Cyclin A in cell cycle control and cancer

CH Yam, TK Fung, RYC Poon - Cellular and Molecular Life Sciences …, 2002 - Springer
Cyclin A is particularly interesting among the cyclin family because it can activate two
different cyclin… An embryonic form of cyclin A that is only essential for spermatogenesis is also …

The crystal structure of cyclin A

NR Brown, MEM Noble, JA Endicott, EF Garman… - Structure, 1995 - cell.com
… acids, termed the cyclin box. From the determination of the structure of cyclin A, together with
… identify which parts of the cyclin molecule may contribute to cyclin A structure and function. …

Cyclin A is required at two points in the human cell cycle.

M Pagano, R Pepperkok, F Verde, W Ansorge… - The EMBO …, 1992 - embopress.org
… -cyclin A antibodies at distinct times. Cyclin A binds both cdk2 and cdc2, giving two distinct
cyclin … These results suggest that cyclin A defines novel control points of the human cell cycle. …

Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B

J Pines, T Hunter - Nature, 1990 - nature.com
… of cyclin A through the cell cycle compared with cyclin B. By immunoblotting we found the
amount of both cyclin A … to detect cyclin A-associated p34“ by immunoblotting the anti-cyclin A …

Cyclin A and cyclin D1 as significant prognostic markers in colorectal cancer patients

AA Bahnassy, ARN Zekri, S El-Houssini… - BMC …, 2004 - Springer
… The staining index of cyclin D1 was significantly … of cyclin A and D1 and amplification of
cyclin D1 were associated with reduced overall survival. Multivariate analysis shows that cyclin

Cyclin A is required for the onset of DNA replication in mammalian fibroblasts

F Girard, U Strausfeld, A Fernandez, NJC Lamb - Cell, 1991 - cell.com
… spot corresponding to p82 cyclin 8, even when 5-10 pg of purified human cyclin B protein was
… of the anti-cyclin A antibodies and their lack of cross-reactivity with cyclin B as also shown …

The prognostic value and overexpression of cyclin A is correlated with gene amplification of both cyclin A and cyclin E in breast cancer patient

A Husdal, G Bukholm… - Analytical Cellular …, 2006 - Wiley Online Library
… review article given evidence for that cyclin E can modulate the expression of cyclin A [4]. In
cyclin E was correlated to overexpression of cyclin A, but not to protein expression of cyclin E…

Human cyclin A is required for mitosis until mid prophase

N Furuno, N Den Elzen, J Pines - The Journal of cell biology, 1999 - rupress.org
cyclin partner has altered to cyclin A. We have also used the amino terminus of p21 as a
specific inhibitor of cyclin A/CDK2 to demonstrate that cyclin … If cyclin A/CDK2 is inhibited in early …

A link between cyclin A expression and adhesion-dependent cell cycle progression

TM Guadagno, M Ohtsubo, JM Roberts, RK Assoian - Science, 1993 - science.org
… In contrast, the expression of Cdc2, Cdk2, cyclin D1, and cyclin E was … a cyclin A
complementary DNA resulted in adhesion-independent accumulation of cyclin A protein and cyclin A-…

Cyclin E and Cyclin A as Canadidates for the Restriction Point Protein

QP Dou, AH Levin, S Zhao, AB Pardee - Cancer research, 1993 - AACR
… We report here that cyclin E and cyclin A proteins as well as their dependent histone H1
kinases … We suggest that the molecular basis of the R protein could be cyclin production and …