Ekdizon 20-monooksigenaza
| Ekdizon 20-monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.99.22 | ||||||||
| CAS broj | 55071-97-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Ekdizon 20-monooksigenaza (EC 1.14.99.22, alfa-ekdizonska C-20 hidroksilaza, ekdizonska 20-hidroksilaza) je enzim sa sistematskim imenom ekdizon,vodonik-donor:kiseonik oksidoreduktaza (20-hidroksilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ekdizon + AH2 + O2 20-hidroksiekdizon + A + H2O
Enzim iz telesne masti insekata je hem-tiolatni protein (P-450). NADPH može da deluje kao donor vodonika.
- ↑ Johnson, P. and Rees, H.H. (1977). „The mechanism of C-20 hydroxylation of α-ecdysone in the desert locust, Schistocerca gregaria”. Biochem. J. 168: 513-520. PMID 606249.
- ↑ Nigg, H.N., Svoboda, J.A., Thompson, M.J., Dutky, S.R., Kaplanis, J.N. and Robbins, W.E. (1976). „Ecdysome 20-hydroxylase from the midgut of the tobacco hornworm (Manduca sexta L.)”. Experientia 32: 438-439. PMID 5286.
- ↑ Smith, S.L., Bollenbacher, W.E., Cooper, D.Y., Schleyer, H., Wielgus, J.J. and Gilbert, L.I. (1979). „Ecdysone 20-monooxygenase: characterization of an insect cytochrome p-450 dependent steroid hydroxylase”. Mol. Cell. Endocrinol. 15: 111-133. PMID 488526.
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- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
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