Talk:Interleukin-1 family

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Signaling

The second paragraph here is difficult to follow and inconsistent (maybe because a different pathway is being described here) than the MYD88 wiki. I think a figure here showing a pictorial representation would be really helpful. Neuroschizl (talk) 21:34, 30 January 2015 (UTC)[reply]

IL-18 location

Just a note - I've changed location of IL-18 back to chromosome 11 according to original source. Refseq database also supports this (Gene ID: 3606) http://www.ncbi.nlm.nih.gov/gene?LinkName=nuccore_gene&from_uid=323510659. --Faskal (talk) 08:57, 4 August 2013 (UTC)[reply]

Health caim about obesity

Hi, @Jytdog:.

I just read part of Wikipedia:Identifying reliable sources (medicine) and agree that the second claim may not be permited. But this review (a secondary source?) said: "Obesity is characterized by increased levels of circulating proinflammatory cytokines [including interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and IL-6], accumulation of leukocytes within the adipose tissue and other organs, activation of macrophages in the liver and fat, and activation of proinflammatory signaling pathways in multiple organs (43, 44)." So is that permited?

Your reply will be appreciated. --The Master (talk) 15:31, 5 December 2014 (UTC)[reply]

Thank you for talking! Please read all of MEDRS. and please also read WP:MEDMOS. We don't make absolute claims about health based on animal or in vitro studies, as you did, nor based on the conclusions of primary sources. And what you wrote was "IL1β... can cause cognitive deficits" which is wildly different from what the frontiers source says. Also please cite the PMID in the reference (frontiers source is PMID 24860551). And please back way off the certainty with which you are stating causality. The frontiers source is very clear in saying "The directionality of the relationship between obesity and neuropsychiatric symptoms is usually difficult to determine from clinical studies." The right way to generate content is to read the most recent secondary sources you can on the topic (in this case, what you appear to be interested in is the intersection of IL1, obesity, and neuropsychiatric symptoms in human health) and carefully summarize what those sources say. Avoid getting highly technical (see WP:TECHNICAL) without laying the groundwork; WP is an encyclopedia for the general public. Jytdog (talk) 15:52, 5 December 2014 (UTC)[reply]

Thank you for the insperation! I will learn more before adding more content to this article.--The Master (talk) 16:02, 5 December 2014 (UTC)[reply]

The citation:

Castanon N, Lasselin J, Capuron L (2014). "Neuropsychiatric comorbidity in obesity: role of inflammatory processes". Front Endocrinol (Lausanne). 5: 74. doi:10.3389/fendo.2014.00074. PMC 4030152. PMID 24860551.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)

according to PubMed is secondary, however it only mentions interleukin-1β in passing. It would be permissible to state something like "Increased levels of interleukin-1β are observed in obesity". Boghog (talk) 15:59, 5 December 2014 (UTC)[reply]

OK.--The Master (talk) 16:02, 5 December 2014 (UTC)[reply]

yes the frontiers source is secondary; the only good one. thanks for clarifying that boghog I should have been more clear. it was however wrongly used. Jytdog (talk) 16:03, 5 December 2014 (UTC)[reply]

Family / superfamily

What's the diference between family and superfamily here? It's a bit confusing. The text says the family has 11 members but also the superfamily has 11 members.--Miguelferig (talk) 17:12, 1 April 2019 (UTC)[reply]