3-hydroxy-3-methylglutaryl-CoA reductase (Q415607)

http://www.ebi.ac.uk/interpro/protein/P04035

Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily

1 reference

http://www.ebi.ac.uk/interpro/protein/P04035

Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily

1 reference

http://www.ebi.ac.uk/interpro/protein/P04035

Hydroxymethylglutaryl-CoA reductase, N-terminal

1 reference

http://www.ebi.ac.uk/interpro/protein/P04035

Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily

1 reference

http://www.ebi.ac.uk/interpro/protein/P04035

Eukaryotic Sterol Transporter

1 reference

Transporter Classification Database ID

2.A.6.6.5

hierarchical database ID heuristic

2 October 2019

based on heuristic

Sterol-sensing domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

1 reference

8 April 2019

protein homodimerization activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

hydroxymethylglutaryl-CoA reductase (NADPH) activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

protein binding

IPI

1 reference

8 April 2019

The UBIAD1 prenyltransferase links menaquinone-4 [corrected] synthesis to cholesterol metabolic enzymes

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

IPI

NADP binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

1 reference

8 April 2019

NADPH binding

1 reference

8 April 2019

Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

oxidoreductase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

1 reference

8 April 2019

protein phosphatase 2A binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

endoplasmic reticulum membrane

cell component

Human 3-hydroxy-3-methylglutaryl coenzyme A reductase. Conserved domains responsible for catalytic activity and sterol-regulated degradation

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04035&geneProductId=UniProtKB:P04035

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04035&geneProductId=UniProtKB:P04035

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04035&geneProductId=UniProtKB:P04035

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04035&geneProductId=UniProtKB:P04035

24 April 2018

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

1 reference

8 April 2019

intracellular membrane-bounded organelle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

peroxisomal membrane

1 reference

24 April 2018

Localization of the pre-squalene segment of the isoprenoid biosynthetic pathway in mammalian peroxisomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04035&geneProductId=UniProtKB:P04035

peroxisomal membrane

endoplasmic reticulum membrane

Human 3-hydroxy-3-methylglutaryl coenzyme A reductase. Conserved domains responsible for catalytic activity and sterol-regulated degradation

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

biological process

visual learning

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

steroid metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

1 reference

8 April 2019

sterol biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04035&geneProductId=UniProtKB:P04035

1 reference

24 April 2018

negative regulation of striated muscle cell apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

coenzyme A metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

1 reference

8 April 2019

response to nutrient

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

positive regulation of skeletal muscle tissue development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

1 reference

8 April 2019

positive regulation of cardiac muscle cell apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

negative regulation of insulin secretion involved in cellular response to glucose stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

human ageing

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

negative regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

cholesterol metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

1 reference

8 April 2019

protein tetramerization

1 reference

8 April 2019

Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

isoprenoid biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

negative regulation of MAP kinase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

positive regulation of cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

positive regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

negative regulation of wound healing

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

ubiquinone metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

myoblast differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

response to ethanol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

positive regulation of stress-activated MAPK cascade

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

positive regulation of smooth muscle cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

steroid biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

1 reference

8 April 2019

regulation of lipid metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

1 reference

8 April 2019

regulation of cholesterol biosynthetic process

TAS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

1 reference

8 April 2019

cholesterol biosynthetic process

TAS

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04035&geneProductId=UniProtKB:P04035

3 references

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04035&geneProductId=UniProtKB:P04035

1 January 2018

Artemisinic acid inhibits melanogenesis through downregulation of C/EBP α-dependent expression of HMG-CoA reductase gene

GOA

curator

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04035&geneProductId=UniProtKB:P04035

cholesterol biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

8 April 2019

Artemisinic acid inhibits melanogenesis through downregulation of C/EBP α-dependent expression of HMG-CoA reductase gene

GOA

curator

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04035

physically interacts with

1 reference

2949

17 August 2016

1 reference

2950

17 August 2016

1 reference

2951

17 August 2016

1 reference

2739

17 August 2016

1 reference

3031

17 August 2016

1 reference

2953

17 August 2016

1 reference

2954

17 August 2016

1 reference

2955

English

http://purl.uniprot.org/uniprot/P04035

17 August 2016

Gene Atlas image

PBB GE HMGCR 202539 s at fs.png
732 × 530; 11 KB

0 references

exact match

1 reference

Identifiers.org

has part(s)

Sterol-sensing domain

1 reference

http://www.ebi.ac.uk/interpro/protein/P04035

Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site

1 reference

http://www.ebi.ac.uk/interpro/protein/P04035

Commons category

HMG-CoA reductase

0 references

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

Transporter Classification Database ID

English

2.A.6.6.5

2 references

Transporter Classification database

13 March 2020

Transporter Classification database