Tim Hunt
Sir Tim Hunt | |
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.jpg) Tim Hunt di UCSF pada Mei 2009 | |
| Kelahiran | Richard Timothy Hunt 19 Februari 1943 |
| Kerakyatan | United Kingdom |
| Pendidikan | |
| Pusat pendidikan | Universiti Cambridge (BA, PhD) |
| Terkenal kerana | Pengawalan kitaran sel |
| Pasangan | Mary Collins (k. 1995) |
| Anak-anak | 2 anak perempuan |
| Anugerah |
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| Kerjaya saintifik | |
| Bidang | Kitaran sel |
| Institusi | |
| Tesis | The synthesis of haemoglobin (1969) |
| Penasihat kedoktoran | Asher Korner |
| Pelajar kedoktoran | |
| Dipengaruhi oleh | Anne Ridley[7][8] |
| Laman web rasmi | crick |
Sir Richard Timothy Hunt, FRS FMedSci FRSE MAE (lahir 19 Februari 1943) ialah ahli biokimia dan fisiologi molekul British. Beliau dianugerahkan Hadiah Nobel 2001 dalam Fisiologi atau Perubatan bersama Paul Nurse dan Leland H. Hartwell untuk penemuan molekul protein mereka yang mengawal pembahagian sel. Khususnya, Hunt menemui siklin, protein dalam telur landak laut yang diagregat secara kitaran dan habis semasa kitaran pembahagian sel.
Penerbitan terpilih
[sunting | sunting sumber]- Mochida, Satoru; Maslen, Sarah L; Skehel, Mark; Hunt, Tim (2010). "Greatwall phosphorylates an inhibitor of protein phosphatase 2Α that is essential for mitosis". Science. 330 (6011): 1670–1673. doi:10.1126/science.1195689. PMID 21164013.
- Mochida, Satoru; Hunt, Tim (2007). "Calcineurin is required to release Xenopus egg extracts from meiotic M phase". Nature. 449: 336–340. doi:10.1038/nature06121. PMID 17882219.
- Rouse, John; Cohen, Philip; Trigon, Sylviane; Morange, Michel; Alonso-Llamazares, Ana; Zamanillo, Daniel; Hunt, Tim; Nebreda, Angel R. (1994). "A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins". Cell. 78 (6): 1027–1037. doi:10.1016/0092-8674(94)90277-1. ISSN 0092-8674. PMID 7923353.
- Evans, Tom; Rosenthal, Eric T.; Youngblom, Jim; Distel, Dan; Hunt, Tim (1983). "Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division". Cell. 33 (2): 389–396. doi:10.1016/0092-8674(83)90420-8. ISSN 0092-8674. PMID 6134587.
- Farrell, Paul J.; Balkow, Ken; Hunt, Tim; Jackson, Richard J.; Trachsel, Hans (1977). "Phosphorylation of initiation factor eIF-2 and the control of reticulocyte protein synthesis". Cell. 11 (1): 187–200. doi:10.1016/0092-8674(77)90330-0. ISSN 0092-8674. PMID 559547.
- Poon, R. Y.; Yamashita, K.; Adamczewski, J. P.; Hunt, T.; Shuttleworth, J. (1993). "The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2". EMBO Journal. 12: 3123–3132. PMC 413578. PMID 8393783.
- Nebreda, A.R.; Hunt, T. (1993). "The c-mos proto-oncogene protein kinase turns on and maintains the activity of MAP kinase, but not MPF, in cell-free extracts of Xenopus oocytes and eggs". EMBO J. 12: 1979–1986. PMC 413419. PMID 8387916.
- Craig, D.; Howell, M.T.; Gibbs, C.L.; Hunt, T.; Jackson, R.J. (1992). "Plasmid cDNA-directed protein synthesis in a couple eukaryotic in vitro transcription-translation system". Nucleic Acids Res. 20: 4987–4995. doi:10.1093/nar/20.19.4987. PMC 334274. PMID 1383935.
- Standart, N.; Dale, M.; Stewart, E.; Hunt, T. (1990). "Maternal mRNA from clam oocytes can be specifically unmasked in vitro by antisense RNA complementary to the 3' untranslated region". Genes Dev. 4: 2157–2168. doi:10.1101/gad.4.12a.2157. PMID 2148535.
- Gautier, J.; Minshull, J.; Lohka, M.; Glotzer, M.; Hunt, T.; Maller, J.L. (1990). "Cyclin is a component of MPF from Xenopus". Cell. 60: 487–494. doi:10.1016/0092-8674(90)90599-a. PMID 1967981.
