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. 1992 May;67(5):657–661. doi: 10.1136/adc.67.5.657

Biological role of lactoferrin.

L Sánchez 1, M Calvo 1, J H Brock 1
PMCID: PMC1793702  PMID: 1599309

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arnold R. R., Russell J. E., Champion W. J., Brewer M., Gauthier J. J. Bactericidal activity of human lactoferrin: differentiation from the stasis of iron deprivation. Infect Immun. 1982 Mar;35(3):792–799. doi: 10.1128/iai.35.3.792-799.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Aruoma O. I., Halliwell B. Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Are lactoferrin and transferrin promoters of hydroxyl-radical generation? Biochem J. 1987 Jan 1;241(1):273–278. doi: 10.1042/bj2410273. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BINGHAM E. W., ZITTLE C. A. RIBONUCLEASE OF BOVINE MILK: PURIFICATION AND PROPERTIES. Arch Biochem Biophys. 1964 Jul 20;106:235–239. doi: 10.1016/0003-9861(64)90182-1. [DOI] [PubMed] [Google Scholar]
  4. Breton-Gorius J., Mason D. Y., Buriot D., Vilde J. L., Griscelli C. Lactoferrin deficiency as a consequence of a lack of specific granules in neutrophils from a patient with recurrent infections. Detection by immunoperoxidase staining for lactoferrin and cytochemical electron microscopy. Am J Pathol. 1980 May;99(2):413–428. [PMC free article] [PubMed] [Google Scholar]
  5. Brines R. D., Brock J. H. The effect of trypsin and chymotrypsin on the in vitro antimicrobial and iron-binding properties of lactoferrin in human milk and bovine colostrum. Unusual resistance of human apolactoferrin to proteolytic digestion. Biochim Biophys Acta. 1983 Sep 13;759(3):229–235. doi: 10.1016/0304-4165(83)90317-3. [DOI] [PubMed] [Google Scholar]
  6. Britton J. R., Koldovský O. Gastric luminal digestion of lactoferrin and transferrin by preterm infants. Early Hum Dev. 1989 May;19(2):127–135. doi: 10.1016/0378-3782(89)90123-0. [DOI] [PubMed] [Google Scholar]
  7. Brock J. H. Lactoferrin in human milk: its role in iron absorption and protection against enteric infection in the newborn infant. Arch Dis Child. 1980 Jun;55(6):417–421. doi: 10.1136/adc.55.6.417. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Broxmeyer H. E., Smithyman A., Eger R. R., Meyers P. A., de Sousa M. Identification of lactoferrin as the granulocyte-derived inhibitor of colony-stimulating activity production. J Exp Med. 1978 Oct 1;148(4):1052–1067. doi: 10.1084/jem.148.4.1052. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Bullen J. J., Armstrong J. A. The role of lactoferrin in the bactericidal function of polymorphonuclear leucocytes. Immunology. 1979 Apr;36(4):781–791. [PMC free article] [PubMed] [Google Scholar]
  10. Bullen J. J., Rogers H. J., Leigh L. Iron-binding proteins in milk and resistance to Escherichia coli infection in infants. Br Med J. 1972 Jan 8;1(5792):69–75. doi: 10.1136/bmj.1.5792.69. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Butler T. W., Grossi C. E., Canessa A., Pistoia V., Barton J. C. Immunoreactive lactoferrin in resting, activated, and neoplastic lymphocytes. Leuk Res. 1990;14(5):441–447. doi: 10.1016/0145-2126(90)90030-d. [DOI] [PubMed] [Google Scholar]
  12. Davidson L. A., Lönnerdal B. Fe-saturation and proteolysis of human lactoferrin: effect on brush-border receptor-mediated uptake of Fe and Mn. Am J Physiol. 1989 Dec;257(6 Pt 1):G930–G934. doi: 10.1152/ajpgi.1989.257.6.G930. [DOI] [PubMed] [Google Scholar]
  13. Davidson L. A., Lönnerdal B. Specific binding of lactoferrin to brush-border membrane: ontogeny and effect of glycan chain. Am J Physiol. 1988 Apr;254(4 Pt 1):G580–G585. doi: 10.1152/ajpgi.1988.254.4.G580. [DOI] [PubMed] [Google Scholar]
