PDE10A

PDE10A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2OUN, 2OUP, 2OUQ, 2OUR, 2OUS, 2OUU, 2OUV, 2OUY, 2WEY, 2Y0J, 2ZMF, 3SN7, 3SNI, 3SNL, 3UI7, 3UUO, 3WI2, 3WS8, 3WS9, 3WYK, 3WYL, 3WYM, 4AEL, 4AJD, 4AJF, 4AJG, 4AJM, 4BBX, 4DDL, 4DFF, 4FCB, 4FCD, 4HEU, 4HF4, 4LKQ, 4LLJ, 4LLK, 4LLP, 4LLX, 4LM0, 4LM1, 4LM2, 4LM3, 4LM4, 4MRW, 4MRZ, 4MS0, 4MSA, 4MSC, 4MSE, 4MSH, 4MSN, 4MUW, 4MVH, 4P0N, 4P1R, 4PHW, 4TPM, 4TPP, 4WN1, 4XY2, 4YQH, 4YS7, 4ZO5, 5C1W, 5C28, 5C29, 5C2A, 5C2H, 5DH5, 5AXQ, 5DH4, 5AXP, 5C2E, 5EDH, 5EDI, 5EDG, 5EDE, 5I2R, 5B4L, 5B4K
Dynodwyr
Cyfenwau	PDE10A, HSPDE10A19, ADSD2, IOLOD, phosphodiesterase 10A, LINC00473
Dynodwyr allanol	OMIM: 610652 HomoloGene: 4852 GeneCards: PDE10A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • 3',5'-cyclic-nucleotide phosphodiesterase activity • cAMP binding • cGMP binding • metal ion binding • cGMP-stimulated cyclic-nucleotide phosphodiesterase activity • cyclic-nucleotide phosphodiesterase activity • catalytic activity • phosphoric diester hydrolase activity • hydrolase activity • 3',5'-cyclic-AMP phosphodiesterase activity • 3',5'-cyclic-GMP phosphodiesterase activity Cydrannau o'r gell • cytoplasm • cytosol • perikaryon • bilen • soma Prosesau biolegol • cAMP catabolic process • regulation of protein kinase A signaling • cGMP catabolic process • regulation of cAMP-mediated signaling • metabolaeth • GO:0072468 signal transduction • G protein-coupled receptor signaling pathway • negative regulation of cGMP-mediated signaling • negative regulation of cAMP-mediated signaling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10846	n/a
Ensembl	ENSG00000112541	n/a
UniProt	Q9Y233	n/a
RefSeq (mRNA)	NM_001130690 NM_006661 NM_001385079	n/a
RefSeq (protein)	NP_001124162 NP_006652	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PDE10A yw PDE10A a elwir hefyd yn Phosphodiesterase 10A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6q27.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PDE10A.

• ADSD2
• IOLOD
• HSPDE10A
• PDE10A19
• LINC00473

Llyfryddiaeth

• "De Novo Mutations in PDE10A Cause Childhood-Onset Chorea with Bilateral Striatal Lesions. ". Am J Hum Genet. 2016. PMID 27058447.
• "Novel, primate-specific PDE10A isoform highlights gene expression complexity in human striatum with implications on the molecular pathology of bipolar disorder. ". Transl Psychiatry. 2016. PMID 26905414.
• "Novel PDE10A transcript diversity in the human striatum: Insights into gene complexity, conservation and regulation. ". Gene. 2017. PMID 28042091.
• "Characterization of [11C]Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brain. ". Eur J Nucl Med Mol Imaging. 2017. PMID 27817159.
• "A novel thermoregulatory role for PDE10A in mouse and human adipocytes.". EMBO Mol Med. 2016. PMID 27247380.