HUS1

HUS1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3A1J, 3G65, 3GGR
Dynodwyr
Cyfenwau	HUS1, hHUS1 checkpoint clamp component
Dynodwyr allanol	OMIM: 603760 HomoloGene: 37932 GeneCards: HUS1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • site of double-strand break • cytoplasm • cytosol • nucleoplasm • checkpoint clamp complex • nucleolus • cnewyllyn cell Prosesau biolegol • regulation of protein phosphorylation • nucleotide-excision repair • meiotic DNA integrity checkpoint signaling • embryo development • mitotic cell cycle checkpoint signaling • mitotic intra-S DNA damage checkpoint signaling • negative regulation of DNA replication • cellular response to DNA damage stimulus • protein phosphorylation • mitotic DNA replication checkpoint signaling • cellular response to ionizing radiation • response to UV • double-strand break repair via homologous recombination • DNA damage checkpoint signaling • GO:0100026 DNA repair • embryo development ending in birth or egg hatching • telomere maintenance • DNA replication • regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3364	n/a
Ensembl	ENSG00000136273	n/a
UniProt	O60921	n/a
RefSeq (mRNA)	NM_004507 NM_001363683	n/a
RefSeq (protein)	NP_004498 NP_001350612	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HUS1 yw HUS1 a elwir hefyd yn Checkpoint protein HUS1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7p12.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HUS1.

• hHUS1

Llyfryddiaeth

• "Downregulation of Hus1 by antisense oligonucleotides enhances the sensitivity of human lung carcinoma cells to cisplatin. ". Cancer. 2002. PMID 11920544.
• "The Roles of p21(Waf1/CIP1) and Hus1 in Generation and Transmission of Damage Signals Stimulated by Low-Dose Alpha-Particle Irradiation. ". Radiat Res. 2015. PMID 26600172.
• "Genome Protection by the 9-1-1 Complex Subunit HUS1 Requires Clamp Formation, DNA Contacts, and ATR Signaling-independent Effector Functions. ". J Biol Chem. 2015. PMID 25911100.
• "Low penetrance alleles as risk modifiers in familial and sporadic breast cancer. ". Fam Cancer. 2012. PMID 22926736.
• "Expression of DNA damage checkpoint protein Hus1 in epithelial ovarian tumors correlates with prognostic markers.". Int J Gynecol Pathol. 2008. PMID 18156970.