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183 results

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Page 1
SLAMF7 engagement superactivates macrophages in acute and chronic inflammation.
Simmons DP, Nguyen HN, Gomez-Rivas E, Jeong Y, Jonsson AH, Chen AF, Lange JK, Dyer GS, Blazar P, Earp BE, Coblyn JS, Massarotti EM, Sparks JA, Todd DJ; Accelerating Medicines Partnership (AMP) RA/SLE Network; Rao DA, Kim EY, Brenner MB. Simmons DP, et al. Sci Immunol. 2022 Feb 11;7(68):eabf2846. doi: 10.1126/sciimmunol.abf2846. Epub 2022 Feb 11. Sci Immunol. 2022. PMID: 35148199 Free PMC article.
Induction of TNF-alpha after SLAMF7 engagement amplified inflammation through an autocrine signaling loop. We observed SLAMF7-induced gene programs not only in macrophages from rheumatoid arthritis patients but also in gut macrophages from patients with active Crohn's dise …
Induction of TNF-alpha after SLAMF7 engagement amplified inflammation through an autocrine signaling loop. We observed SLAMF7-induced …
PI3Kγ is a molecular switch that controls immune suppression.
Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA. Kaneda MM, et al. Nature. 2016 Nov 17;539(7629):437-442. doi: 10.1038/nature19834. Epub 2016 Sep 19. Nature. 2016. PMID: 27642729 Free PMC article.
Macrophages play critical, but opposite, roles in acute and chronic inflammation and cancer. In response to pathogens or injury, inflammatory macrophages express cytokines that stimulate cytotoxic T cells, whereas macrophages in neoplastic and parasiti …
Macrophages play critical, but opposite, roles in acute and chronic inflammation and cancer. In response to path …
Neuroinflammation.
Mukhara D, Oh U, Neigh GN. Mukhara D, et al. Handb Clin Neurol. 2020;175:235-259. doi: 10.1016/B978-0-444-64123-6.00017-5. Handb Clin Neurol. 2020. PMID: 33008528 Review.
We begin by detailing the pathology of neuroinflammation, distinguishing between acute and chronic inflammation, and examining contributions from the innate and adaptive immune systems. ...Finally, we highlight the possible role of exercise in alleviat …
We begin by detailing the pathology of neuroinflammation, distinguishing between acute and chronic inflammation, …
Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation.
Lima Giacobbo B, Doorduin J, Klein HC, Dierckx RAJO, Bromberg E, de Vries EFJ. Lima Giacobbo B, et al. Mol Neurobiol. 2019 May;56(5):3295-3312. doi: 10.1007/s12035-018-1283-6. Epub 2018 Aug 17. Mol Neurobiol. 2019. PMID: 30117106 Free PMC article. Review.
Activation of glia cells can induce an increase in the levels of pro- and antiinflammatory cytokines and reactive oxygen species, which can lead to the modulation of neuronal function and neurotoxicity observed in several brain pathologies. Understanding how neuroinflammat …
Activation of glia cells can induce an increase in the levels of pro- and antiinflammatory cytokines and reactive oxygen species, which can …
Predictable Irreversible Switching Between Acute and Chronic Inflammation.
Abudukelimu A, Barberis M, Redegeld FA, Sahin N, Westerhoff HV. Abudukelimu A, et al. Front Immunol. 2018 Aug 7;9:1596. doi: 10.3389/fimmu.2018.01596. eCollection 2018. Front Immunol. 2018. PMID: 30131800 Free PMC article.
Upon binding of antigen-antibody complexes to immunoglobulin-like receptors, mast cells release tumor necrosis factor-alpha and proteases, causing fibroblasts to release endogenous antigens that may be cross reactive with exogenous antigens. We made a predictive dynamic ma …
Upon binding of antigen-antibody complexes to immunoglobulin-like receptors, mast cells release tumor necrosis factor-alpha and proteases, c …
GlycA, a novel biomarker of systemic inflammation and cardiovascular disease risk.
Connelly MA, Otvos JD, Shalaurova I, Playford MP, Mehta NN. Connelly MA, et al. J Transl Med. 2017 Oct 27;15(1):219. doi: 10.1186/s12967-017-1321-6. J Transl Med. 2017. PMID: 29078787 Free PMC article. Review.
Recent studies of GlycA from cross-sectional, observational and interventional studies have been highly informative, demonstrating that GlycA is elevated in acute and chronic inflammation, predicts death in healthy individuals and is asso …
Recent studies of GlycA from cross-sectional, observational and interventional studies have been highly informative, demonstrating th …
Significance of Extracellular Vesicles: Pathobiological Roles in Disease.
Yamamoto S, Azuma E, Muramatsu M, Hamashima T, Ishii Y, Sasahara M. Yamamoto S, et al. Cell Struct Funct. 2016 Nov 25;41(2):137-143. doi: 10.1247/csf.16014. Epub 2016 Sep 29. Cell Struct Funct. 2016. PMID: 27679938 Free article. Review.
EVs theoretically consist of microparticles/microvesicles, exosomes, and apoptotic bodies by different productive mechanisms. Clinically, EVs are observed in the blood stream of patients suffering from acute and chronic inflammation evoked by va …
EVs theoretically consist of microparticles/microvesicles, exosomes, and apoptotic bodies by different productive mechanisms. Clinically, EV …
The Unmysterious Roles of HSP90: Ovarian Pathology and Autoantibodies.
Pires ES. Pires ES. Adv Anat Embryol Cell Biol. 2017;222:29-44. doi: 10.1007/978-3-319-51409-3_2. Adv Anat Embryol Cell Biol. 2017. PMID: 28389749 Review.
They are immunodominant antigens for many common microbes, and thus their epitopes are recognized by the immune system. As HSPs are overexpressed at sites of acute and chronic inflammation, individuals are likely to be sensitized during the course of a …
They are immunodominant antigens for many common microbes, and thus their epitopes are recognized by the immune system. As HSPs are overexpr …
Neutrophil activation and neutrophil extracellular traps (NETs) in COVID-19 ARDS and immunothrombosis.
Cesta MC, Zippoli M, Marsiglia C, Gavioli EM, Cremonesi G, Khan A, Mantelli F, Allegretti M, Balk R. Cesta MC, et al. Eur J Immunol. 2023 Jan;53(1):e2250010. doi: 10.1002/eji.202250010. Epub 2022 Nov 1. Eur J Immunol. 2023. PMID: 36239164 Free PMC article. Review.
Neutrophils play a vital role in the immunopathology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by triggering the formation of neutrophil extracellular traps (NETs), producing cytokines including interleukin-8 (CXCL8), and mediating the recruitment …
Neutrophils play a vital role in the immunopathology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by triggering …
Investigating immunoregulatory effects of myeloid cell autophagy in acute and chronic inflammation.
Hasnat MA, Cheang I, Dankers W, Lee JP, Truong LM, Pervin M, Jones SA, Morand EF, Ooi JD, Harris J. Hasnat MA, et al. Immunol Cell Biol. 2022 Sep;100(8):605-623. doi: 10.1111/imcb.12562. Epub 2022 Jun 21. Immunol Cell Biol. 2022. PMID: 35652357 Free PMC article.
Here, we assessed the impact of genetic depletion of the autophagy gene Atg7 in myeloid cells on acute and chronic inflammation. In a model of acute lipopolysaccharide-induced endotoxemia, loss of autophagy in myeloid cells resulted in increased releas …
Here, we assessed the impact of genetic depletion of the autophagy gene Atg7 in myeloid cells on acute and chronic i …
183 results