- Standart, N.; Minshull, J.; Pines, J.; Hunt, T. (1987). "Cyclin synthesis, modification and destruction during meiotic maturation of the starfish oocyte". Dev. Biol. 124: 248–258. doi:10.1016/0012-1606(87)90476-3. PMID 15669148.
- Minshull, J.; Hunt, T. (1986). "The use of single-stranded DNA and RNase H to promote quantitative 'hybrid arrest of translation' of mRNA/DNA hybrids in reticulocyte lysate cell-free translations". Nucleic Acids Res. 14: 6433–6451. doi:10.1093/nar/14.16.6433. PMC 311656. PMID 3018671.
- Hunt, T.; Herbert, P.; Campbell, E.A.; Delidakis, C.; Jackson, R.J. (1983). "The use of affinity chromatography on 2'-5'ADP- Sepharose reveals a requirement for NADPH, thioredoxin and thioredoxin reductase for the maintenance of high protein synthesis activity in rabbit reticulocyte lysates". Eur. J. Biochem. 131: 303–311. doi:10.1111/j.1432-1033.1983.tb07263.x. PMID 6299735.
- Rosenthal, E.T.; Hunt, T.; Ruderman, J.V. (1980). "Selective translation of mRNA controls the pattern of protein synthesis during early development of the surf clam, Spisula solidissima". Cell. 20: 487–494. doi:10.1016/0092-8674(80)90635-2. PMID 7190072.
- Hunter, A.R.; Hunt, T.; Knowland, J.S.; Zimmern, D. (1976). "Messenger RNA for the coat protein of tobacco mosaic virus". Nature. 260: 759–764. doi:10.1038/260759a0. PMID 1264250.
- Darnbrough, C.H.; Legon, S.; Hunt, T.; Jackson, R.J. (1973). "Initiation of protein synthesis: evidence for messenger RNA- independent binding of methionyl transfer RNA to the 40S ribosomal subunit". J. Mol. Biol. 76: 379–403. doi:10.1016/0022-2836(73)90511-1. PMID 4732074.
- Kosower, N.S.; Vanderhoff, G.A.; Benerofe, B.; Hunt, T.; Kosower, E.M. (1971). "Inhibition of protein synthesis by glutathione disulfide in the presence of glutathione". Biochem. Biophys. Res. Commun. 45: 816–821. doi:10.1016/0006-291x(71)90490-6. PMID 5128185.
- Ehrenfeld, E.; Hunt, T. (1971). "Double-stranded poliovirus RNA inhibits initiation of protein synthesis by reticulocyte lysates". Proc. Natl. Acad. Sci. USA. 68: 1075–1078. doi:10.1073/pnas.68.5.1075. PMC 389116. PMID 4325000.
- Hunt, T.; Hunter, A.R.; Munro, A.J. (1968). "Control of haemoglobin synthesis: distribution of ribosomes on the messenger RNA for a and b chains". J. Mol. Biol. 36: 31–45. doi:10.1016/0022-2836(68)90217-9. PMID 5760537.
- Murray, Andrew; Hunt, Tim (1993). The Cell Cycle: An Introduction. Oxford: Oxford University Press. ISBN 978-0195095296.
- Wilson, John; Hunt, Tim (2014). Molecular Biology of the Cell: The Problems Book (ed. 6th). Taylor & Francis Ltd. ISBN 978-0815344537.
Rujukan
[sunting | sunting sumber]- ^ "Tim Hunt". Heidelberg: European Molecular Biology Organization.
- ^ Pelham, Hugh R. B. (1978). Transcription and Translation in Reticulocyte Lysates. lib.cam.ac.uk (Tesis). University of Cambridge. OCLC 500538683.
- ^ "Sir Hugh Pelham FMedSci FRS". London: Royal Society. Diarkibkan daripada yang asal pada 17 November 2015.
- ^ Pines, Jonathon Noe Joseph (1987). Cyclin : a major maternal message in sea urchin eggs. lib.cam.ac.uk (Tesis). University of Cambridge. OCLC 499166627.
- ^ Pines, Jonathon; Hunt, Tim (1987). "Molecular cloning and characterization of the mRNA for cyclin from sea urchin eggs". The EMBO Journal. 6 (10): 2987–2995. PMC 553735. PMID 2826125.
- ^ "Dr Jonathon Pines: Department of Zoology". Cambridge: cam.ac.uk. Diarkibkan daripada yang asal pada 2015-05-15.
- ^ Anon (2016). "Meet the Professors: Anne Ridley". kcl.ac.uk.
- ^ Anon (2006). "Anne Ridley Profile" (PDF). ascb.org. American Society for Cell Biology. Diarkibkan daripada yang asal (PDF) pada 2007-07-13.
Pautan luar
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