5-HT_1F receptor

5-hidroksitriptaminski (serotoninski) receptor 1F
5-hidroksitriptaminski (serotoninski) receptor 1F
Identifikatori
Simboli	HTR1F; 5-HT1F; HTR1EL; MR77
Vanjski ID	OMIM: 182134 MGI: 99842 HomoloGene: 37361 IUPHAR: 5-HT1F GeneCards: HTR1F Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora; • receptorska aktivnost; • aktivnost serotoninskog receptora;
Celularna komponenta	• integralno sa ćelijskom membranom; • membrana;
Biološki proces	• prenos signala; • G-proteinska signalizacija, spregnuta sa cikličnim nukleotidnim sekundarnim glasnikom; • sinaptička transmisija;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	3355
Ensembl	ENSG00000179097
UniProt	P30939
RefSeq (mRNA)	NM_000866
RefSeq (protein)	NP_000857
Lokacija (UCSC)	Chr 3:; 88.12 - 88.12 Mb
PubMed pretraga	[1]

5-HT1F receptor (5-hidroksitriptaminski (serotoninski) receptor 1F, HTR1F je 5-HT₁ receptor. On je kodiran istoimenim humanim genom.^[1]^[2]^[3]^[4]^[5]

Ligandi

Agonisti

5-n-Butirilokis-DMT^[6]: >60-puta je selektivniji u odnosu na 5-HT_1E receptor
BRL-54443 - mešoviti 5-HT_1E/1F agonist
Eletriptan - mešoviti 5-HT_{1B/1D/1E/1F/2B/7} agonist
LY-334,370^[7] - kao i srodni benzamidi^[8]
LY-344,864 (N-[(3R)-3-(Dimetilamino)-2,3,4,9-tetrahidro-1H-karbazol-6-il]-4-fluorobenzamid)
Naratriptan - mešoviti 5-HT_1B/1D/1F agonist

Antagonisti

Selektivni antagonisti 5HT_1F receptora nisu dostupni.

Vidi još

Reference

^ „Entrez Gene: HTR1F 5-hydroxytryptamine (serotonin) receptor 1F”.
^ Adham N, Kao HT, Schecter LE, Bard J, Olsen M, Urquhart D, Durkin M, Hartig PR, Weinshank RL, Branchek TA (1993). „Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase”. Proc. Natl. Acad. Sci. U.S.A. 90 (2): 408—12. Bibcode:1993PNAS...90..408A. PMC 45671 . PMID 8380639. doi:10.1073/pnas.90.2.408 .
^ Lovenberg TW, Erlander MG, Baron BM, Racke M, Slone AL, Siegel BW, Craft CM, Burns JE, Danielson PE, Sutcliffe JG (1993). „Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes”. Proc. Natl. Acad. Sci. U.S.A. 90 (6): 2184—8. Bibcode:1993PNAS...90.2184L. PMC 46050 . PMID 8384716. doi:10.1073/pnas.90.6.2184 .
^ Erdmann J, Shimron-Abarbanell D, Shridhar V, Smith DI, Propping P, Nöthen MM (1997). „Assignment of the human serotonin 1F receptor gene (HTR1F) to the short arm of chromosome 3 (3p13-p14.1)”. Mol. Membr. Biol. 14 (3): 133—5. PMID 9394293. doi:10.3109/09687689709048173.
^ Maassen VanDenBrink A, Vergouwe MN, Ophoff RA, Naylor SL, Dauwerse HG, Saxena PR, Ferrari MD, Frants RR (1998). „Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients”. Am. J. Med. Genet. 77 (5): 415—20. PMID 9632173. doi:10.1002/(SICI)1096-8628(19980605)77:5<415::AID-AJMG12>3.0.CO;2-L.
^ Klein, M. T.; Dukat, M.; Glennon, R. A.; Teitler, M. (2011). „Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: A comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships”. The Journal of Pharmacology and Experimental Therapeutics. 337 (3): 860—867. PMC 3101003 . PMID 21422162. doi:10.1124/jpet.111.179606.
^ Wainscott DB, Krushinski JH, Audia JE, Schaus JM, Zgombick JM, Lucaites VL, Nelson DL (2005). „[³H]-LY-334,370, a novel radioligand for the 5-HT_1F receptor. I. In vitro characterization of binding properties”. Naunyn Schmiedebergs Arch. Pharmacol. 371 (3): 169—77. PMID 15900510. S2CID 2230855. doi:10.1007/s00210-005-1035-9.
^ Zhang D, Kohlman D, Krushinski J, Liang S, Ying BP, Reilly JE, Dinn SR, Wainscott DB, Nutter S, Gough W, Nelson DL, Schaus JM, Xu YC (2004). „Design, synthesis and evaluation of bicyclic benzamides as novel 5-HT_1F receptor agonists”. Bioorg. Med. Chem. Lett. 14 (24): 6011—6. PMID 15546719. doi:10.1016/j.bmcl.2004.09.079.

