… Here we present the first structure of an intact and fully active type IA DNA topoisomerase,
E. coli DNA topoisomerase III. By comparing this structure with that of the 67 kDa N-terminal …

… that relative to yeast DNA topoisomerases I and II, yeast DNA topoisomerase III has a much
… activity of DNA topoisomerase III but possessing two robust DNA topoisomerases I and II …

… , topoisomerase III supports fork movement on a circular DNA … by the ability of topoisomerase
III, but not topoisomerase I, to“… that are present in the replicating DNA(38,39,40). Thus, …

… subfamily whose members also include bacterial DNA topoisomerases I and III, yeast
DNA topoisomerase III, and the enzyme “reverse gyrase” found in hyperthermophiles (4). …

… between Sgs1 and DNA topoisomerase III in vitro and in vivo… for interaction with DNA
topoisomerase III. Gel electrophoretic … binding of DNA topoisomerase III to single-stranded DNA. A …

… to u protein and is insensitive to inhibitors of DNA gyrase. The E. coli topoisomerase we
report in this paper seems to be identical with topo III in its molecular size and enzymatic …

… and DNA topoisomerase … DNA topoisomerases, Tyrosyl-DNA phosphodiesterase,
checkpoint inhibitors, and HIV-1 integrase inhibitors. Two of his patented novel topoisomerase …

… of the RecQ family of DNA helicases are known to interact with DNA topoisomerase III (Top3). …
RecQ family members has been shown to interact with DNA topoisomerase III (Top3) 1 ( …

… DNA was prepared by incubating circular bubble DNA (50 ng/μl) with yeast DNA topoisomerase
I (5 ng/μl) and ethidium bromide (EtBr; 1.5 μg/ml) in DNA topoisomerase I relaxation …

… In the case of topoisomerase III, we observed great correlated movements of domain II
along eigenvector 1 that likely function in the long-range protein communications necessary to …