PTPN11

Protein sy'n cael ei godio yn y corff dynol gan y genyn PTPN11 yw PTPN11 a elwir hefyd yn Tyrosine-protein phosphatase non-receptor type 11 a Protein tyrosine phosphatase, non-receptor type 11 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q24.13.

PTPN11
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2SHP, 3B7O, 3MOW, 3O5X, 3TKZ, 3TL0, 4DGP, 4DGX, 4GWF, 4H1O, 4JE4, 4JEG, 3ZM0, 3ZM1, 3ZM2, 3ZM3, 4H34, 4JMG, 4NWF, 4NWG, 4OHD, 4OHE, 4OHH, 4OHI, 4OHL, 4PVG, 4RDD, 4QSY, 5DF6, 5IBS, 5EHP, 5EHR, 5I6V, 5IBM
Dynodwyr
Cyfenwau	PTPN11, BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2, protein tyrosine phosphatase, non-receptor type 11, protein tyrosine phosphatase non-receptor type 11
Dynodwyr allanol	OMIM: 176876 HomoloGene: 2122 GeneCards: PTPN11
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • phospholipase binding • phosphoprotein phosphatase activity • insulin receptor binding • GO:0098519, GO:0098518 phosphatase activity • receptor tyrosine kinase binding • peptide hormone receptor binding • GO:0001948, GO:0016582 protein binding • non-membrane spanning protein tyrosine phosphatase activity • hydrolase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • 1-phosphatidylinositol-3-kinase activity • cell adhesion molecule binding • protein tyrosine phosphatase activity • phosphotyrosine residue binding • protein domain specific binding • D1 dopamine receptor binding • insulin receptor substrate binding • protein tyrosine kinase binding • protein kinase binding Cydrannau o'r gell • cytoplasm • cytosol • mitocondria • cnewyllyn cell • nucleoplasm • GO:0009327 protein-containing complex Prosesau biolegol • GO:0098501, GO:0098502, GO:0006286 dephosphorylation • megakaryocyte development • positive regulation of signal transduction • negative regulation of insulin secretion • regulation of cell adhesion mediated by integrin • atrioventricular canal development • intestinal epithelial cell migration • organ growth • epidermal growth factor receptor signaling pathway • negative regulation of growth hormone secretion • axonogenesis • glucose homeostasis • regulation of protein export from nucleus • multicellular organism growth • regulation of multicellular organism growth • lipid metabolism • ephrin receptor signaling pathway • abortive mitotic cell cycle • DNA damage checkpoint signaling • GO:0016576 protein dephosphorylation • T cell costimulation • platelet formation • microvillus organization • positive regulation of mitotic cell cycle • genitalia development • platelet activation • fibroblast growth factor receptor signaling pathway • heart development • brain development • regulation of type I interferon-mediated signaling pathway • hormone-mediated signaling pathway • integrin-mediated signaling pathway • Bergmann glial cell differentiation • homeostasis of number of cells within a tissue • inner ear development • platelet-derived growth factor receptor signaling pathway • negative regulation of cortisol secretion • peptidyl-tyrosine dephosphorylation • ERBB signaling pathway • negative regulation of hormone secretion • triglyceride metabolic process • hormone metabolic process • positive regulation of hormone secretion • negative regulation of cell adhesion mediated by integrin • GO:0106159 regulation of protein-containing complex assembly • face morphogenesis • cerebellar cortex formation • leukocyte migration • multicellular organismal reproductive process • phosphatidylinositol phosphate biosynthetic process • neurotrophin TRK receptor signaling pathway • phosphatidylinositol-3-phosphate biosynthetic process • axon guidance • positive regulation of ERK1 and ERK2 cascade • cellular response to epidermal growth factor stimulus • positive regulation of protein kinase B signaling • cytokine-mediated signaling pathway • interleukin-6-mediated signaling pathway • cellular response to cytokine stimulus • cellular response to mechanical stimulus • positive regulation of interferon-beta production • positive regulation of interleukin-6 production • positive regulation of tumor necrosis factor production • positive regulation of glucose import • GO:1903106 positive regulation of insulin receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5781	n/a
Ensembl	ENSG00000179295	n/a
UniProt	Q06124	n/a
RefSeq (mRNA)	NM_002834 NM_080601 NM_001330437 NM_001374625 NM_018508	n/a
RefSeq (protein)	NP_001317366 NP_002825 NP_542168 NP_001361554	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PTPN11.

• CFC
• NS1
• JMML
• SHP2
• BPTP3
• PTP2C
• METCDS
• PTP-1D
• SH-PTP2
• SH-PTP3

Llyfryddiaeth

• "Hotspots in PTPN11 Gene Among Indian Children With Noonan Syndrome. ". Indian Pediatr. 2017. PMID 28607217.
• "Cochlear implantation and clinical features in patients with Noonan syndrome and Noonan syndrome with multiple lentigines caused by a mutation in PTPN11. ". Int J Pediatr Otorhinolaryngol. 2017. PMID 28483241.
• "Noonan syndrome, PTPN11 mutations, and brain tumors. A clinical report and review of the literature. ". Am J Med Genet A. 2017. PMID 28328117.
• "Shp2 Plays a Critical Role in IL-6-Induced EMT in Breast Cancer Cells. ". Int J Mol Sci. 2017. PMID 28208810.
• "Melanoma exosomes deliver a complex biological payload that upregulates PTPN11 to suppress T lymphocyte function.". Pigment Cell Melanoma Res. 2017. PMID 27930879.