  14. Derisbourg P., Wieruszeski J. M., Montreuil J., Spik G. Primary structure of glycans isolated from human leucocyte lactotransferrin. Absence of fucose residues questions the proposed mechanism of hyposideraemia. Biochem J. 1990 Aug 1;269(3):821–825. doi: 10.1042/bj2690821. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Duncan R. L., Jr, McArthur W. P. Lactoferrin-mediated modulation of mononuclear cell activities. I. Suppression of the murine in vitro primary antibody responses. Cell Immunol. 1981 Sep 15;63(2):308–320. doi: 10.1016/0008-8749(81)90010-1. [DOI] [PubMed] [Google Scholar]
  16. Ellison R. T., 3rd, LaForce F. M., Giehl T. J., Boose D. S., Dunn B. E. Lactoferrin and transferrin damage of the gram-negative outer membrane is modulated by Ca2+ and Mg2+. J Gen Microbiol. 1990 Jul;136(7):1437–1446. doi: 10.1099/00221287-136-7-1437. [DOI] [PubMed] [Google Scholar]
  17. Erhardt G., Senft B. Veränderungen in der bakteriostatischen Aktivität des Lactoferrins während der Laktation sowie nach experimenteller Infektion der Milchdrüse mit Staphylococcus aureus. Zentralbl Veterinarmed A. 1982 Aug;29(6):405–419. [PubMed] [Google Scholar]
  18. Fairweather-Tait S. J., Balmer S. E., Scott P. H., Minski M. J. Lactoferrin and iron absorption in newborn infants. Pediatr Res. 1987 Dec;22(6):651–654. doi: 10.1203/00006450-198712000-00007. [DOI] [PubMed] [Google Scholar]
  19. Fransson G. B., Keen C. L., Lönnerdal B. Supplementation of milk with iron bound to lactoferrin using weanling mice: L. Effects on hematology and tissue iron. J Pediatr Gastroenterol Nutr. 1983 Nov;2(4):693–700. doi: 10.1097/00005176-198311000-00021. [DOI] [PubMed] [Google Scholar]
  20. Furmanski P., Li Z. P., Fortuna M. B., Swamy C. V., Das M. R. Multiple molecular forms of human lactoferrin. Identification of a class of lactoferrins that possess ribonuclease activity and lack iron-binding capacity. J Exp Med. 1989 Aug 1;170(2):415–429. doi: 10.1084/jem.170.2.415. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Goldman A. S., Garza C., Schanler R. J., Goldblum R. M. Molecular forms of lactoferrin in stool and urine from infants fed human milk. Pediatr Res. 1990 Mar;27(3):252–255. doi: 10.1203/00006450-199003000-00009. [DOI] [PubMed] [Google Scholar]
  22. Gordeuk V. R., Prithviraj P., Dolinar T., Brittenham G. M. Interleukin 1 administration in mice produces hypoferremia despite neutropenia. J Clin Invest. 1988 Dec;82(6):1934–1938. doi: 10.1172/JCI113812. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Hennart P. F., Brasseur D. J., Delogne-Desnoeck J. B., Dramaix M. M., Robyn C. E. Lysozyme, lactoferrin, and secretory immunoglobulin A content in breast milk: influence of duration of lactation, nutrition status, prolactin status, and parity of mother. Am J Clin Nutr. 1991 Jan;53(1):32–39. doi: 10.1093/ajcn/53.1.32. [DOI] [PubMed] [Google Scholar]
  24. Houghton M. R., Gracey M., Burke V., Bottrell C., Spargo R. M. Breast milk lactoferrin levels in relation to maternal nutritional status. J Pediatr Gastroenterol Nutr. 1985 Apr;4(2):230–233. doi: 10.1097/00005176-198504000-00013. [DOI] [PubMed] [Google Scholar]
  25. Hu W. L., Mazurier J., Montreuil J., Spik G. Isolation and partial characterization of a lactotransferrin receptor from mouse intestinal brush border. Biochemistry. 1990 Jan 16;29(2):535–541. doi: 10.1021/bi00454a030. [DOI] [PubMed] [Google Scholar]
  26. Hutchens T. W., Henry J. F., Yip T. T., Hachey D. L., Schanler R. J., Motil K. J., Garza C. Origin of intact lactoferrin and its DNA-binding fragments found in the urine of human milk-fed preterm infants. Evaluation by stable isotopic enrichment. Pediatr Res. 1991 Mar;29(3):243–250. doi: 10.1203/00006450-199103000-00005. [DOI] [PubMed] [Google Scholar]
