J Mol Sci 2020 Jul 15;21(14) doi: 10.3390/ijms21144985. PMID: 32679721Free PMC Article
Experimental Mouse Model of Bleomycin-Induced Skin Fibrosis.
Błyszczuk P, Kozlova A, Guo Z, Kania G, Distler O
Curr Protoc Immunol 2019 Sep;126(1):e88. doi: 10.1002/cpim.88. PMID: 31483105
Adjuvant lymph-node field radiotherapy versus observation only in patients with melanoma at high risk of further lymph-node field relapse after lymphadenectomy (ANZMTG 01.02/TROG 02.01): 6-year follow-up of a phase 3, randomised controlled trial.
Henderson MA, Burmeister BH, Ainslie J, Fisher R, Di Iulio J, Smithers BM, Hong A, Shannon K, Scolyer RA, Carruthers S, Coventry BJ, Babington S, Duprat J, Hoekstra HJ, Thompson JF
Lancet Oncol 2015 Sep;16(9):1049-1060. Epub 2015 Jul 20 doi: 10.1016/S1470-2045(15)00187-4. PMID: 26206146

Recent systematic reviews

Role of intravenous immunoglobulins in systemic sclerosis (SSc): A systematic literature review.
Koczanowski S, Morrisroe K, Fairley J, Nikpour M, Oon S, Brown Z
Semin Arthritis Rheum 2024 Oct;68:152471. Epub 2024 Jun 22 doi: 10.1016/j.semarthrit.2024.152471. PMID: 38954999
Autologous fat or adipose-derived stem cell grafting in systemic sclerosis treatment: a systematic review and meta-analysis.
Cao Y, Kan H, Ma X, Zhang Y, Huang J, Long X
Clin Exp Rheumatol 2023 Aug;41(8):1659-1669. Epub 2023 Jun 29 doi: 10.55563/clinexprheumatol/ycy3k7. PMID: 37382451
Impact of Innovative Treatment Using Biological Drugs for the Modulation of Diffuse Cutaneous Systemic Sclerosis: A Systematic Review.
Fernández-Lázaro D, Iglesias-Lázaro M, Garrosa E, Rodríguez-García S, Jerves Donoso D, Gutiérrez-Abejón E, Jorge-Finnigan C
Medicina (Kaunas) 2023 Jan 27;59(2) doi: 10.3390/medicina59020247. PMID: 36837449Free PMC Article
Efficacy and safety of mesenchymal stem cells in the treatment of systemic sclerosis: a systematic review and meta-analysis.
Cui J, Jin L, Ding M, He J, Yang L, Cui S, Wang X, Ma J, Liu A
Stem Cell Res Ther 2022 Mar 21;13(1):118. doi: 10.1186/s13287-022-02786-3. PMID: 35313985Free PMC Article
Screening for the early detection of pulmonary arterial hypertension in patients with systemic sclerosis: A systematic review and meta-analysis of long-term outcomes.
Brown Z, Proudman S, Morrisroe K, Stevens W, Hansen D, Nikpour M
Semin Arthritis Rheum 2021 Jun;51(3):495-512. Epub 2021 Apr 4 doi: 10.1016/j.semarthrit.2021.03.011. PMID: 33857705

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