Dodatna literatura

Hoyer D, Hannon JP, Martin GR (2002). „Molecular, pharmacological and functional diversity of 5-HT receptors.”. Pharmacol. Biochem. Behav. 71 (4): 533—54. PMID 11888546. S2CID 25543069. doi:10.1016/S0091-3057(01)00746-8.
Raymond, JR; Mukhin, YV; Gelasco A; et al. (2002). „Multiplicity of mechanisms of serotonin receptor signal transduction.”. Pharmacol. Ther. 92 (2–3): 179—212. PMID 11916537. doi:10.1016/S0163-7258(01)00169-3.
Amlaiky N; Ramboz S; Boschert U; et al. (1992). „Isolation of a mouse "5HT1E-like" serotonin receptor expressed predominantly in hippocampus.”. J. Biol. Chem. 267 (28): 19761—4. PMID 1328180. doi:10.1016/S0021-9258(19)88617-9 .
Adham N; Kao, HT; Schecter, LE; et al. (1993). „Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase.”. Proc. Natl. Acad. Sci. U.S.A. 90 (2): 408—12. Bibcode:1993PNAS...90..408A. PMC 45671 . PMID 8380639. doi:10.1073/pnas.90.2.408 .
Lovenberg, TW; Erlander, MG; Baron, BM; et al. (1993). „Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes.”. Proc. Natl. Acad. Sci. U.S.A. 90 (6): 2184—8. Bibcode:1993PNAS...90.2184L. PMC 46050 . PMID 8384716. doi:10.1073/pnas.90.6.2184 .
Maassen VanDenBrink A; Vergouwe, MN; Ophoff, RA; et al. (1999). „Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients.”. Am. J. Med. Genet. 77 (5): 415—20. PMID 9632173. doi:10.1002/(SICI)1096-8628(19980605)77:5<415::AID-AJMG12>3.0.CO;2-L.
Strausberg, RL; Feingold, EA; Grouse, LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 .
Bhatnagar A; Sheffler, DJ; Kroeze, WK; et al. (2004). „Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors.”. J. Biol. Chem. 279 (33): 34614—23. PMID 15190056. doi:10.1074/jbc.M404673200 .
Gerhard, DS; Wagner L; Feingold, EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Hannula-Jouppi K; Kaminen-Ahola N; Taipale M; et al. (2006). „The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia.”. PLOS Genet. 1 (4): e50. PMC 1270007 . PMID 16254601. doi:10.1371/journal.pgen.0010050 .

Spoljašnje veze

„5-HT_1F”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.

[entrez-1] „Entrez Gene: HTR1F 5-hydroxytryptamine (serotonin) receptor 1F”.

[pmid8380639-2] Adham N, Kao HT, Schecter LE, Bard J, Olsen M, Urquhart D, Durkin M, Hartig PR, Weinshank RL, Branchek TA (1993). „Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase”. Proc. Natl. Acad. Sci. U.S.A. 90 (2): 408—12. Bibcode:1993PNAS...90..408A. PMC 45671 . PMID 8380639. doi:10.1073/pnas.90.2.408 .

[pmid8384716-3] Lovenberg TW, Erlander MG, Baron BM, Racke M, Slone AL, Siegel BW, Craft CM, Burns JE, Danielson PE, Sutcliffe JG (1993). „Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes”. Proc. Natl. Acad. Sci. U.S.A. 90 (6): 2184—8. Bibcode:1993PNAS...90.2184L. PMC 46050 . PMID 8384716. doi:10.1073/pnas.90.6.2184 .

[pmid9394293-4] Erdmann J, Shimron-Abarbanell D, Shridhar V, Smith DI, Propping P, Nöthen MM (1997). „Assignment of the human serotonin 1F receptor gene (HTR1F) to the short arm of chromosome 3 (3p13-p14.1)”. Mol. Membr. Biol. 14 (3): 133—5. PMID 9394293. doi:10.3109/09687689709048173.

[pmid9632173-5] Maassen VanDenBrink A, Vergouwe MN, Ophoff RA, Naylor SL, Dauwerse HG, Saxena PR, Ferrari MD, Frants RR (1998). „Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients”. Am. J. Med. Genet. 77 (5): 415—20. PMID 9632173. doi:10.1002/(SICI)1096-8628(19980605)77:5<415::AID-AJMG12>3.0.CO;2-L.

[6] Klein, M. T.; Dukat, M.; Glennon, R. A.; Teitler, M. (2011). „Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: A comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships”. The Journal of Pharmacology and Experimental Therapeutics. 337 (3): 860—867. PMC 3101003 . PMID 21422162. doi:10.1124/jpet.111.179606.

[pmid15900510-7] Wainscott DB, Krushinski JH, Audia JE, Schaus JM, Zgombick JM, Lucaites VL, Nelson DL (2005). „[³H]-LY-334,370, a novel radioligand for the 5-HT_1F receptor. I. In vitro characterization of binding properties”. Naunyn Schmiedebergs Arch. Pharmacol. 371 (3): 169—77. PMID 15900510. S2CID 2230855. doi:10.1007/s00210-005-1035-9.

[pmid15546719-8] Zhang D, Kohlman D, Krushinski J, Liang S, Ying BP, Reilly JE, Dinn SR, Wainscott DB, Nutter S, Gough W, Nelson DL, Schaus JM, Xu YC (2004). „Design, synthesis and evaluation of bicyclic benzamides as novel 5-HT_1F receptor agonists”. Bioorg. Med. Chem. Lett. 14 (24): 6011—6. PMID 15546719. doi:10.1016/j.bmcl.2004.09.079.

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