  27. Hutchens T. W., Henry J. F., Yip T. T. Structurally intact (78-kDa) forms of maternal lactoferrin purified from urine of preterm infants fed human milk: identification of a trypsin-like proteolytic cleavage event in vivo that does not result in fragment dissociation. Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):2994–2998. doi: 10.1073/pnas.88.8.2994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Lima M. F., Kierszenbaum F. Lactoferrin effects of phagocytic cell function. II. The presence of iron is required for the lactoferrin molecule to stimulate intracellular killing by macrophages but not to enhance the uptake of particles and microorganisms. J Immunol. 1987 Sep 1;139(5):1647–1651. [PubMed] [Google Scholar]
  29. Lu L., Hangoc G., Oliff A., Chen L. T., Shen R. N., Broxmeyer H. E. Protective influence of lactoferrin on mice infected with the polycythemia-inducing strain of Friend virus complex. Cancer Res. 1987 Aug 1;47(15):4184–4188. [PubMed] [Google Scholar]
  30. Masson P. L., Heremans J. F. Lactoferrin in milk from different species. Comp Biochem Physiol B. 1971 May 15;39(1):119–129. doi: 10.1016/0305-0491(71)90258-6. [DOI] [PubMed] [Google Scholar]
  31. Mazurier J., Legrand D., Hu W. L., Montreuil J., Spik G. Expression of human lactotransferrin receptors in phytohemagglutinin-stimulated human peripheral blood lymphocytes. Isolation of the receptors by antiligand-affinity chromatography. Eur J Biochem. 1989 Feb 1;179(2):481–487. doi: 10.1111/j.1432-1033.1989.tb14578.x. [DOI] [PubMed] [Google Scholar]
  32. Mazurier J., Montreuil J., Spik G. Visualization of lactotransferrin brush-border receptors by ligand-blotting. Biochim Biophys Acta. 1985 Dec 19;821(3):453–460. doi: 10.1016/0005-2736(85)90050-1. [DOI] [PubMed] [Google Scholar]
  33. McCormick J. A., Markey G. M., Morris T. C. Lactoferrin-inducible monocyte cytotoxicity for K562 cells and decay of natural killer lymphocyte cytotoxicity. Clin Exp Immunol. 1991 Jan;83(1):154–156. doi: 10.1111/j.1365-2249.1991.tb05606.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Moguilevsky N., Retegui L. A., Masson P. L. Comparison of human lactoferrins from milk and neutrophilic leucocytes. Relative molecular mass, isoelectric point, iron-binding properties and uptake by the liver. Biochem J. 1985 Jul 15;229(2):353–359. doi: 10.1042/bj2290353. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Moreau M. C., Duval-Iflah Y., Muller M. C., Raibaud P., Vial M., Gabilan J. C., Daniel N. Effet de la lactoferrine bovine et des IgG bovines données per os sur l'implantation de Escherichia coli dans le tube digestif de souris gnotoxéniques et de nouveau-nés humains. Ann Microbiol (Paris) 1983 Nov-Dec;134B(3):429–441. [PubMed] [Google Scholar]
  36. Nichols B. L., McKee K. S., Huebers H. A. Iron is not required in the lactoferrin stimulation of thymidine incorporation into the DNA of rat crypt enterocytes. Pediatr Res. 1990 May;27(5):525–528. doi: 10.1203/00006450-199005000-00022. [DOI] [PubMed] [Google Scholar]
  37. Nonnecke B. J., Smith K. L. Biochemical and antibacterial properties of bovine mammary secretion during mammary involution and at parturition. J Dairy Sci. 1984 Dec;67(12):2863–2872. doi: 10.3168/jds.S0022-0302(84)81648-3. [DOI] [PubMed] [Google Scholar]
  38. Powell M. J., Ogden J. E. Nucleotide sequence of human lactoferrin cDNA. Nucleic Acids Res. 1990 Jul 11;18(13):4013–4013. doi: 10.1093/nar/18.13.4013. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Prentice A., MacCarthy A., Stirling D. M., Vasquez-Velasquez L., Ceesay S. M. Breast-milk IgA and lactoferrin survival in the gastrointestinal tract--a study in rural Gambian children. Acta Paediatr Scand. 1989 Jul;78(4):505–512. doi: 10.1111/j.1651-2227.1989.tb17928.x. [DOI] [PubMed] [Google Scholar]
  40. Richie E. R., Hilliard J. K., Gilmore R., Gillespie D. J. Human milk-derived lactoferrin inhibits mitogen and alloantigen induced human lymphocyte proliferation. J Reprod Immunol. 1987 Oct;12(2):137–148. doi: 10.1016/0165-0378(87)90041-6. [DOI] [PubMed] [Google Scholar]
