IGFBP5

IGFBP5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BOE, 1H59
Identifiers
Aliases	IGFBP5, IBP5, insulin like growth factor binding protein 5
External IDs	OMIM: 146734; MGI: 96440; HomoloGene: 56489; GeneCards: IGFBP5; OMA:IGFBP5 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q35 Start 216,672,105 bp End 216,695,549 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 C3|1 36.94 cM Start 72,897,091 bp End 72,914,043 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla urethra saphenous vein nipple vena cava cardia pylorus canal of the cervix left uterine tube right ovary Top expressed in ciliary body external carotid artery molar lactiferous gland saccule extraocular muscle ankle otic placode otic vesicle internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function fibronectin binding insulin-like growth factor binding growth factor binding insulin-like growth factor I binding insulin-like growth factor II binding protein binding Cellular component insulin-like growth factor ternary complex extracellular region insulin-like growth factor binding protein complex endoplasmic reticulum lumen extracellular space Biological process negative regulation of smooth muscle cell proliferation negative regulation of translation positive regulation of protein kinase B signaling intracellular signal transduction negative regulation of growth glucose homeostasis female pregnancy cellular response to organic cyclic compound negative regulation of smooth muscle cell migration negative regulation of osteoblast differentiation regulation of glucose metabolic process negative regulation of cell migration positive regulation of insulin-like growth factor receptor signaling pathway regulation of cell growth osteoblast differentiation response to growth hormone glucose metabolic process negative regulation of insulin-like growth factor receptor signaling pathway hair follicle morphogenesis regulation of growth negative regulation of muscle tissue development striated muscle cell differentiation lung alveolus development negative regulation of skeletal muscle hypertrophy type B pancreatic cell proliferation cellular response to cAMP signal transduction mammary gland involution ageing post-translational protein modification positive regulation of vascular associated smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell migration regulation of insulin-like growth factor receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3488 16011 Ensembl ENSG00000115461 ENSMUSG00000026185 UniProt P24593 Q07079 RefSeq (mRNA) NM_000599 NM_010518 RefSeq (protein) NP_000590 NP_034648 Location (UCSC) Chr 2: 216.67 – 216.7 Mb Chr 1: 72.9 – 72.91 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Insulin-like growth factor-binding protein 5 (IBF-5) is a protein that in humans is encoded by the IGFBP5 gene. An IGFBP5 gene was recently identified as being important for adaptation to varying water salinity in fish.

Further reading

• Mohan S, Farley JR, Baylink DJ (1996). "Age-related changes in IGFBP-4 and IGFBP-5 levels in human serum and bone: implications for bone loss with aging". Prog. Growth Factor Res. 6 (2–4): 465–73. doi:10.1016/0955-2235(95)00027-5. PMID 8817691.
• Schneider MR, Wolf E, Hoeflich A, Lahm H (2002). "IGF-binding protein-5: flexible player in the IGF system and effector on its own". J. Endocrinol. 172 (3): 423–40. doi:10.1677/joe.0.1720423. PMID 11874691.
• Firth SM, Baxter RC (2003). "Cellular actions of the insulin-like growth factor binding proteins". Endocr. Rev. 23 (6): 824–54. doi:10.1210/er.2001-0033. PMID 12466191.
• Shimasaki S, Shimonaka M, Zhang HP, Ling N (1991). "Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human". J. Biol. Chem. 266 (16): 10646–53. doi:10.1016/S0021-9258(18)99272-0. PMID 1709938.
• Ehrenborg E, Vilhelmsdotter S, Bajalica S, et al. (1991). "Structure and localization of the human insulin-like growth factor-binding protein 2 gene". Biochem. Biophys. Res. Commun. 176 (3): 1250–5. doi:10.1016/0006-291X(91)90420-C. PMID 1710112.
• Andress DL, Birnbaum RS (1991). "A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells". Biochem. Biophys. Res. Commun. 176 (1): 213–8. doi:10.1016/0006-291X(91)90911-P. PMID 1850257.
• Kiefer MC, Ioh RS, Bauer DM, Zapf J (1991). "Molecular cloning of a new human insulin-like growth factor binding protein". Biochem. Biophys. Res. Commun. 176 (1): 219–25. doi:10.1016/0006-291X(91)90912-Q. PMID 1850258.
• Ilvesmäki V, Blum WF, Voutilainen R (1994). "Insulin-like growth factor binding proteins in the human adrenal gland". Mol. Cell. Endocrinol. 97 (1–2): 71–9. doi:10.1016/0303-7207(93)90212-3. PMID 7511544. S2CID 22503525.
• Kou K, James PL, Clemmons DR, et al. (1994). "Identification of two clusters of mouse insulin-like growth factor binding protein genes on chromosomes 1 and 11". Genomics. 21 (3): 653–5. doi:10.1006/geno.1994.1329. PMID 7525452.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Nam TJ, Busby W, Clemmons DR (1997). "Insulin-like growth factor binding protein-5 binds to plasminogen activator inhibitor-I". Endocrinology. 138 (7): 2972–8. doi:10.1210/endo.138.7.5230. PMID 9202242.
• Twigg SM, Baxter RC (1998). "Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit". J. Biol. Chem. 273 (11): 6074–9. doi:10.1074/jbc.273.11.6074. PMID 9497324.
• Zheng B, Clarke JB, Busby WH, et al. (1998). "Insulin-like growth factor-binding protein-5 is cleaved by physiological concentrations of thrombin". Endocrinology. 139 (4): 1708–14. doi:10.1210/endo.139.4.5945. PMID 9528953.
• Twigg SM, Kiefer MC, Zapf J, Baxter RC (1998). "Insulin-like growth factor-binding protein 5 complexes with the acid-labile subunit. Role of the carboxyl-terminal domain". J. Biol. Chem. 273 (44): 28791–8. doi:10.1074/jbc.273.44.28791. PMID 9786878.
• Kalus W, Zweckstetter M, Renner C, et al. (1999). "Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions". EMBO J. 17 (22): 6558–72. doi:10.1093/emboj/17.22.6558. PMC 1171003. PMID 9822601.
• Ständker L, Wobst P, Mark S, Forssmann WG (1999). "Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5". FEBS Lett. 441 (2): 281–6. doi:10.1016/S0014-5793(98)01497-5. PMID 9883900. S2CID 23392744.
• Kecha O, Martens H, Franchimont N, et al. (1999). "Characterization of the insulin-like growth factor axis in the human thymus". J. Neuroendocrinol. 11 (6): 435–40. doi:10.1046/j.1365-2826.1999.00343.x. PMID 10336724. S2CID 36605514.