Etofenamate: Difference between revisions
Content deleted Content added
Updating {{drugbox}} (changes to watched fields - added verified revid - updated 'ChEMBL_Ref', 'ChEBI_Ref', 'ChEBI_Ref') per Chem/Drugbox validation (report errors or [[user talk:CheMoBot|b |
Changing short description from "Chemical compound" to "NSAID analgesic medication" |
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{{Short description|NSAID analgesic medication}} |
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{{Drugbox |
{{Drugbox |
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| ⚫ | |||
| Watchedfields = changed |
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| ⚫ | |||
| IUPAC_name = 2-(2-hydroxyethoxy)ethyl 2-[ [3-(trifluoromethyl)phenyl]amino]benzoate |
| IUPAC_name = 2-(2-hydroxyethoxy)ethyl 2-[ [3-(trifluoromethyl)phenyl]amino]benzoate |
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| image = Etofenamate.png |
| image = Etofenamate.png |
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<!--Clinical data--> |
<!--Clinical data--> |
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| tradename = |
| tradename = |
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| Drugs.com = {{drugs.com|international|etofenamate}} |
| Drugs.com = {{drugs.com|international|etofenamate}} |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_US = <!-- A / B / C / D / X --> |
| pregnancy_US = <!-- A / B / C / D / X --> |
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| pregnancy_category = |
| pregnancy_category = |
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| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> |
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> |
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| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> |
| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C --> |
| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C --> |
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| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> |
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> |
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| legal_status = |
| legal_status = OTC |
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| routes_of_administration = |
| routes_of_administration = Topical (cream, gel, spray) |
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<!--Pharmacokinetic data--> |
<!--Pharmacokinetic data--> |
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| bioavailability = |
| bioavailability = |
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| protein_bound = |
| protein_bound = 98–99% |
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| metabolism = |
| metabolism = |
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| metabolites = [[Flufenamic acid]], [[hydroxyl]] derivatives |
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| elimination_half-life = |
| elimination_half-life = |
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| excretion = |
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| excretion = 35% [[renal]], mostly [[biliary]] |
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<!--Identifiers--> |
<!--Identifiers--> |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number = 30544-47-9 |
| CAS_number = 30544-47-9 |
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| ATC_prefix = M02 |
| ATC_prefix = M02 |
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| PubChem = 35375 |
| PubChem = 35375 |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank = |
| DrugBank = DB08984 |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 32560 |
| ChemSpiderID = 32560 |
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<!--Chemical data--> |
<!--Chemical data--> |
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| C=18 | H=18 | F=3 | N=1 | O=4 |
| C=18 | H=18 | F=3 | N=1 | O=4 |
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| molecular_weight = 369.33503 g/mol |
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| smiles = FC(F)(F)c1cc(ccc1)Nc2ccccc2C(=O)OCCOCCO |
| smiles = FC(F)(F)c1cc(ccc1)Nc2ccccc2C(=O)OCCOCCO |
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| InChI = 1/C18H18F3NO4/c19-18(20,21)13-4-3-5-14(12-13)22-16-7-2-1-6-15(16)17(24)26-11-10-25-9-8-23/h1-7,12,22-23H,8-11H2 |
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| InChIKey = XILVEPYQJIOVNB-UHFFFAOYAL |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI = 1S/C18H18F3NO4/c19-18(20,21)13-4-3-5-14(12-13)22-16-7-2-1-6-15(16)17(24)26-11-10-25-9-8-23/h1-7,12,22-23H,8-11H2 |
| StdInChI = 1S/C18H18F3NO4/c19-18(20,21)13-4-3-5-14(12-13)22-16-7-2-1-6-15(16)17(24)26-11-10-25-9-8-23/h1-7,12,22-23H,8-11H2 |
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'''Etofenamate''' is a [[nonsteroidal anti-inflammatory drug]] (NSAID) used for the treatment of joint and muscular [[pain]].<ref>{{cite journal | vauthors = Chlud K | title = [Use of topical non-steroidal anti-inflammatory drugs in aggravated and decompensated arthroses] | language = German | journal = Wiener Medizinische Wochenschrift | volume = 149 | issue = 19–20 | pages = 546–7 | year = 1999 | pmid = 10637963 }}</ref> It is available for topical application as a cream, a gel or as a spray. |
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'''Etofenamate''' is a drug used for joint and muscular [[pain]]. |
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Etofenamate is acutely toxic if swallowed; it is also very toxic to aquatic life, with long lasting effects.<ref>{{cite web | work = [[PubChem]] | url = https://pubchem.ncbi.nlm.nih.gov/compound/35375 | title = Etofenamate }}</ref>{{Unreliable medical source|date=February 2019}} |
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== References == |
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{{reflist}} |
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{{Anti-inflammatory and antirheumatic products}} |
{{Anti-inflammatory and antirheumatic products}} |
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{{NSAIDs}} |
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{{Topical products for joint and muscular pain}} |
{{Topical products for joint and muscular pain}} |
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{{Prostanoidergics}} |
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[[Category:Nonsteroidal anti-inflammatory drugs]] |
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[[Category: |
[[Category:Trifluoromethyl compounds]] |
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[[Category:Organofluorides]] |
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[[Category:Anthranilates]] |
[[Category:Anthranilates]] |
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[[Category:Ethers]] |
[[Category:Ethers]] |
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[[Category: |
[[Category:Primary alcohols]] |
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{{musculoskeletal-drug-stub}} |
{{musculoskeletal-drug-stub}} |
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[[de:Etofenamat]] |
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[[nl:Etofenamaat]] |
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[[pl:Etofenamat]] |
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