  41. Rochard E., Legrand D., Mazurier J., Montreuil J., Spik G. The N-terminal domain I of human lactotransferrin binds specifically to phytohemagglutinin-stimulated peripheral blood human lymphocyte receptors. FEBS Lett. 1989 Sep 11;255(1):201–204. doi: 10.1016/0014-5793(89)81091-9. [DOI] [PubMed] [Google Scholar]
  42. Ruz M., Solomons N. W. Mineral excretion during acute, dehydrating diarrhea treated with oral rehydration therapy. Pediatr Res. 1990 Feb;27(2):170–175. doi: 10.1203/00006450-199002000-00017. [DOI] [PubMed] [Google Scholar]
  43. Schulz-Lell G., Dörner K., Oldigs H. D., Sievers E., Schaub J. Iron availability from an infant formula supplemented with bovine lactoferrin. Acta Paediatr Scand. 1991 Feb;80(2):155–158. doi: 10.1111/j.1651-2227.1991.tb11826.x. [DOI] [PubMed] [Google Scholar]
  44. Scott P. H. Enzyme immunoassay of lactoferrin in newborn term infants: reference values and influence of diet. Ann Clin Biochem. 1989 Sep;26(Pt 5):407–411. doi: 10.1177/000456328902600505. [DOI] [PubMed] [Google Scholar]
  45. Scovern H., Kantor F. S. Local passive transfer of delayed-type hypersensitivity in the mouse. J Immunol. 1982 Jul;129(1):25–29. [PubMed] [Google Scholar]
  46. Slater K., Fletcher J. Lactoferrin derived from neutrophils inhibits the mixed lymphocyte reaction. Blood. 1987 May;69(5):1328–1333. [PubMed] [Google Scholar]
  47. Spik G., Brunet B., Mazurier-Dehaine C., Fontaine G., Montreuil J. Characterization and properties of the human and bovine lactotransferrins extracted from the faeces of newborn infants. Acta Paediatr Scand. 1982 Nov;71(6):979–985. doi: 10.1111/j.1651-2227.1982.tb09560.x. [DOI] [PubMed] [Google Scholar]
  48. Stowell K. M., Rado T. A., Funk W. D., Tweedie J. W. Expression of cloned human lactoferrin in baby-hamster kidney cells. Biochem J. 1991 Jun 1;276(Pt 2):349–355. doi: 10.1042/bj2760349. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Stryckmans P., Delforge A., Amson R. B., Prieels J. P., Telerman A., Bieva C., Deschuyteneer M., Rongé-Collard E. Lactoferrin: no evidence for its role in regulation of CSA production by human lymphocytes and monocytes. Blood Cells. 1984;10(2-3):369–395. [PubMed] [Google Scholar]
  50. Sun I. L., Crane F. L., Morré D. J., Löw H., Faulk W. P. Lactoferrin activates plasma membrane oxidase and Na+/H+ antiport activity. Biochem Biophys Res Commun. 1991 Apr 15;176(1):498–504. doi: 10.1016/0006-291x(91)90952-4. [DOI] [PubMed] [Google Scholar]
  51. Sánchez L., Aranda P., Pérez M. D., Calvo M. Concentration of lactoferrin and transferrin throughout lactation in cow's colostrum and milk. Biol Chem Hoppe Seyler. 1988 Sep;369(9):1005–1008. doi: 10.1515/bchm3.1988.369.2.1005. [DOI] [PubMed] [Google Scholar]
  52. Tuccari G., Barresi G., Arena F., Inferrera C. Immunocytochemical detection of lactoferrin in human gastric carcinomas and adenomas. Arch Pathol Lab Med. 1989 Aug;113(8):912–915. [PubMed] [Google Scholar]
  53. Van Snick J. L., Masson P. L., Heremans J. F. The involvement of lactoferrin in the hyposideremia of acute inflammation. J Exp Med. 1974 Oct 1;140(4):1068–1084. doi: 10.1084/jem.140.4.1068. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Weinberg E. D. Iron withholding: a defense against infection and neoplasia. Physiol Rev. 1984 Jan;64(1):65–102. doi: 10.1152/physrev.1984.64.1.65. [DOI] [PubMed] [Google Scholar]
  55. Winton E. F., Kinkade J. M., Jr, Vogler W. R., Parker M. B., Barnes K. C. In vitro studies of lactoferrin and murine granulopoiesis. Blood. 1981 Mar;57(3):574–578. [PubMed] [Google Scholar]
  56. Zagulski T., Lipiński P., Zagulska A., Broniek S., Jarzabek Z. Lactoferrin can protect mice against a lethal dose of Escherichia coli in experimental infection in vivo. Br J Exp Pathol. 1989 Dec;70(6):697–704. [PMC free article] [PubMed] [Google Scholar]

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