Fosfodiestaraza I
| Fosfodiestaraza I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.4.1 | ||||||||
| CAS broj | 9025-82-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Fosfodiestaraza I (EC 3.1.4.1, 5'-eksonukleaza, 5'-fosfodiesteraza, 5'-nukleotidna fosfodiesteraza, oligonukleatna 5'-nukleotidohidrolaza, 5' nukleotid fosfodiesteraza/alkalinska fosfodiesteraza I, 5'-NPDaza, 5'-PDaza, 5'-PDE, 5'NPDE, alkalinska fosfodiesteraza, nukleotid pirofosfataza/fosfodiesteraza I, ortofosforna diestarska fosfohidrolaza, PDE I, fosfodiesteraza, eksonukleaza I) je enzim sa sistematskim imenom oligonukleotid 5'-nukleotidohidrolaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
- hidrolitički sukcesivno uklanja 5'-nukleotide sa 3'-hidroksi kraja oligonukleotida
Ovaj enzim hidrolizuje ribonukleotide i dezoksiribonukleotide.
- ↑ Khorana, G.H. (1961). „Phosphodiesterases”. u: Boyer, P.D., Lardy, H. and Myrbäck, K.. The Enzymes. 5 (2nd izd.). New York: Academic Press. str. 79-94.
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Khorana, G.H. (1961). „Phosphodiesterases”. u: Boyer, P.D., Lardy, H. and Myrbäck, K.. The Enzymes. 5 (2nd izd.). New York: Academic Press. str. 79-94.