PKNOX1

PKNOX1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1X2N
Dynodwyr
Cyfenwau	PKNOX1, PREP1, pkonx1c, PBX/knotted 1 homeobox 1
Dynodwyr allanol	OMIM: 602100 HomoloGene: 3363 GeneCards: PKNOX1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • sequence-specific DNA binding • DNA binding • protein heterodimerization activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cytoplasm • cnewyllyn cell • transcription regulator complex • cytosol Prosesau biolegol • erythrocyte differentiation • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • camera-type eye development • T cell differentiation • GO:0009373 regulation of transcription, DNA-templated • angiogenesis • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • hemopoiesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5316	n/a
Ensembl	ENSG00000160199	n/a
UniProt	P55347 Q96I87	n/a
RefSeq (mRNA)	NM_001286258 NM_004571 NM_001320694 NM_197976	n/a
RefSeq (protein)	NP_001273187 NP_001307623 NP_004562 NP_001273187.1 NP_004562.2 NP_001307623.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PKNOX1 yw PKNOX1 a elwir hefyd yn PBX/knotted 1 homeobox 1 a Homeobox-containing protein PKNOX1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 21, band 21q22.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PKNOX1.

• PREP1
• pkonx1c

Llyfryddiaeth

• "Homeodomain transcription factor and tumor suppressor Prep1 is required to maintain genomic stability. ". Proc Natl Acad Sci U S A. 2011. PMID 21715654.
• "Prep1 (pKnox1)-deficiency leads to spontaneous tumor development in mice and accelerates EmuMyc lymphomagenesis: a tumor suppressor role for Prep1. ". Mol Oncol. 2010. PMID 20106730.
• "Single nucleotide polymorphism in gene encoding transcription factor Prep1 is associated with HIV-1-associated dementia. ". PLoS One. 2012. PMID 22347417.
• "[Molecular cloning for an alternatively splicing cDNA of human PKNOX1 gene and it's expression analysis]. ". Yi Chuan Xue Bao. 2004. PMID 15468914.
• "Cloning of a novel homeobox-containing gene, PKNOX1, and mapping to human chromosome 21q22.3.". Genomics. 1997. PMID 9143494.