Caspase 1

Caspase 1, apoptosis-related cysteine peptidase
	Renderização PDB baseada em 1bmq.
Estruturas disponíveis
PDB	Busca de ortólogos: PDBe, RCSB
Lista de códigos PDB
	1BMQ, 1IBC, 1ICE, 1RWK, 1RWM, 1RWN, 1RWO, 1RWP, 1RWV, 1RWW, 1RWX, 1SC1, 1SC3, 1SC4, 2FQQ, 2H48, 2H4W, 2H4Y, 2H51, 2H54, 2HBQ, 2HBR, 2HBY, 2HBZ, 3D6F, 3D6H, 3D6M, 3E4C, 3NS7
Identificadores
Símbolos	CASP1; ICE; IL1BC; P45
IDs externos	OMIM: 147678 MGI: 96544 HomoloGene: 133272 ChEMBL: 4801 GeneCards: CASP1 Gene
Número EC	3.4.22.36
Ontologia do gene
Função molecular	•endopeptidase activity; •cysteine-type endopeptidase activity; •protein binding; •cysteine-type endopeptidase activator activity involved in apoptotic process;
Componente celular	•extracellular region; •cytoplasm; •cytosol; •IPAF inflammasome complex; •NLRP1 inflammasome complex; •NLRP3 inflammasome complex; •AIM2 inflammasome complex;
Processo biológico	•response to hypoxia; •proteolysis; •apoptotic process; •activation of cysteine-type endopeptidase activity involved in apoptotic process; •signal transduction; •response to lipopolysaccharide; •interleukin-1 beta production; •response to ATP; •nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway; •positive regulation of I-kappaB kinase/NF-kappaB signaling; •innate immune response; •positive regulation of interleukin-1 alpha secretion; •positive regulation of interleukin-1 beta secretion; •regulation of inflammatory response; •mitochondrial depolarization; •membrane hyperpolarization; •pyroptosis; •cellular response to mechanical stimulus; •cellular response to organic substance; •execution phase of apoptosis;
	Sources: Amigo / QuickGO
Ortólogos
	v; d; e;

A Caspase 1 é uma enzima que executa proteólise em proteínas, tais como em formas precursoras das citocinas inflamatórias, interleucina 1-β e interleucina 18, transformando-as em péptidos maduros.^[1] Pertence à família das proteases de cisteína, conhecidas como caspases, que quebram sempre as proteínas a seguir a um resíduos de aspartato. A caspase 1 é produzida como um zimogénio que é clivado em 2 subunidades (uma com 20 kDa (p20) e outra com 10 kDa (p10)) e depois transformada numa enzima activa. A caspase activa possui dois heterodímeros de p20 e p10.

Interage com uma proteína que contém um domínio CARD, denominada PYCARD (ou ASC) e está envolvida na activação de processos inflamatórios.^[2]

A Caspase 1 mostrou interação com NLRC4.^[3]^[4]

Referência

↑ Thornberry N, Bull H, Calaycay J, Chapman K, Howard A, Kostura M, Miller D, Molineaux S, Weidner J, Aunins J (1992). «A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes». Nature. 356 (6372): 768-74. PMID 1574116
↑ Mariathasan S, Newton K, Monack D, Vucic D, French D, Lee W, Roose-Girma M, Erickson S, Dixit V (2004). «Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf». Nature. 430 (6996): 213-8. PMID 15190255
↑ Damiano, Jason S; Oliveira Vasco, Welsh Kate, Reed John C (2004). «Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses». England. Biochem. J. 381 (Pt 1): 213–9. PMC 1133779. PMID 15107016. doi:10.1042/BJ20031506
↑ Damiano, J S; Stehlik C, Pio F, Godzik A, Reed J C (2001). «CLAN, a novel human CED-4-like gene». United States. Genomics. 75 (1-3): 77–83. ISSN 0888-7543. PMID 11472070. doi:10.1006/geno.2001.6579

[1] Thornberry N, Bull H, Calaycay J, Chapman K, Howard A, Kostura M, Miller D, Molineaux S, Weidner J, Aunins J (1992). «A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes». Nature. 356 (6372): 768-74. PMID 1574116

[2] Mariathasan S, Newton K, Monack D, Vucic D, French D, Lee W, Roose-Girma M, Erickson S, Dixit V (2004). «Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf». Nature. 430 (6996): 213-8. PMID 15190255

[pmid15107016-3] Damiano, Jason S; Oliveira Vasco, Welsh Kate, Reed John C (2004). «Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses». England. Biochem. J. 381 (Pt 1): 213–9. PMC 1133779. PMID 15107016. doi:10.1042/BJ20031506

[pmid11472070-4] Damiano, J S; Stehlik C, Pio F, Godzik A, Reed J C (2001). «CLAN, a novel human CED-4-like gene». United States. Genomics. 75 (1-3): 77–83. ISSN 0888-7543. PMID 11472070. doi:10.1006/geno.2001.6579

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v d e Proteases: Proteases de cisteína (EC 3.4.22)
Caspase	Caspase 1 - Caspase 2 - Caspase 3 - Caspase 4 - Caspase 5 - Caspase 8 - Caspase 9 - Caspase 12 - Caspase 13
Derivadas de frutos	Papaína - Ficaína - Bromelaína - Actinidaína
Calpaína	CAPN1 - CAPN2 - CAPN3 - CAPN5 - CAPN6 - CAPN7 - CAPN8 - CAPN9 - CAPN10 - CAPN11 - CAPN12 - CAPN13 - CAPN14 - CAPNS1 - CAPNS2
Catepsina	B · C · F · H · K · L1/L2 · S · W · Z
Outras	Clostripaína - Pró-coagulante do cancro - Separase - Calpaína - Autofagina