NTRK1

NTRK1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1HE7, 1SHC, 1WWA, 1WWW, 2IFG, 4AOJ, 4F0I, 4GT5, 4CRP, 4PMM, 4PMP, 4PMS, 4PMT, 4YNE, 4YPS
Dynodwyr
Cyfenwau	NTRK1, MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA, neurotrophic receptor tyrosine kinase 1
Dynodwyr allanol	OMIM: 191315 HomoloGene: 1898 GeneCards: NTRK1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • neurotrophin binding • GPI-linked ephrin receptor activity • neurotrophin receptor activity • kinase activity • ATP binding • protein kinase activity • kinase binding • transferase activity • protein homodimerization activity • GO:0001948, GO:0016582 protein binding • nucleotide binding • nerve growth factor binding • neurotrophin p75 receptor binding • protein tyrosine kinase activity • transmembrane receptor protein tyrosine kinase activity • nerve growth factor receptor activity Cydrannau o'r gell • cytoplasm • endosome • bilen • late endosome membrane • cell surface • integral component of membrane • late endosome • early endosome membrane • receptor complex • Cellbilen • axon • soma • early endosome • integral component of plasma membrane • dendrite • GO:0016023 cytoplasmic vesicle • Golgi membrane • endosome membrane • GO:0009327 protein-containing complex • recycling endosome • recycling endosome membrane Prosesau biolegol • GO:1904089 negative regulation of neuron apoptotic process • positive regulation of protein phosphorylation • positive regulation of Ras protein signal transduction • positive regulation of programmed cell death • behavioral response to formalin induced pain • detection of temperature stimulus involved in sensory perception of pain • protein phosphorylation • Rhythm circadaidd • positive regulation of ERK1 and ERK2 cascade • B cell differentiation • response to ethanol • innervation • negative regulation of cell population proliferation • response to nicotine • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • positive regulation of synaptic transmission, glutamatergic • response to nutrient levels • learning or memory • protein autophosphorylation • negative regulation of neuron death • detection of mechanical stimulus involved in sensory perception of pain • cell differentiation • neurotrophin TRK receptor signaling pathway • phosphorylation • cellular response to nicotine • olfactory nerve development • response to electrical stimulus • Sertoli cell development • mechanoreceptor differentiation • nervous system development • positive regulation of angiogenesis • positive regulation of NF-kappaB transcription factor activity • response to axon injury • sensory perception of pain • response to radiation • phosphatidylinositol-mediated signaling • sympathetic nervous system development • ephrin receptor signaling pathway • cellular response to growth factor stimulus • GO:0010260 heneiddio • response to hydrostatic pressure • response to activity • axon guidance • multicellular organism development • axonogenesis involved in innervation • positive regulation of neuron projection development • programmed cell death involved in cell development • positive regulation of synapse assembly • transmembrane receptor protein tyrosine kinase signaling pathway • microtubule-based movement • peptidyl-tyrosine phosphorylation • peptidyl-tyrosine autophosphorylation • nerve growth factor signaling pathway • cellular response to nerve growth factor stimulus • positive regulation of phosphatidylinositol 3-kinase signaling • negative regulation of apoptotic process • regulation of MAPK cascade • positive regulation of MAPK cascade • cellular response to amyloid-beta Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4914	n/a
Ensembl	ENSG00000198400	n/a
UniProt	P04629	n/a
RefSeq (mRNA)	NM_002529 NM_001007792 NM_001012331	n/a
RefSeq (protein)	NP_001007793 NP_001012331 NP_002520	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NTRK1 yw NTRK1 a elwir hefyd yn Neurotrophic receptor tyrosine kinase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q23.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NTRK1.

• MTC
• TRK
• TRK1
• TRKA
• Trk-A
• p140-TrkA

Llyfryddiaeth

• "Identification of a novel nonsense mutation of the neurotrophic tyrosine kinase receptor type 1 gene in two siblings with congenital insensitivity to pain with anhidrosis. ". J Int Med Res. 2017. PMID 28345382.
• "Exome sequencing identifies novel NTRK1 mutations in patients with HSAN-IV phenotype. ". Am J Med Genet A. 2017. PMID 28328124.
• "Recurrent NTRK1 Gene Fusions Define a Novel Subset of Locally Aggressive Lipofibromatosis-like Neural Tumors. ". Am J Surg Pathol. 2016. PMID 27259011.
• "Whole exome sequencing in congenital pain insensitivity identifies a novel causative intronic NTRK1-mutation due to uniparental disomy. ". Am J Med Genet B Neuropsychiatr Genet. 2016. PMID 27184211.
• "Paediatric and adult soft tissue sarcomas with NTRK1 gene fusions: a subset of spindle cell sarcomas unified by a prominent myopericytic/haemangiopericytic pattern.". J Pathol. 2016. PMID 26863915.